<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<sbgn xmlns="http://sbgn.org/libsbgn/0.2">
  <map language="process description">
    <extension>
      <selfEntry uniprot="O15055" iid=""/>
      <renderInformation id="renderInformation" program-name="sbgnviz" program-version="6.0.2" background-color="#00000000">
        <listOfColorDefinitions>
          <colorDefinition id="color_transparence" value="#ffffffff"/>
          <colorDefinition id="color_stroke" value="#555555"/>
          <colorDefinition id="color_white" value="#ffffff"/>
          <colorDefinition id="color_red" value="#ff0000"/>
          <colorDefinition id="color_association" value="#707070ff"/>
          <colorDefinition id="color_dissociation" value="#ffffff"/>
          <colorDefinition id="color_location" value="#e7effaff"/>
          <colorDefinition id="color_phenotype" value="#e7effaff"/>
          <colorDefinition id="color_complex" value="#e7effaff"/>
        </listOfColorDefinitions>
        <listOfStyles>
          <style id="macromolecule" idList="0 Node1 Node2 Node3 Node4 Node7 Node8 Node5 Node11 Node13">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="prop_phenotype" idList="0 Node6 Node9 Node14 Node15">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_phenotype" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="edge" idList="0 Node2-Node6 Node7-Node9 Node1-Node10.1 Node2-Node10.1 Node10.2-Node3 Node11-Node14 Node13-Node15 Node3-Node16.1 Node4-Node16 Node16.2-Node5">
            <g stroke="color_stroke" stroke-width="1.25"/>
          </style>
          <style id="association" idList="0 Node10">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_association" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="state_variable" idList="0 Node12">
            <g stroke="color_stroke" stroke-width="1" fill="color_white" font-size="9" font-family="monospace" font-weight="normal" font-style="normal" font-color="#0f0f0f"/>
          </style>
          <style id="process" idList="0 Node16">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" background-image-opacity="1" background-opacity="1"/>
          </style>
        </listOfStyles>
      </renderInformation>
      <mapProperties>
        <compoundPadding>0</compoundPadding>
        <extraCompartmentPadding>14</extraCompartmentPadding>
        <extraComplexPadding>10</extraComplexPadding>
        <arrowScale>1.25</arrowScale>
        <showComplexName>true</showComplexName>
        <dynamicLabelSize>regular</dynamicLabelSize>
        <inferNestingOnLoad>false</inferNestingOnLoad>
        <fitLabelsToNodes>false</fitLabelsToNodes>
        <fitLabelsToInfoboxes>false</fitLabelsToInfoboxes>
        <recalculateLayoutOnComplexityManagement>true</recalculateLayoutOnComplexityManagement>
        <rearrangeOnComplexityManagement>true</rearrangeOnComplexityManagement>
        <animateOnDrawingChanges>true</animateOnDrawingChanges>
        <adjustNodeLabelFontSizeAutomatically>false</adjustNodeLabelFontSizeAutomatically>
        <enablePorts>true</enablePorts>
        <enableSIFTopologyGrouping>false</enableSIFTopologyGrouping>
        <allowCompoundNodeResize>true</allowCompoundNodeResize>
        <mapColorScheme>black_white</mapColorScheme>
        <mapColorSchemeStyle>solid</mapColorSchemeStyle>
        <mapName>Pathway #8</mapName>
        <highlightColor>#0B9BCD</highlightColor>
        <extraHighlightThickness>2</extraHighlightThickness>
      </mapProperties>
      <popperInfo>
        <glyph id="Node1">
          <entry uniprot="O15055"/>
        </glyph>
        <glyph id="Node2">
          <entry uniprot="P48730"/>
        </glyph>
        <glyph id="Node7">
          <entry uniprot="P48730"/>
        </glyph>
        <glyph id="Node8">
          <entry uniprot="O15055"/>
        </glyph>
        <glyph id="Node5">
          <pdb pdb_id="8d7m"/>
          <pdb pdb_id="8d7n"/>
          <pdb pdb_id="8d7o"/>
        </glyph>
        <glyph id="Node11">
          <entry uniprot="O15055"/>
          <pdb pdb_id="8d7mC"/>
          <pdb pdb_id="8d7nC"/>
          <pdb pdb_id="8d7oC"/>
        </glyph>
        <glyph id="Node13">
          <entry uniprot="P48730"/>
          <pdb pdb_id="8d7mA"/>
          <pdb pdb_id="8d7nA"/>
          <pdb pdb_id="8d7oA"/>
        </glyph>
        <arc id="Node1-Node10.1">
          <process process_no="1"/>
        </arc>
        <arc id="Node2-Node10.1">
          <process process_no="1"/>
        </arc>
        <arc id="Node10.2-Node3">
          <process process_no="1"/>
        </arc>
        <arc id="Node3-Node16.1">
          <process process_no="2"/>
        </arc>
        <arc id="Node4-Node16">
          <process process_no="2"/>
        </arc>
        <arc id="Node16.2-Node5">
          <process process_no="2"/>
        </arc>
      </popperInfo>
      <isEdited>true</isEdited>
    </extension>
    <glyph id="Node6" class="phenotype" obj_id="1">
      <label text="active"/>
      <bbox x="-50.528686717137106" y="139.097853614619" w="120" h="30"/>
    </glyph>
    <glyph id="Node9" class="phenotype" obj_id="3">
      <label text="phosphorylates the familial&#xA;advanced sleep phase&#xA;(FASP) region of PER2"/>
      <bbox x="134.86773168313857" y="120.68353131615882" w="243" h="30"/>
    </glyph>
    <glyph id="Node14" class="phenotype" obj_id="4">
      <label text="FASP phosphorylation leads to&#xA;feedback inhibition of CSNK1D&#xA;kinase activity (product inhibition)"/>
      <bbox x="455.88232996334364" y="-49.72207233188409" w="324" h="30"/>
    </glyph>
    <glyph id="Node15" class="phenotype" obj_id="4">
      <label text="inactive"/>
      <bbox x="400.5828723878828" y="134.6066987120248" w="120" h="30"/>
    </glyph>
    <glyph id="Node1" class="macromolecule" obj_id="1">
      <label text="PER2"/>
      <bbox x="-38.25" y="8.760416666666664" w="90" h="30"/>
    </glyph>
    <glyph id="Node2" class="macromolecule" obj_id="1">
      <label text="CSNK1D"/>
      <bbox x="-36.65169903346636" y="73.58747971487084" w="90" h="30"/>
    </glyph>
    <glyph id="Node3" class="complex" obj_id="2 3">
      <bbox x="170.93919112172557" y="0.062467249345814935" w="0" h="0"/>
      <glyph id="Node4" class="complex" obj_id="2 3">
        <bbox x="177.56419112172557" y="51.71416628281217" w="0" h="0"/>
        <glyph id="Node7" class="macromolecule" obj_id="2 3">
          <label text="CSNK1D"/>
          <bbox x="184.1891911217256" y="58.33916628281217" w="90" h="30"/>
        </glyph>
      </glyph>
      <glyph id="Node8" class="macromolecule" obj_id="2">
        <label text="PER2"/>
        <bbox x="183.45193387272323" y="6.687467249345815" w="90" h="30"/>
      </glyph>
    </glyph>
    <glyph id="Node10" class="association">
      <bbox x="104.66566602806324" y="44.28458344874096" w="15" h="15"/>
      <port id="Node10.1" x="113.79066602806324" y="53.40958344874096"/>
      <port id="Node10.2" x="113.79066602806324" y="53.40958344874096"/>
    </glyph>
    <glyph id="Node5" class="complex" obj_id="4">
      <bbox x="407.41099575726156" y="4.356442181744555" w="0" h="0"/>
      <glyph id="Node11" class="macromolecule" obj_id="4">
        <label text="PER2"/>
        <bbox x="414.03599575726156" y="10.981442181744555" w="90" h="30"/>
        <glyph id="Node12" class="state variable">
          <state value="Ps"/>
          <bbox x="0" y="0" w="12" h="12"/>
        </glyph>
      </glyph>
      <glyph id="Node13" class="macromolecule" obj_id="4">
        <label text="CSNK1D"/>
        <bbox x="416.455639242426" y="64.75535250498905" w="90" h="30"/>
      </glyph>
    </glyph>
    <glyph id="Node16" class="process">
      <bbox x="347.1880307681514" y="44.28458344874096" w="15" h="15"/>
      <port id="Node16.1" x="356.3130307681514" y="53.40958344874096"/>
      <port id="Node16.2" x="356.3130307681514" y="53.40958344874096"/>
    </glyph>
    <arc id="Node2-Node6" class="modulation" source="Node2" target="Node6">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node7-Node9" class="modulation" source="Node7" target="Node9">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node1-Node10.1" class="consumption" source="Node1" target="Node10.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node2-Node10.1" class="consumption" source="Node2" target="Node10.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node10.2-Node3" class="production" source="Node10.2" target="Node3">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node11-Node14" class="modulation" source="Node11" target="Node14">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node13-Node15" class="modulation" source="Node13" target="Node15">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node3-Node16.1" class="consumption" source="Node3" target="Node16.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node4-Node16" class="catalysis" source="Node4" target="Node16">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node16.2-Node5" class="production" source="Node16.2" target="Node5">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
  </map>
  <formatOutput>1</formatOutput>
</sbgn>
