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IID00373
 UniprotP55055
ProteinOxysterols receptor LXR-beta
GeneNR1H2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
460
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 72-460 Hetero tetramer : IID00031Complex,IID00082Complex
 Evidence X-RAY 4nqa I Reference
       Region 4nqa I 72-74 disorder
       Region 4nqa I 75-458 order
       Region 4nqa I 459-460 disorder
 Evidence X-RAY 4nqa B Reference
       Region 4nqa B 72-73 disorder
       Region 4nqa B 74-191 order
       Region 4nqa B 192-207 disorder
       Region 4nqa B 208-457 order
       Region 4nqa B 458-460 disorder
Seq 208-460 Monomer :
 Evidence X-RAY 1upv A Reference
       Region 1upv A 208-217 disorder
       Region 1upv A 218-236 order
       Region 1upv A 237-247 disorder
       Region 1upv A 248-460 order
 Evidence X-RAY 1upw A Reference
       Region 1upw A 208-217 disorder
       Region 1upw A 218-236 order
       Region 1upw A 237-247 disorder
       Region 1upw A 248-460 order
Seq 210-460 Hetero trimer : IID00082Complex,IID00368Complex
 Evidence X-RAY 5i4v E Reference
       Region 5i4v E 210-216 disorder
       Region 5i4v E 217-253 order
       Region 5i4v E 254-259 disorder
       Region 5i4v E 260-458 order
       Region 5i4v E 459-460 disorder
Seq 210-460 Hetero dimer : IID00368Complex
 Evidence X-RAY 5hjp B Reference
       Region 5hjp B 216-252 order
       Region 5hjp B 253-254 disorder
       Region 5hjp B 255-460 order
 Evidence X-RAY 5hjp D Reference
       Region 5hjp D 216-217 disorder
       Region 5hjp D 218-252 order
       Region 5hjp D 253-260 disorder
       Region 5hjp D 261-460 order
 Evidence X-RAY 5kya A Reference
       Region 5kya A 210-216 disorder
       Region 5kya A 217-253 order
       Region 5kya A 254-259 disorder
       Region 5kya A 260-457 order
       Region 5kya A 458-460 disorder
 Evidence X-RAY 5kya E Reference
       Region 5kya E 210-216 disorder
       Region 5kya E 217-458 order
       Region 5kya E 459-460 disorder
 Evidence X-RAY 5kyj A Reference
       Region 5kyj A 210-216 disorder
       Region 5kyj A 217-458 order
       Region 5kyj A 459-460 disorder
 Evidence X-RAY 5kyj E Reference
       Region 5kyj E 210-216 disorder
       Region 5kyj E 217-253 order
       Region 5kyj E 254-259 disorder
       Region 5kyj E 260-457 order
       Region 5kyj E 458-460 disorder
Seq 210-460 Hetero trimer : IID00082Complex,IID00368Complex
 Evidence X-RAY 5i4v A Reference
       Region 5i4v A 210-216 disorder
       Region 5i4v A 217-460 order
Seq 212-460 Homo dimer :
 Evidence X-RAY 5jy3 A Reference
       Region 5jy3 A 213-217 disorder
       Region 5jy3 A 218-240 order
       Region 5jy3 A 241-245 disorder
       Region 5jy3 A 246-252 order
       Region 5jy3 A 253-259 disorder
       Region 5jy3 A 260-457 order
       Region 5jy3 A 458-460 disorder
 Evidence X-RAY 5jy3 B Reference
       Region 5jy3 B 213-217 disorder
       Region 5jy3 B 218-242 order
       Region 5jy3 B 243-245 disorder
       Region 5jy3 B 246-252 order
       Region 5jy3 B 253-259 disorder
       Region 5jy3 B 260-457 order
       Region 5jy3 B 458-460 disorder
 Evidence X-RAY 5jy3 C Reference
       Region 5jy3 C 213-217 disorder
       Region 5jy3 C 218-252 order
       Region 5jy3 C 253-256 disorder
       Region 5jy3 C 257-329 order
       Region 5jy3 C 330-331 disorder
       Region 5jy3 C 332-443 order
       Region 5jy3 C 444-446 disorder
       Region 5jy3 C 447-457 order
       Region 5jy3 C 458-460 disorder
 Evidence X-RAY 5jy3 D Reference
       Region 5jy3 D 213-217 disorder
       Region 5jy3 D 218-240 order
       Region 5jy3 D 241-246 disorder
       Region 5jy3 D 247-252 order
       Region 5jy3 D 253-259 disorder
       Region 5jy3 D 260-457 order
       Region 5jy3 D 458-460 disorder
 Evidence X-RAY 3kfc A Reference
       Region 3kfc A 212-218 disorder
       Region 3kfc A 219-254 order
       Region 3kfc A 255-260 disorder
       Region 3kfc A 261-457 order
       Region 3kfc A 458-460 disorder
 Evidence X-RAY 3kfc B Reference
       Region 3kfc B 212-217 disorder
       Region 3kfc B 218-252 order
       Region 3kfc B 253-260 disorder
       Region 3kfc B 261-457 order
       Region 3kfc B 458-460 disorder
 Evidence X-RAY 3kfc C Reference
       Region 3kfc C 212-218 disorder
       Region 3kfc C 219-241 order
       Region 3kfc C 242-266 disorder
       Region 3kfc C 267-338 order
       Region 3kfc C 339-347 disorder
       Region 3kfc C 348-438 order
       Region 3kfc C 439-460 disorder
 Evidence X-RAY 3kfc D Reference
       Region 3kfc D 212-218 disorder
       Region 3kfc D 219-254 order
       Region 3kfc D 255-260 disorder
       Region 3kfc D 261-457 order
       Region 3kfc D 458-460 disorder
 Evidence X-RAY 1pq6 A Reference
       Region 1pq6 A 212-218 disorder
       Region 1pq6 A 219-241 order
       Region 1pq6 A 242-245 disorder
       Region 1pq6 A 246-252 order
       Region 1pq6 A 253-257 disorder
       Region 1pq6 A 258-459 order
       Region 1pq6 A 460-460 disorder
 Evidence X-RAY 1pq6 B Reference
       Region 1pq6 B 212-218 disorder
       Region 1pq6 B 219-459 order
       Region 1pq6 B 460-460 disorder
 Evidence X-RAY 1pq6 C Reference
       Region 1pq6 C 212-218 disorder
       Region 1pq6 C 219-251 order
       Region 1pq6 C 252-262 disorder
       Region 1pq6 C 263-437 order
       Region 1pq6 C 438-460 disorder
 Evidence X-RAY 1pq6 D Reference
       Region 1pq6 D 212-218 disorder
       Region 1pq6 D 219-243 order
       Region 1pq6 D 244-246 disorder
       Region 1pq6 D 247-253 order
       Region 1pq6 D 254-261 disorder
       Region 1pq6 D 262-443 order
       Region 1pq6 D 444-446 disorder
       Region 1pq6 D 447-459 order
       Region 1pq6 D 460-460 disorder
 Evidence X-RAY 1pq9 A Reference
       Region 1pq9 A 212-218 disorder
       Region 1pq9 A 219-252 order
       Region 1pq9 A 253-259 disorder
       Region 1pq9 A 260-457 order
       Region 1pq9 A 458-460 disorder
 Evidence X-RAY 1pq9 B Reference
       Region 1pq9 B 212-217 disorder
       Region 1pq9 B 218-257 order
       Region 1pq9 B 258-259 disorder
       Region 1pq9 B 260-457 order
       Region 1pq9 B 458-460 disorder
 Evidence X-RAY 1pq9 C Reference
       Region 1pq9 C 212-218 disorder
       Region 1pq9 C 219-242 order
       Region 1pq9 C 243-246 disorder
       Region 1pq9 C 247-253 order
       Region 1pq9 C 254-257 disorder
       Region 1pq9 C 258-457 order
       Region 1pq9 C 458-460 disorder
 Evidence X-RAY 1pq9 D Reference
       Region 1pq9 D 212-218 disorder
       Region 1pq9 D 219-241 order
       Region 1pq9 D 242-247 disorder
       Region 1pq9 D 248-251 order
       Region 1pq9 D 252-258 disorder
       Region 1pq9 D 259-328 order
       Region 1pq9 D 329-331 disorder
       Region 1pq9 D 332-442 order
       Region 1pq9 D 443-446 disorder
       Region 1pq9 D 447-457 order
       Region 1pq9 D 458-460 disorder
 Evidence X-RAY 1pqc A Reference
       Region 1pqc A 212-218 disorder
       Region 1pqc A 219-252 order
       Region 1pqc A 253-259 disorder
       Region 1pqc A 260-457 order
       Region 1pqc A 458-460 disorder
 Evidence X-RAY 1pqc B Reference
       Region 1pqc B 212-217 disorder
       Region 1pqc B 218-257 order
       Region 1pqc B 258-259 disorder
       Region 1pqc B 260-457 order
       Region 1pqc B 458-460 disorder
 Evidence X-RAY 1pqc C Reference
       Region 1pqc C 212-218 disorder
       Region 1pqc C 219-242 order
       Region 1pqc C 243-246 disorder
       Region 1pqc C 247-253 order
       Region 1pqc C 254-257 disorder
       Region 1pqc C 258-457 order
       Region 1pqc C 458-460 disorder
 Evidence X-RAY 1pqc D Reference
       Region 1pqc D 212-218 disorder
       Region 1pqc D 219-241 order
       Region 1pqc D 242-247 disorder
       Region 1pqc D 248-251 order
       Region 1pqc D 252-258 disorder
       Region 1pqc D 259-328 order
       Region 1pqc D 329-331 disorder
       Region 1pqc D 332-442 order
       Region 1pqc D 443-446 disorder
       Region 1pqc D 447-457 order
       Region 1pqc D 458-460 disorder
 Evidence X-RAY 4rak A Reference
       Region 4rak A 213-216 disorder
       Region 4rak A 217-442 order
       Region 4rak A 443-446 disorder
       Region 4rak A 447-456 order
       Region 4rak A 457-460 disorder
 Evidence X-RAY 4rak B Reference
       Region 4rak B 213-217 disorder
       Region 4rak B 218-252 order
       Region 4rak B 253-260 disorder
       Region 4rak B 261-457 order
       Region 4rak B 458-460 disorder
Seq 212-460 Hetero dimer : IID00082Complex
 Evidence X-RAY 3l0e A Reference
       Region 3l0e A 212-217 disorder
       Region 3l0e A 218-460 order
Seq 213-460 Hetero dimer : IID00083Complex
 Evidence X-RAY 1p8d B Reference
       Region 1p8d B 213-216 disorder
       Region 1p8d B 217-255 order
       Region 1p8d B 256-258 disorder
       Region 1p8d B 259-458 order
       Region 1p8d B 459-460 disorder
 Evidence X-RAY 1p8d A Reference
       Region 1p8d A 213-216 disorder
       Region 1p8d A 217-253 order
       Region 1p8d A 254-257 disorder
       Region 1p8d A 258-460 order
Seq 218-460 Hetero tetramer : IID00083Complex
 Evidence X-RAY 4dk7 A Reference
       Region 4dk7 A 218-243 order
       Region 4dk7 A 244-246 disorder
       Region 4dk7 A 247-253 order
       Region 4dk7 A 254-258 disorder
       Region 4dk7 A 259-458 order
       Region 4dk7 A 459-460 disorder
 Evidence X-RAY 4dk7 C Reference
       Region 4dk7 C 218-240 order
       Region 4dk7 C 241-245 disorder
       Region 4dk7 C 246-253 order
       Region 4dk7 C 254-260 disorder
       Region 4dk7 C 261-458 order
       Region 4dk7 C 459-460 disorder
 Evidence X-RAY 4dk8 A Reference
       Region 4dk8 A 218-243 order
       Region 4dk8 A 244-246 disorder
       Region 4dk8 A 247-252 order
       Region 4dk8 A 253-257 disorder
       Region 4dk8 A 258-457 order
       Region 4dk8 A 458-460 disorder
 Evidence X-RAY 4dk8 C Reference
       Region 4dk8 C 218-240 order
       Region 4dk8 C 241-245 disorder
       Region 4dk8 C 246-253 order
       Region 4dk8 C 254-260 disorder
       Region 4dk8 C 261-458 order
       Region 4dk8 C 459-460 disorder
 
Prediction
NeProc
Disorder 1-83,167-262
Order 84-166,263-460
ProS 1-15,167-179,216-251
AlphaFold
Disorder 1-83,177-217,459-460
Order 84-176,218-458
Pfam Hmmer
PF00105 85-162 1.7e-33
PF00104 275-455 1.5e-55
SEG 2-28 ,32-51 ,65-80 ,117-129 ,138-150 ,173-218
Function
Function in SwissProt
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957).
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment