1.0.0 O43597-1 1 1 1 FALSE SPRY2(P) 1 O43597 IID00528 negative feedback regulator of multiple receptor tyrosine kinases including receptors for fibroblast growth factor (FGF) and epidermal growth factor (EGF); inhibitis MAPK/ERK pathway; FGF/EGF-induced phosphorylation at Y55 FALSE Phosphorylation 1 55 55 2 1 FALSE CBL 1 P22681 IID00300 FALSE 2 1 1 FALSE 3bum 5hky 5hkz 5hl0 SPRY2(P) 1 O43597 IID00528 inhibits Cbl-mediated ubiquitination/downregulation of EGFR by preventing formation of an EGFR-Cbl complex FALSE 3bumA 5hkyB 5hkzB 5hl0B Phosphorylation 1 55 55 CBL 1 P22681 IID00300 FALSE 3bumB 5hkyA 5hkzA 5hl0A 3 1 1 FALSE CBL 1 P22681 IID00300 FALSE 4 1 1 FALSE SPRY2(P,Ub) 1 O43597 IID00528 FALSE Phosphorylation 1 55 55 Ubiquitination 1 CBL 1 P22681 IID00300 FALSE 5 1 1 FALSE SPRY2(P,Ub) 1 O43597 IID00528 proteasomal degradation FALSE Phosphorylation 1 55 55 Ubiquitination 1 2 1 FALSE CBL 1 P22681 IID00300 FALSE 1 1 FALSE 2 18273061 12593795 2 2 TRUE 3 4 3 4 FALSE 5