1.0.0 O15105-1 1 1 1 FALSE SMAD7 1 O15105 IID00135 elevated expression as a result of activated TGF-beta signaling FALSE 2 1 FALSE SMURF1|SMURF2|NEDD4L 1 Q9HAU4 IID00223 2 Q9HCE7 IID00328 3 Q96PU5 IID00114 FALSE 2 1 1 FALSE 2djy 2kxq 2ltz 2ltx 2lty SMAD7 1 O15105 IID00135 FALSE 2djyB 2kxqB 2ltzB 2ltxB 2ltyB SMURF1|SMURF2|NEDD4L 1 Q9HAU4 IID00223 2 Q9HCE7 IID00328 3 Q96PU5 IID00114 FALSE 2djyA 2kxqA 2ltzA 2ltxA 2ltyA 3 1 1 FALSE SMAD7 1 O15105 IID00135 FALSE SMURF1|SMURF2|NEDD4L 1 Q9HAU4 IID00223 2 Q9HCE7 IID00328 3 Q96PU5 IID00114 FALSE 2 1 FALSE TGFBR1(Ps) 1 P36897 IID00413 activated in a complex with the TGF-beta type II receptor, TGFBR2 FALSE Phosphorylations 1 4 1 1 FALSE SMAD7 1 O15105 IID00135 FALSE SMURF1|SMURF2|NEDD4L 1 Q9HAU4 IID00223 2 Q9HCE7 IID00328 3 Q96PU5 IID00114 FALSE TGFBR1(Ps) 1 P36897 IID00413 FALSE Phosphorylations 1 5 1 1 FALSE SMURF1|SMURF2|NEDD4L 1 Q9HAU4 IID00223 2 Q9HCE7 IID00328 3 Q96PU5 IID00114 FALSE 6 1 1 FALSE SMAD7 1 O15105 IID00135 FALSE SMURF1|SMURF2|NEDD4L 1 Q9HAU4 IID00223 2 Q9HCE7 IID00328 3 Q96PU5 IID00114 FALSE TGFBR1(Ps,Ub) 1 P36897 IID00413 FALSE Phosphorylations 1 Ubiquitination 1 7 1 1 FALSE SMAD7 1 O15105 IID00135 FALSE SMURF1|SMURF2|NEDD4L 1 Q9HAU4 IID00223 2 Q9HCE7 IID00328 3 Q96PU5 IID00114 FALSE 2 1 FALSE TGFBR1(Ps,Ub) 1 P36897 IID00413 undergoes proteasomal and/or lysosomal degradation; negative feedback loop by SMAD7 to down-regulate TGF-beta signaling FALSE Phosphorylations 1 Ubiquitination 1 1 1 FALSE 2 16641086 20937913 22921829 11163210 11278251 15496141 36714553 2 3 FALSE 4 3 4 TRUE 5 6 4 6 FALSE 7 1 1 result 2 1 2 operand 3 1