1.0.0 G0SDW4-1 1 1 1 ctPRC2 in an autoinhibited conformation:PDB: 5BJS (Apo ctPRC2), 5TQR(ctPRC2 bound to S-adenosylmethionine) FALSE 5bjs 5tqr CTHT_0053230 1 G0SDW4 IID50297 FALSE 5bjsB 5tqrB CTHT_0029920 1 G0S8H7 FALSE CTHT_0006210 1 G0RYC6 FALSE 2 1 1 FALSE 5kji CTHT_0053230 1 G0SDW4 IID50297 basal state, SRM is disordered. FALSE 5kjiB CTHT_0029920 1 G0S8H7 FALSE CTHT_0006210 1 G0RYC6 FALSE 3 1 1 FALSE CTHT_0053230 1 G0SDW4 IID50297 FALSE CTHT_0029920 1 G0S8H7 FALSE CTHT_0006210 1 G0RYC6 FALSE 2 1 FALSE CTHT_0002980(me3) 1 G0RZH5 2 P68431 IID00062 chromatin-associated; tri-methylated at Lys-28 (H3K27me3) FALSE me3 1 28 28 4 1 1 PDB: 5KJH, 5M5G contains ctEZH2, ctEED, ctSUZ12 (Vefs) and human H3K27me3 peptide. FALSE 5kjh 5m5g CTHT_0053230 1 G0SDW4 IID50297 stimulated state FALSE 5kjhB 5m5gB CTHT_0029920 1 G0S8H7 FALSE CTHT_0006210 1 G0RYC6 FALSE CTHT_0002980(me3) 1 G0RZH5 2 P68431 IID00062 FALSE me3 1 28 28 5 1 1 FALSE CTHT_0053230 1 G0SDW4 IID50297 FALSE CTHT_0029920 1 G0S8H7 FALSE CTHT_0006210 1 G0RYC6 FALSE CTHT_0002980(me3) 1 G0RZH5 2 P68431 IID00062 FALSE me3 1 28 28 2 1 FALSE CTHT_0002980 1 G0RZH5 2 P68431 IID00062 chromatin-associated FALSE 6 1 1 PDB:5KKL contains ctEZH2, ctEED, ctSUZ12 (Vefs), human H3K27me3 peptide and human oncogenic H3K27M peptide, which binds to the EZH2-SET domain and inhibits its methyltransferase activity. FALSE 5kkl CTHT_0053230 1 G0SDW4 IID50297 facilitates gene repression by propagating H3K27 methylation. FALSE 5kklB CTHT_0029920 1 G0S8H7 FALSE CTHT_0006210 1 G0RYC6 FALSE CTHT_0002980(me3) 1 G0RZH5 2 P68431 IID00062 FALSE me3 1 28 28 CTHT_0002980 1 G0RZH5 2 P68431 IID00062 FALSE 7 1 1 FALSE CTHT_0053230 1 G0SDW4 IID50297 FALSE CTHT_0029920 1 G0S8H7 FALSE CTHT_0006210 1 G0RYC6 FALSE CTHT_0002980(me3) 1 G0RZH5 2 P68431 IID00062 FALSE me3 1 28 28 8 1 1 FALSE CTHT_0053230 1 G0SDW4 IID50297 FALSE CTHT_0029920 1 G0S8H7 FALSE CTHT_0006210 1 G0RYC6 FALSE CTHT_0002980(me3) 1 G0RZH5 2 P68431 IID00062 FALSE me3 1 28 28 CTHT_0002980(Me) 1 G0RZH5 2 P68431 IID00062 mono-, di-, or tri-methylated at Lys28 (H3K27me1/me2/me3) FALSE Methylation 1 28 28 1 1 FALSE 2 28008038 28008037 28607149 31123062 30951652 2 3 FALSE 4 3 5 FALSE 6 4 6 TRUE 7 8 1 1 result 2 1 2 operand 3 1 2 2 result 4 1 3 operand 5 1