1.0.0 O15055-1 1 1 1 FALSE PER2 1 O15055 FALSE 2 1 FALSE CSNK1D 1 P48730 active FALSE 2 1 1 FALSE PER2 1 O15055 FALSE CSNK1D 1 P48730 FALSE 3 1 1 FALSE CSNK1D 1 P48730 phosphorylates the familial advanced sleep phase (FASP) region of PER2 FALSE 4 1 1 FALSE 8d7m 8d7n 8d7o PER2(Ps) 1 O15055 FASP phosphorylation leads to feedback inhibition of CSNK1D kinase activity (product inhibition) FALSE 8d7mC 8d7nC 8d7oC Phosphorylations 1 662 662 2 665 665 3 668 668 4 671 671 5 674 674 CSNK1D 1 P48730 inactive FALSE 8d7mA 8d7nA 8d7oA 1 1 FALSE 2 37207626 33545069 2 2 TRUE 3 4