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IID00342
 UniprotO60573
ProteinEukaryotic translation initiation factor 4E type 2
GeneEIF4E2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
245
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 45-234 Hetero dimer : IID00170Complex
 Evidence X-RAY 2jgc A Reference
       Region 2jgc A 45-46 disorder
       Region 2jgc A 47-71 order
       Region 2jgc A 72-79 disorder
       Region 2jgc A 80-219 order
       Region 2jgc A 220-227 disorder
       Region 2jgc A 228-234 order
 Evidence X-RAY 2jgb A Reference
       Region 2jgb A 45-224 order
       Region 2jgb A 225-227 disorder
       Region 2jgb A 228-234 order
Seq 52-234 Hetero tetramer : IID00170Complex
 Evidence X-RAY 5nvn C Reference
       Region 5nvn C 52-67 order
       Region 5nvn C 68-80 disorder
       Region 5nvn C 81-224 order
       Region 5nvn C 225-234 disorder
 Evidence X-RAY 5nvn A Reference
       Region 5nvn A 52-66 order
       Region 5nvn A 67-80 disorder
       Region 5nvn A 81-224 order
       Region 5nvn A 225-234 disorder
Seq 52-234 Hetero tetramer : Q6Y7W6
 Evidence X-RAY 5nvm C Reference
       Region 5nvm C 52-67 order
       Region 5nvm C 68-79 disorder
       Region 5nvm C 80-219 order
       Region 5nvm C 220-234 disorder
 Evidence X-RAY 5nvm A Reference
       Region 5nvm A 52-221 order
       Region 5nvm A 222-234 disorder
Seq 52-234 Hetero octamer : O75420
 Evidence X-RAY 5nvk G Reference
       Region 5nvk G 52-69 order
       Region 5nvk G 70-80 disorder
       Region 5nvk G 81-233 order
       Region 5nvk G 234-234 disorder
 Evidence X-RAY 5nvk E Reference
       Region 5nvk E 52-219 order
       Region 5nvk E 220-234 disorder
 Evidence X-RAY 5nvk C Reference
       Region 5nvk C 52-219 order
       Region 5nvk C 220-234 disorder
 Evidence X-RAY 5nvk A Reference
       Region 5nvk A 52-69 order
       Region 5nvk A 70-78 disorder
       Region 5nvk A 79-232 order
       Region 5nvk A 233-234 disorder
Seq 52-234 Hetero tetramer : Q6Y7W6
 Evidence X-RAY 5nvl C Reference
       Region 5nvl C 52-68 order
       Region 5nvl C 69-80 disorder
       Region 5nvl C 81-218 order
       Region 5nvl C 219-234 disorder
 Evidence X-RAY 5nvl A Reference
       Region 5nvl A 52-69 order
       Region 5nvl A 70-78 disorder
       Region 5nvl A 79-218 order
       Region 5nvl A 219-234 disorder
Seqphosphorylation
    13-13 Phosphoserine
Seqacetylation
    134-134 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-50,239-245
Order 51-238
ProS 1-10,239-245
AlphaFold
Disorder 1-44,223-245
Order 45-222
Pfam Hmmer
PF01652 18-237 2.6e-132
Function
Function in SwissProt
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap.