20250201 20180803 20180328 20250201 IID50004 Cyclic AMP-responsive element-binding protein 1 Rattus norvegicus 327 P15337 Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (By similarity). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (PubMed:30566056). 0 0 Phosphoserine; by CaMK1, CaMK2, CaMK4, PKB/AKT1 or PKB/AKT2, RPS6KA3, RPS6KA4, RPS6KA5 and SGK1 119 119 Phosphoserine; by CaMK2 128 128 Phosphoserine; by HIPK2 257 257 Creb1 Cyclic AMP-responsive element-bi MTMDSGADNQQSGDAAVTEAESQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD 5 1kdxB 105 132 order 1 6 1kdxB 87 106 disorder 1 7 1kdxB 132 146 disorder 1 8 87 146 disorder 2 1 1kdx NMR 9413984 I.RADHAKRISHNAN,G.C.PEREZ-ALVARADO,D.PARKER,H.J.DYSON,M.R.MONTMINY,P.E.WRIGHT SOLUTION STRUCTURE OF THE KIX DOMAIN OF CBP BOUND TO THE TRANSACTIVATION DOMAIN OF CREB: A MODEL FOR ACTIVATOR:COACTIVATOR INTERACTIONS. 1997 CELL(CAMBRIDGE,MASS.) 91 741 nmr 1kdx B 105 132 96 0 1 1kdx 6066 Hetero dimer 1kdxB P15337 IID50004 1kdxA P45481 IID50008 1kdxA-1kdxB 2 NMR 9413984 I.RADHAKRISHNAN,G.C.PEREZ-ALVARADO,D.PARKER,H.J.DYSON,M.R.MONTMINY,P.E.WRIGHT SOLUTION STRUCTURE OF THE KIX DOMAIN OF CBP BOUND TO THE TRANSACTIVATION DOMAIN OF CREB: A MODEL FOR ACTIVATOR:COACTIVATOR INTERACTIONS. 1997 CELL(CAMBRIDGE,MASS.) 91 741 ProS 1 verified 5 107 131 8 87 146
P15337-1 Creb1/Crebbp KIX DOMAIN OF MOUSE CBP (CREB BINDING PROTEIN) IN COMPLEX WITH PHOSPHORYLATED KINASE INDUCIBLE DOMAIN (PKID) OF RAT CREB (CYCLIC AMP RESPONSE ELEMENT BINDING PROTEIN), NMR 17 STRUCTURES
104-129,159-172,174-175,177-180,215-215,220-220,231-232,234-239,264-325 1-103,130-158,173-173,176-176,181-214,216-219,221-230,233-233,240-263,326-327 277-327 1-276 65-69,78-91,120-138,164-177,205-209,218-222,227-232,270-276 93-108,138-145,148-160,278-292