STRUCTURAL BASIS OF ADHESION-MOLECULE RECOGNITION BY ERM PROTEINS REVEALED BY THE CRYSTAL STRUCTURE OF THE RADIXIN-ICAM-2 COMPLEX

20250201 20180803 20180328 20250201 IID50119 Intercellular adhesion molecule 2 Lymphocyte function-associated AG-1 counter-receptor Mus musculus 277 P35330 Q9D8Q4 ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. 0 0 0 0 Icam2 Intercellular adhesion molecule MSSFACWSLSLLILFYSPGSGEKAFEVYIWSEKQIVEATESWKINCSTNCAAPDMGGLETPTNKIMLEEHPQGKWKQFLVSNVSKDTVFFCHFTCSGKQHSESLNIRVYQPPAQVTLKLQPPRVFVGEDFTIECTVSPVQPLERLTLSLLRGRETLKNQTFGGAETVPQEATATFNSTALKKDGLNFSCQAELDLRPHGGYIIRSISEYQILEVYEPMQDNQMVIIIVVVSILLFLFVTSVLLCFIFGQHWHRRRTGTYGVLAAWRRLPRAFRARPV 1 1j19B 253 268 order 1 1 1j19 X-RAY 277K 6 12554651 K.HAMADA,T.SHIMIZU,S.YONEMURA,S.TSUKITA,S.TSUKITA,T.HAKOSHIMA STRUCTURAL BASIS OF ADHESION-MOLECULE RECOGNITION BY ERM PROTEINS REVEALED BY THE CRYSTAL STRUCTURE OF THE RADIXIN-ICAM-2 COMPLEX 2003 EMBO J. 22 502 x-ray 1j19 B 253 268 100 0 1 1j19_1 3530 Hetero dimer 1j19B P35330 IID50119 1j19A P26043 IID50114 1j19A-1j19B

P35330-1 Icam2/Rdx Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide

24-163,166-181,185-217,221-254 1-23,164-165,182-184,218-220,255-277 20-203,209-265 1-19,266-277 1-19,266-277 224-243