A MINIMAL NUCLEAR LOCALIZATION SIGNAL (NLS) IN HUMAN PHOSPHOLIPID SCRAMBLASE 4 THAT BINDS ONLY THE MINOR NLS-BINDING SITE OF IMPORTIN {ALPHA}1.

20250201 IID00904 Phospholipid scramblase 4 Ca(2+)-dependent phospholipid scramblase 4 Cell growth-inhibiting gene 43 protein TRA1 Homo sapiens 329 Q9NRQ2 A8K2E9 Q2TTR3 Q658L3 Q6ZR73 Q7Z505 May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Cytoplasm. SL-0086 unkown SH3-binding 1 18 25 PPxY motif 30 33 SH3-binding 2 41 49 SH3-binding 3 98 106 Phosphotyrosine; by ABL 83 83 Phosphotyrosine; by ABL 88 88 PLSCR4 Phospholipid scramblase 4 MSGVVPTAPEQPAGEMENQTKPPDPRPDAPPEYNSHFLPGPPGTAVPPPTGYPGGLPMGYYSPQQPSTFPLYQPVGGIHPVRYQPGKYPMPNQSVPITWMPGPTPMANCPPGLEYLVQLDNIHVLQHFEPLEMMTCFETNNRYDIKNNSDQMVYIVTEDTDDFTRNAYRTLRPFVLRVTDCMGREIMTMQRPFRCTCCCFCCPSARQELEVQCPPGVTIGFVAEHWNLCRAVYSIQNEKKENVMRVRGPCSTYGCGSDSVFEVKSLDGISNIGSIIRKWNGLLSAMADADHFDIHFPLDLDVKMKAMIFGACFLIDFMYFERSPPQRSR 1 3q5uB 271 272 disorder 1 2 3q5uB 273 280 order 1 3 3q5uB 281 283 disorder 1 1 3q5u X-RAY 293K 6 21690087 K.LOTT,A.BHARDWAJ,P.J.SIMS,G.CINGOLANI A MINIMAL NUCLEAR LOCALIZATION SIGNAL (NLS) IN HUMAN PHOSPHOLIPID SCRAMBLASE 4 THAT BINDS ONLY THE MINOR NLS-BINDING SITE OF IMPORTIN {ALPHA}1. 2011 J.BIOL.CHEM. 286 28160 x-ray 3q5u B 271 283 100 2 271 272 281 283 1 3q5u_1 4199 Hetero dimer 3q5uB Q9NRQ2 IID00904 3q5uA P52293 IID50009 3q5uA-3q5uB ProS 1 possible 2 273 280 Nuclear Localization Signal (NLS)

Q9NRQ2-1 PLSCR4/Kpna2 A minimal NLS from human scramblase 4 complexed with importin alpha

96-128,140-161,169-169,171-194,202-250,256-280,289-321 1-95,129-139,162-168,170-170,195-201,251-255,281-288,322-329 107-324 1-106,325-329 1-10,24-43,68-71,78-87 22-31,39-55,191-203