20250201 20180803 20180328 20250201 IID50261 Transcription factor SOX-2 Mus musculus 319 P48432 Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. 0 0 Phosphoserine 253 253 Sox2 Transcription factor SOX-2 MYNMMETELKPPGPQQASGGGGGGGNATAAATGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGGGLNQRMDSYAHMNGWSNGSYSMMQEQLGYPQHPGLNAHGAAQMQPMHRYVVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMAQHYQSGPVPGTAKYGTLPLSHM 1 1gt0D 41 119 order 1 2 1gt0D 120 120 disorder 1 1 1gt0 X-RAY 7 12923055 A.REMENYI,K.LINS,L.J.NISSEN,R.REINBOLD,H.R.SCHOLER,M.WILMANNS CRYSTAL STRUCTURE OF A POU/HMG/DNA TERNARY COMPLEX SUGGESTS DIFFERENTIAL ASSEMBLY OF OCT4 AND SOX2 ON TWO ENHANCERS 2003 GENES DEV. 17 2048 x-ray 1gt0 D 41 120 100 1 120 120 1 1gt0_1 3354 Hetero dimer 1gt0D P48432 IID50261 1gt0C P14859 IID00144 1gt0C-1gt0D ProS 1 possible 1 105 115 Same region of human homolog (P48431, 950dentity) is disordered in the free state.
P48432-1 Sox2/POU2F1/DNA Crystal structure of a POU/HMG/DNA ternary complex
41-121,273-275,277-278 1-40,122-272,276-276,279-319 51-113 1-50,114-319 1-11,40-50,150-167,267-282,312-319 19-35,137-156,248-263