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IID00377
 UniprotP61964
ProteinWD repeat-containing protein 5
GeneWDR5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
334
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-334 Monomer :
 Evidence X-RAY 5eal A Reference
       Region 5eal A 24-30 disorder
       Region 5eal A 31-334 order
 Evidence X-RAY 5eal B Reference
       Region 5eal B 24-30 disorder
       Region 5eal B 31-334 order
 Evidence X-RAY 5eam A Reference
       Region 5eam A 24-30 disorder
       Region 5eam A 31-334 order
 Evidence X-RAY 5eam B Reference
       Region 5eam B 24-30 disorder
       Region 5eam B 31-334 order
 Evidence X-RAY 5eap A Reference
       Region 5eap A 24-211 order
       Region 5eap A 212-213 disorder
       Region 5eap A 214-334 order
 Evidence X-RAY 5ear A Reference
       Region 5ear A 24-30 disorder
       Region 5ear A 31-210 order
       Region 5ear A 211-213 disorder
       Region 5ear A 214-334 order
 Evidence X-RAY 5ear B Reference
       Region 5ear B 24-30 disorder
       Region 5ear B 31-211 order
       Region 5ear B 212-214 disorder
       Region 5ear B 215-334 order
 Evidence X-RAY 4gm3 A Reference
       Region 4gm3 A 22-30 disorder
       Region 4gm3 A 31-334 order
 Evidence X-RAY 4gm3 B Reference
       Region 4gm3 B 22-30 disorder
       Region 4gm3 B 31-334 order
 Evidence X-RAY 4gm3 C Reference
       Region 4gm3 C 22-30 disorder
       Region 4gm3 C 31-334 order
 Evidence X-RAY 4gm3 D Reference
       Region 4gm3 D 22-30 disorder
       Region 4gm3 D 31-334 order
 Evidence X-RAY 4gm3 E Reference
       Region 4gm3 E 22-30 disorder
       Region 4gm3 E 31-334 order
 Evidence X-RAY 4gm3 F Reference
       Region 4gm3 F 22-30 disorder
       Region 4gm3 F 31-334 order
 Evidence X-RAY 4gm3 G Reference
       Region 4gm3 G 22-30 disorder
       Region 4gm3 G 31-334 order
 Evidence X-RAY 4gm3 H Reference
       Region 4gm3 H 22-30 disorder
       Region 4gm3 H 31-334 order
 Evidence X-RAY 4gm8 A Reference
       Region 4gm8 A 22-30 disorder
       Region 4gm8 A 31-210 order
       Region 4gm8 A 211-212 disorder
       Region 4gm8 A 213-334 order
 Evidence X-RAY 4gm8 B Reference
       Region 4gm8 B 22-32 disorder
       Region 4gm8 B 33-210 order
       Region 4gm8 B 211-212 disorder
       Region 4gm8 B 213-334 order
 Evidence X-RAY 4gm8 C Reference
       Region 4gm8 C 22-30 disorder
       Region 4gm8 C 31-210 order
       Region 4gm8 C 211-212 disorder
       Region 4gm8 C 213-334 order
 Evidence X-RAY 4gm8 D Reference
       Region 4gm8 D 22-30 disorder
       Region 4gm8 D 31-210 order
       Region 4gm8 D 211-214 disorder
       Region 4gm8 D 215-334 order
 Evidence X-RAY 4gm9 A Reference
       Region 4gm9 A 22-23 disorder
       Region 4gm9 A 24-210 order
       Region 4gm9 A 211-212 disorder
       Region 4gm9 A 213-334 order
 Evidence X-RAY 4gm9 B Reference
       Region 4gm9 B 22-24 disorder
       Region 4gm9 B 25-334 order
 Evidence X-RAY 4gmb A Reference
       Region 4gmb A 22-27 disorder
       Region 4gmb A 28-334 order
 Evidence X-RAY 2gnq A Reference
       Region 2gnq A 1-10 disorder
       Region 2gnq A 11-18 order
       Region 2gnq A 19-26 disorder
       Region 2gnq A 27-334 order
 Evidence X-RAY 2h14 A Reference
       Region 2h14 A 22-31 disorder
       Region 2h14 A 32-334 order
 Evidence X-RAY 2h68 A Reference
       Region 2h68 A 23-30 disorder
       Region 2h68 A 31-334 order
 Evidence X-RAY 2h68 B Reference
       Region 2h68 B 23-28 disorder
       Region 2h68 B 29-334 order
 Evidence X-RAY 2h9l A Reference
       Region 2h9l A 24-334 order
 Evidence X-RAY 4ia9 A Reference
       Region 4ia9 A 24-29 disorder
       Region 4ia9 A 30-334 order
 Evidence X-RAY 5m23 A Reference
       Region 5m23 A 22-32 disorder
       Region 5m23 A 33-332 order
       Region 5m23 A 333-334 disorder
 Evidence X-RAY 5m25 A Reference
       Region 5m25 A 22-32 disorder
       Region 5m25 A 33-332 order
       Region 5m25 A 333-334 disorder
 Evidence X-RAY 3mxx A Reference
       Region 3mxx A 31-334 order
 Evidence X-RAY 3n0d A Reference
       Region 3n0d A 31-334 order
 Evidence X-RAY 3n0e A Reference
       Region 3n0e A 31-334 order
 Evidence X-RAY 4ql1 A Reference
       Region 4ql1 A 24-30 disorder
       Region 4ql1 A 31-334 order
 Evidence X-RAY 4ql1 B Reference
       Region 4ql1 B 24-30 disorder
       Region 4ql1 B 31-210 order
       Region 4ql1 B 211-212 disorder
       Region 4ql1 B 213-334 order
 Evidence X-RAY 3smr A Reference
       Region 3smr A 24-30 disorder
       Region 3smr A 31-210 order
       Region 3smr A 211-212 disorder
       Region 3smr A 213-334 order
 Evidence X-RAY 3smr B Reference
       Region 3smr B 24-30 disorder
       Region 3smr B 31-211 order
       Region 3smr B 212-212 disorder
       Region 3smr B 213-334 order
 Evidence X-RAY 3smr C Reference
       Region 3smr C 24-30 disorder
       Region 3smr C 31-210 order
       Region 3smr C 211-211 disorder
       Region 3smr C 212-334 order
 Evidence X-RAY 3smr D Reference
       Region 3smr D 24-30 disorder
       Region 3smr D 31-210 order
       Region 3smr D 211-211 disorder
       Region 3smr D 212-334 order
 Evidence X-RAY 5sxm A Reference
       Region 5sxm A 23-30 disorder
       Region 5sxm A 31-334 order
 Evidence X-RAY 5sxm B Reference
       Region 5sxm B 23-31 disorder
       Region 5sxm B 32-334 order
 Evidence X-RAY 3ur4 A Reference
       Region 3ur4 A 24-30 disorder
       Region 3ur4 A 31-211 order
       Region 3ur4 A 212-212 disorder
       Region 3ur4 A 213-334 order
 Evidence X-RAY 3ur4 B Reference
       Region 3ur4 B 24-30 disorder
       Region 3ur4 B 31-210 order
       Region 3ur4 B 211-213 disorder
       Region 3ur4 B 214-334 order
 Evidence X-RAY 5vfc A Reference
       Region 5vfc A 24-30 disorder
       Region 5vfc A 31-334 order
Seq 20-334 Hetero dimer : IID00062Complex
 Evidence X-RAY 4a7j A Reference
       Region 4a7j A 21-31 disorder
       Region 4a7j A 32-334 order
 Evidence X-RAY 2co0 A Reference
       Region 2co0 A 20-30 disorder
       Region 2co0 A 31-334 order
 Evidence X-RAY 2co0 C Reference
       Region 2co0 C 20-30 disorder
       Region 2co0 C 31-334 order
Seq 20-334 Hetero dimer : IID50143Complex
 Evidence X-RAY 2cnx A Reference
       Region 2cnx A 20-28 disorder
       Region 2cnx A 29-334 order
Seq 21-334 Hetero dimer :
 Evidence X-RAY 3psl B Reference
       Region 3psl B 21-31 disorder
       Region 3psl B 32-209 order
       Region 3psl B 210-214 disorder
       Region 3psl B 215-334 order
Seq 21-334 Hetero dimer : IID00400Complex
 Evidence X-RAY 4erz A Reference
       Region 4erz A 23-30 disorder
       Region 4erz A 31-334 order
 Evidence X-RAY 4erz B Reference
       Region 4erz B 23-30 disorder
       Region 4erz B 31-334 order
 Evidence X-RAY 4erz C Reference
       Region 4erz C 23-30 disorder
       Region 4erz C 31-334 order
 Evidence X-RAY 3uvm A Reference
       Region 3uvm A 21-30 disorder
       Region 3uvm A 31-334 order
Seq 21-334 Hetero dimer : IID00389Complex
 Evidence X-RAY 4ery A Reference
       Region 4ery A 23-30 disorder
       Region 4ery A 31-334 order
 Evidence X-RAY 3uvl A Reference
       Region 3uvl A 21-30 disorder
       Region 3uvl A 31-210 order
       Region 3uvl A 211-211 disorder
       Region 3uvl A 212-334 order
Seq 21-334 Hetero dimer : IID00358Complex
 Evidence X-RAY 4ewr A Reference
       Region 4ewr A 23-30 disorder
       Region 4ewr A 31-334 order
 Evidence X-RAY 3uvn A Reference
       Region 3uvn A 21-30 disorder
       Region 3uvn A 31-334 order
 Evidence X-RAY 3uvn C Reference
       Region 3uvn C 21-30 disorder
       Region 3uvn C 31-334 order
Seq 21-334 Hetero dimer :
 Evidence X-RAY 3psl A Reference
       Region 3psl A 21-31 disorder
       Region 3psl A 32-209 order
       Region 3psl A 210-214 disorder
       Region 3psl A 215-334 order
Seq 21-334 Hetero dimer : IID00402Complex
 Evidence X-RAY 4es0 A Reference
       Region 4es0 A 23-30 disorder
       Region 4es0 A 31-334 order
 Evidence X-RAY 3uvo A Reference
       Region 3uvo A 21-30 disorder
       Region 3uvo A 31-210 order
       Region 3uvo A 211-214 disorder
       Region 3uvo A 215-334 order
Seq 21-334 Hetero dimer : IID00356Complex
 Evidence X-RAY 4erq A Reference
       Region 4erq A 23-30 disorder
       Region 4erq A 31-334 order
 Evidence X-RAY 4erq B Reference
       Region 4erq B 23-30 disorder
       Region 4erq B 31-334 order
 Evidence X-RAY 4erq C Reference
       Region 4erq C 23-30 disorder
       Region 4erq C 31-334 order
 Evidence X-RAY 3uvk A Reference
       Region 3uvk A 21-30 disorder
       Region 3uvk A 31-209 order
       Region 3uvk A 210-212 disorder
       Region 3uvk A 213-242 order
       Region 3uvk A 243-244 disorder
       Region 3uvk A 245-334 order
Seq 22-334 Hetero dimer : IID00012Complex
 Evidence X-RAY 4y7r A Reference
       Region 4y7r A 22-30 disorder
       Region 4y7r A 31-334 order
Seq 22-334 Hetero dimer :
 Evidence X-RAY 2h13 A Reference
       Region 2h13 A 22-31 disorder
       Region 2h13 A 32-334 order
Seq 22-334 Hetero trimer : IID00379Complex,IID00387Complex
 Evidence X-RAY 3p4f A Reference
       Region 3p4f A 22-30 disorder
       Region 3p4f A 31-334 order
Seq 23-334 Hetero dimer :
 Evidence X-RAY 2h6k B Reference
       Region 2h6k B 23-28 disorder
       Region 2h6k B 29-334 order
Seq 23-334 Hetero dimer :
 Evidence X-RAY 2h6n A Reference
       Region 2h6n A 23-30 disorder
       Region 2h6n A 31-334 order
Seq 23-334 Hetero dimer :
 Evidence X-RAY 2h6q B Reference
       Region 2h6q B 23-30 disorder
       Region 2h6q B 31-334 order
Seq 23-334 Hetero dimer :
 Evidence X-RAY 2h6k A Reference
       Region 2h6k A 23-29 disorder
       Region 2h6k A 30-334 order
Seq 23-334 Hetero dimer : IID00379Complex
 Evidence X-RAY 3eg6 A Reference
       Region 3eg6 A 23-30 disorder
       Region 3eg6 A 31-334 order
 Evidence X-RAY 3emh A Reference
       Region 3emh A 25-32 disorder
       Region 3emh A 33-332 order
       Region 3emh A 333-334 disorder
Seq 23-334 Hetero dimer :
 Evidence X-RAY 2h6n B Reference
       Region 2h6n B 23-29 disorder
       Region 2h6n B 30-334 order
Seq 23-334 Hetero trimer : IID00879Complex,IID00901Complex
 Evidence X-RAY 4cy2 A Reference
       Region 4cy2 A 23-30 disorder
       Region 4cy2 A 31-334 order
Seq 23-334 Hetero dimer :
 Evidence X-RAY 2h6q A Reference
       Region 2h6q A 23-30 disorder
       Region 2h6q A 31-334 order
Seq 23-334 Hetero dimer : IID00379Complex
 Evidence X-RAY 4esg A Reference
       Region 4esg A 23-30 disorder
       Region 4esg A 31-334 order
 Evidence X-RAY 4esg B Reference
       Region 4esg B 23-30 disorder
       Region 4esg B 31-334 order
Seq 23-334 Hetero dimer : IID00901Complex
 Evidence X-RAY 4cy1 A Reference
       Region 4cy1 A 23-30 disorder
       Region 4cy1 A 31-212 order
       Region 4cy1 A 213-213 disorder
       Region 4cy1 A 214-334 order
 Evidence X-RAY 4cy1 B Reference
       Region 4cy1 B 23-31 disorder
       Region 4cy1 B 32-211 order
       Region 4cy1 B 212-213 disorder
       Region 4cy1 B 214-334 order
Seq 24-334 Hetero dimer :
 Evidence X-RAY 2o9k C Reference
       Region 2o9k C 24-30 disorder
       Region 2o9k C 31-211 order
       Region 2o9k C 212-212 disorder
       Region 2o9k C 213-334 order
Seq 24-334 Hetero dimer : Q6P823
 Evidence X-RAY 2h9m A Reference
       Region 2h9m A 24-30 disorder
       Region 2h9m A 31-334 order
 Evidence X-RAY 2h9m C Reference
       Region 2h9m C 24-30 disorder
       Region 2h9m C 31-334 order
 Evidence X-RAY 2h9n A Reference
       Region 2h9n A 24-30 disorder
       Region 2h9n A 31-334 order
 Evidence X-RAY 2h9n C Reference
       Region 2h9n C 24-30 disorder
       Region 2h9n C 31-334 order
 Evidence X-RAY 2h9p A Reference
       Region 2h9p A 24-30 disorder
       Region 2h9p A 31-334 order
Seq 24-334 Hetero dimer :
 Evidence X-RAY 2o9k A Reference
       Region 2o9k A 24-30 disorder
       Region 2o9k A 31-334 order
Seq 24-334 Hetero dimer : P03495
 Evidence X-RAY 4o45 A Reference
       Region 4o45 A 24-29 disorder
       Region 4o45 A 30-334 order
Seq 27-334 Hetero dimer :
 Evidence X-RAY 2g99 A Reference
       Region 2g99 A 27-29 disorder
       Region 2g99 A 30-333 order
       Region 2g99 A 334-334 disorder
Seq 27-334 Hetero dimer :
 Evidence X-RAY 2g99 B Reference
       Region 2g99 B 27-29 disorder
       Region 2g99 B 30-333 order
       Region 2g99 B 334-334 disorder
Seq 29-334 Hetero dimer :
 Evidence X-RAY 2g9a A Reference
       Region 2g9a A 29-333 order
       Region 2g9a A 334-334 disorder
Seqacetylation
    112-112 N6-acetyllysine
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-23
Order 24-334
ProS 23-23
AlphaFold
Disorder 1-28,30-30
Order 29-29,31-334
Pfam Hmmer
PF00400 35-73 9.5e-12
PF00400 77-115 1.9e-11
PF00400 119-157 4.6e-13
PF00400 161-199 2.6e-12
PF00400 203-242 9.8e-07
PF00400 246-287 2e-07
SEG 2-15
Function
Function in SwissProt
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.
Biological Process
See also
Diagram with PDB data
MYC/WDR5Crystal structure of WDR5 in complex with MYC MbIIIb peptide