20250201 20180803 20180328 20250201 IID00736 Coiled-coil domain-containing protein 8 Homo sapiens 538 Q9H0W5 Q8TB26 Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695). Nucleus membrane. SL-0182 unkown Lysosome membrane. SL-0157 unkown Cytoplasm, Cytoskeleton. SL-0090 unkown PxLPxI/L motif; mediates interaction with ANKRA2 500 506 Phosphoserine 142 142 Phosphoserine 146 146 Phosphoserine 261 261 CCDC8 Coiled-coil domain-containing pr MLQIGEDVDYLLIPREVRLAGGVWRVISKPATKEAEFRERLTQFLEEEGRTLEDVARIMEKSTPHPPQPPKKPKEPRVRRRVQQMVTPPPRLVVGTYDSSNASDSEFSDFETSRDKSRQGPRRGKKVRKMPVSYLGSKFLGSDLESEDDEELVEAFLRRQEKQPSAPPARRRVNLPVPMFEDNLGPQLSKADRWREYVSQVSWGKLKRRVKGWAPRAGPGVGEARLASTAVESAGVSSAPEGTSPGDRLGNAGDVCVPQASPRRWRPKINWASFRRRRKEQTAPTGQGADIEADQGGEAADSQREEAIADQREGAAGNQRAGAPADQGAEAADNQREEAADNQRAGAPAEEGAEAADNQREEAADNQRAEAPADQRSQGTDNHREEAADNQRAEAPADQGSEVTDNQREEAVHDQRERAPAVQGADNQRAQARAGQRAEAAHNQRAGAPGIQEAEVSAAQGTTGTAPGARARKQVKTVRFQTPGRFSWFCKRRRAFWHTPRLPTLPKRVPRAGEARNLRVLRAEARAEAEQGEQEDQL 1 4lg6B 494 497 disorder 1 2 4lg6B 498 510 order 1 1 4lg6 X-RAY 291K 7.5 25752541 J.NIE,C.XU,J.JIN,J.A.AKA,W.TEMPEL,V.NGUYEN,L.YOU,R.WEIST,J.MIN,T.PAWSON,X.J.YANG 2015 STRUCTURE 23 700 x-ray 4lg6 B 494 510 100 1 494 497 1 4lg6_1 3751 Hetero dimer 4lg6A Q9H9E1 4lg6B Q9H0W5 IID00736 4lg6B-4lg6A ProS 1 predicted 2 498 510 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5).

Q9H0W5-1 CCDC8/ANKRA2

17-17,22-22,24-26,36-51,53-55,57-58,154-154,190-190,192-193,195-196 1-16,18-21,23-23,27-35,52-52,56-56,59-153,155-189,191-191,194-194,197-538 1-62,74-79 67-73,80-538 89-99,128-159,171-179,193-197,207-212,245-255,263-274,412-419,480-500,506-525,535-538 66-84,142-152,321-333,345-356,428-441,458-471,514-538