20250201 20180803 20180328 20250201 IID00102 Beta-catenin-interacting protein 1 Inhibitor of beta-catenin and Tcf-4 Homo sapiens 81 Q9NSA3 Q5T4V2 Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. Cytoplasm. SL-0086 unkown Nucleus. SL-0191 unkown Phosphoserine 59 59 CTNNBIP1 Beta-catenin-interacting protein MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNSQLSQLPPHSIDQGAEDVVMAFSRSETEDRRQ 1 1lujB 1 4 disorder 1 2 1lujB 5 75 order 1 3 1t08B 8 53 order 2 4 1m1eB 1 8 disorder 3 5 1m1eB 9 54 order 3 6 1m1eB 55 59 disorder 3 7 1m1eB 60 78 order 3 8 1m1eB 79 81 disorder 3 9 1lujB 76 81 disorder 1 1 1luj X-RAY 293K 8 12408824 T.A.GRAHAM,W.K.CLEMENTS,D.KIMELMAN,W.XU THE CRYSTAL STRUCTURE OF THE BETA-CATENIN/ICAT COMPLEX REVEALS THE INHIBITORY MECHANISM OF ICAT. 2002 MOL.CELL 10 563 x-ray 1luj B 1 75 94 1 1 4 1 1luj_1 3802 Hetero dimer 1lujA P35222 IID00039 1lujB Q9NSA3 IID00102 1lujB-1lujA 2 1t08 X-RAY 297K 6.5 15327768 N.-C.HA,T.TONOZUKA,J.L.STAMOS,H.J.CHOI,W.I.WEIS MECHANISM OF PHOSPHORYLATION-DEPENDENT BINDING OF APC TO BETA-CATENIN AND ITS ROLE IN BETA-CATENIN DEGRADATION 2004 MOL.CELL 15 511 x-ray 1t08 B 8 53 100 0 1 1t08_1 4333 Hetero trimer 1t08C P25054 IID00035 1t08A P35222 IID00039 1t08B Q9NSA3 IID00102 1t08A-1t08C 1t08B-1t08A 3 1m1e X-RAY 298K 6.5 12408825 D.L.DANIELS,W.I.WEIS ICAT INHIBITS BETA-CATENIN BINDING TO TCF/LEF-FAMILY TRANSCRIPTION FACTORS AND THE GENERAL COACTIVATOR P300 USING INDEPENDENT STRUCTURAL MODULES. 2002 MOL.CELL 10 573 x-ray 1m1e B 1 81 100 3 1 8 55 59 79 81 1 1m1e_1 3830 Hetero dimer 1m1eA Q02248 IID50011 1m1eB Q9NSA3 IID00102 1m1eB-1m1eA ProS 1 possible 7 60 78 Beta-catenin binding domain (CBD) ProS 2 possible 2 60 75 Beta-catenin binding domain (CBD)
Q9NSA3-1 CTNNBIP1/Ctnnb1 Beta-catenin armadillo repeat domain bound to ICAT
9-57,70-72 1-8,58-69,73-81 5-73 1-4,74-81 1-4,74-78