Search Keyword:


Search option:


IID00215
 UniprotQ53HL2
ProteinBorealin
GeneCDCA8
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
280
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 10-76 Hetero tetramer : IID00186Complex,IID00224Complex
 Evidence X-RAY 6yih B Reference
       Region 6yih B 10-16 disorder
       Region 6yih B 17-76 order
 Evidence X-RAY 6yif B Reference
       Region 6yif B 10-20 disorder
       Region 6yif B 21-76 order
Seq 10-109 Hetero hexamer : IID00186Complex,IID00224Complex
 Evidence X-RAY 6yie E Reference
       Region 6yie E 10-16 disorder
       Region 6yie E 17-76 order
       Region 6yie E 77-109 disorder
 Evidence X-RAY 6yie B Reference
       Region 6yie B 10-14 disorder
       Region 6yie B 15-76 order
       Region 6yie B 77-109 disorder
Seq 15-76 Hetero trimer : IID00186Complex,IID00224Complex
 Evidence X-RAY 2qfa B Reference
       Region 2qfa B 15-76 order
Seq 20-78 Hetero dimer : IID00186Complex
 Evidence X-RAY 2raw B Reference
       Region 2raw B 20-20 disorder
       Region 2raw B 21-76 order
       Region 2raw B 77-78 disorder
 Evidence X-RAY 2rax B Reference
       Region 2rax B 20-76 order
       Region 2rax B 77-78 disorder
 Evidence X-RAY 2rax F Reference
       Region 2rax F 20-76 order
       Region 2rax F 77-78 disorder
 Evidence X-RAY 2rax Y Reference
       Region 2rax Y 20-76 order
       Region 2rax Y 77-78 disorder
Seq 137-145 Hetero dimer : IID00379Complex
 Evidence X-RAY 7u5v C Reference
       Region 7u5v C 137-141 disorder
       Region 7u5v C 142-145 order
Seq 207-280 Homo dimer :
 Evidence NMR 2kdd B Reference
       Region 2kdd B 207-223 disorder
       Region 2kdd B 224-280 order
       Region 2kdd B 280-280 high_rmsd
 Evidence NMR 2kdd A Reference
       Region 2kdd A 207-223 disorder
       Region 2kdd A 224-280 order
       Region 2kdd A 280-280 high_rmsd
SeqProS predicted 142-145 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00379Complex
       Region 7u5v C 142-145 order
Seqphosphorylation
    106-106 Phosphothreonine
    94-94 Phosphothreonine; by TTK
    88-88 Phosphothreonine; by TTK
    165-165 Phosphoserine; by AURKB
    169-169 Phosphothreonine; by TTK
    189-189 Phosphothreonine
    204-204 Phosphothreonine
    219-219 Phosphoserine
    224-224 Phosphoserine
    230-230 Phosphothreonine; by TTK
    238-238 Phosphoserine
    244-244 Phosphoserine
    110-110 Phosphoserine
 
Prediction
NeProc
Disorder 1-17,83-115,144-214
Order 18-82,116-143,215-280
ProS 83-95,165-174,180-214
AlphaFold
Disorder 1-9,80-202,213-221,279-280
Order 10-79,203-212,222-278
SEG 125-133
Function
Function in SwissProt
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
Biological Process
See also
Diagram with PDB data
AURKB/INCENPHuman Aurora B Kinase in complex with INCENP and VX-680