<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<sbgn xmlns="http://sbgn.org/libsbgn/0.2">
  <map language="process description">
    <extension>
      <selfEntry uniprot="O95405" iid="IID00112"/>
      <renderInformation id="renderInformation" program-name="sbgnviz" program-version="6.0.2" background-color="#00000000">
        <listOfColorDefinitions>
          <colorDefinition id="color_transparence" value="#ffffffff"/>
          <colorDefinition id="color_stroke" value="#555555"/>
          <colorDefinition id="color_white" value="#ffffff"/>
          <colorDefinition id="color_red" value="#ff0000"/>
          <colorDefinition id="color_association" value="#707070ff"/>
          <colorDefinition id="color_dissociation" value="#ffffff"/>
          <colorDefinition id="color_location" value="#e7effaff"/>
          <colorDefinition id="color_phenotype" value="#e7effaff"/>
          <colorDefinition id="color_complex" value="#e7effaff"/>
        </listOfColorDefinitions>
        <listOfStyles>
          <style id="macromolecule" idList="0 Node1 Node2 Node3 Node4 Node5 Node12 Node13 Node14 Node6 Node16 Node17 Node19 Node7 Node8 Node9">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="prop_phenotype" idList="0 Node10 Node20 Node23">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_phenotype" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="edge" idList="0 Node3-Node10 Node3-Node11 Node1-Node15.1 Node2-Node15.1 Node3-Node15.1 Node15.2-Node4 Node17-Node20 Node4-Node21.1 Node5-Node21 Node21.2-Node6 Node8-Node23 Node6-Node24.1 Node24.2-Node7 Node24.2-Node8 Node24.2-Node9">
            <g stroke="color_stroke" stroke-width="1.25"/>
          </style>
          <style id="prop_complex" idList="0 Node11">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_complex" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="association" idList="0 Node15">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_association" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="state_variable" idList="0 Node18 Node22">
            <g stroke="color_stroke" stroke-width="1" fill="color_white" font-size="9" font-family="monospace" font-weight="normal" font-style="normal" font-color="#0f0f0f"/>
          </style>
          <style id="process" idList="0 Node21">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="dissociation" idList="0 Node24">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_dissociation" background-image-opacity="1" background-opacity="1"/>
          </style>
        </listOfStyles>
      </renderInformation>
      <mapProperties>
        <compoundPadding>0</compoundPadding>
        <extraCompartmentPadding>14</extraCompartmentPadding>
        <extraComplexPadding>10</extraComplexPadding>
        <arrowScale>1.25</arrowScale>
        <showComplexName>true</showComplexName>
        <dynamicLabelSize>regular</dynamicLabelSize>
        <inferNestingOnLoad>false</inferNestingOnLoad>
        <fitLabelsToNodes>false</fitLabelsToNodes>
        <fitLabelsToInfoboxes>false</fitLabelsToInfoboxes>
        <recalculateLayoutOnComplexityManagement>true</recalculateLayoutOnComplexityManagement>
        <rearrangeOnComplexityManagement>true</rearrangeOnComplexityManagement>
        <animateOnDrawingChanges>true</animateOnDrawingChanges>
        <adjustNodeLabelFontSizeAutomatically>false</adjustNodeLabelFontSizeAutomatically>
        <enablePorts>true</enablePorts>
        <enableSIFTopologyGrouping>false</enableSIFTopologyGrouping>
        <allowCompoundNodeResize>true</allowCompoundNodeResize>
        <mapColorScheme>black_white</mapColorScheme>
        <mapColorSchemeStyle>solid</mapColorSchemeStyle>
        <mapName>Pathway #8</mapName>
        <highlightColor>#0B9BCD</highlightColor>
        <extraHighlightThickness>2</extraHighlightThickness>
      </mapProperties>
      <popperInfo>
        <glyph id="Node1">
          <entry uniprot="O95405" iid="IID00112"/>
        </glyph>
        <glyph id="Node2">
          <entry uniprot="Q15796" iid="IID00127"/>
        </glyph>
        <glyph id="Node13">
          <entry uniprot="O95405" iid="IID00112"/>
          <pdb pdb_id="1devB"/>
          <complex gene="SMAD2" iid1="IID00112" iid2="IID00127" cluster="1026"/>
        </glyph>
        <glyph id="Node14">
          <entry uniprot="Q15796" iid="IID00127"/>
          <pdb pdb_id="1devA"/>
          <complex gene="ZFYVE9" iid1="IID00127" iid2="IID00112" cluster="1026"/>
        </glyph>
        <glyph id="Node16">
          <entry uniprot="O95405" iid="IID00112"/>
        </glyph>
        <glyph id="Node17">
          <entry uniprot="Q15796" iid="IID00127"/>
        </glyph>
        <glyph id="Node7">
          <entry uniprot="O95405" iid="IID00112"/>
        </glyph>
        <glyph id="Node8">
          <entry uniprot="Q15796" iid="IID00127"/>
        </glyph>
        <arc id="Node1-Node15.1">
          <process process_no="1"/>
        </arc>
        <arc id="Node2-Node15.1">
          <process process_no="1"/>
        </arc>
        <arc id="Node3-Node15.1">
          <process process_no="1"/>
        </arc>
        <arc id="Node15.2-Node4">
          <process process_no="1"/>
        </arc>
        <arc id="Node4-Node21.1">
          <process process_no="2"/>
        </arc>
        <arc id="Node5-Node21">
          <process process_no="2"/>
        </arc>
        <arc id="Node21.2-Node6">
          <process process_no="2"/>
        </arc>
        <arc id="Node6-Node24.1">
          <process process_no="3"/>
        </arc>
        <arc id="Node24.2-Node7">
          <process process_no="3"/>
        </arc>
        <arc id="Node24.2-Node8">
          <process process_no="3"/>
        </arc>
        <arc id="Node24.2-Node9">
          <process process_no="3"/>
        </arc>
      </popperInfo>
      <isEdited>true</isEdited>
    </extension>
    <glyph id="Node10" class="phenotype" obj_id="1">
      <label text="ligand-bound;&#xA;activated"/>
      <bbox x="190.42362430885834" y="-38.0687508623037" w="117" h="30"/>
    </glyph>
    <glyph id="Node11" class="phenotype" obj_id="1">
      <label text="e.g.&#xA;ACVR1B(ALK4)/ACVR2A"/>
      <bbox x="322.19764350931325" y="-38.760766334346634" w="171" h="30"/>
    </glyph>
    <glyph id="Node20" class="phenotype" obj_id="4">
      <label text="phosphorylated at the&#xA;C-terminal SXS sequence"/>
      <bbox x="707.4044782979342" y="230.0953644640123" w="207" h="30"/>
    </glyph>
    <glyph id="Node23" class="phenotype" obj_id="5">
      <label text="subsequently, forms a heterotrimeric complex with&#xA;Smad4; the complex translocates to the nucleus&#xA;and modulates the expression of target genes"/>
      <bbox x="1065.3353075766543" y="162.3504218083642" w="441" h="30"/>
    </glyph>
    <glyph id="Node1" class="macromolecule" obj_id="1">
      <label text="ZFYVE9"/>
      <bbox x="252.56891490376364" y="98.98707521681149" w="90" h="30"/>
    </glyph>
    <glyph id="Node2" class="macromolecule" obj_id="1">
      <label text="SMAD2"/>
      <bbox x="269.7557932708232" y="179.88452306846577" w="90" h="30"/>
    </glyph>
    <glyph id="Node3" class="macromolecule" obj_id="1">
      <label text="TGF-beta_receptor_complex"/>
      <bbox x="255.05068897413173" y="17.361147085711224" w="150" h="30"/>
    </glyph>
    <glyph id="Node4" class="complex" obj_id="2 3">
      <bbox x="436.02368992544234" y="52.93853605490071" w="0" h="0"/>
      <glyph id="Node5" class="complex" obj_id="2 3">
        <bbox x="442.64868992544234" y="59.56353605490072" w="0" h="0"/>
        <glyph id="Node12" class="macromolecule" obj_id="2 3">
          <label text="TGF-beta_receptor_complex"/>
          <bbox x="449.27368992544234" y="66.18853605490072" w="150" h="30"/>
        </glyph>
      </glyph>
      <glyph id="Node13" class="macromolecule" obj_id="2">
        <label text="ZFYVE9"/>
        <bbox x="480.7183559707066" y="108.694001242804" w="90" h="30"/>
      </glyph>
      <glyph id="Node14" class="macromolecule" obj_id="2">
        <label text="SMAD2"/>
        <bbox x="480.71671108548776" y="144.98903883039807" w="90" h="30"/>
      </glyph>
    </glyph>
    <glyph id="Node15" class="association">
      <bbox x="384.4595317044078" y="108.82705223582094" w="15" h="15"/>
      <port id="Node15.1" x="393.5845317044078" y="117.95205223582094"/>
      <port id="Node15.2" x="393.5845317044078" y="117.95205223582094"/>
    </glyph>
    <glyph id="Node6" class="complex" obj_id="4">
      <bbox x="729.9853374423648" y="29.882567145000877" w="0" h="0"/>
      <glyph id="Node16" class="macromolecule" obj_id="4">
        <label text="ZFYVE9"/>
        <bbox x="762.2369702945151" y="91.5187264757982" w="90" h="30"/>
      </glyph>
      <glyph id="Node17" class="macromolecule" obj_id="4">
        <label text="SMAD2"/>
        <bbox x="765.2289406575964" y="136.0981397477485" w="90" h="30"/>
        <glyph id="Node18" class="state variable">
          <state value="Ps"/>
          <bbox x="0" y="0" w="12" h="12"/>
        </glyph>
      </glyph>
      <glyph id="Node19" class="macromolecule" obj_id="4">
        <label text="TGF-beta_receptor_complex"/>
        <bbox x="736.6103374423648" y="36.50756714500086" w="150" h="30"/>
      </glyph>
    </glyph>
    <glyph id="Node21" class="process">
      <bbox x="663.0003238141461" y="102.90064439807043" w="15" h="15"/>
      <port id="Node21.1" x="672.1253238141461" y="112.02564439807043"/>
      <port id="Node21.2" x="672.1253238141461" y="112.02564439807043"/>
    </glyph>
    <glyph id="Node7" class="macromolecule" obj_id="5">
      <label text="ZFYVE9"/>
      <bbox x="985.8807194366527" y="33.42534794307264" w="90" h="30"/>
    </glyph>
    <glyph id="Node8" class="macromolecule" obj_id="5">
      <label text="SMAD2"/>
      <bbox x="948.9624420512839" y="155.33182537214805" w="90" h="30"/>
      <glyph id="Node22" class="state variable">
        <state value="Ps"/>
        <bbox x="0" y="0" w="12" h="12"/>
      </glyph>
    </glyph>
    <glyph id="Node9" class="macromolecule" obj_id="5">
      <label text="TGF-beta_receptor_complex"/>
      <bbox x="902.6832387767068" y="-8.187806498159777" w="150" h="30"/>
    </glyph>
    <glyph id="Node24" class="dissociation">
      <bbox x="920.5692614524347" y="97.63163055024485" w="15" h="15"/>
      <port id="Node24.1" x="929.6942614524347" y="106.75663055024485"/>
      <port id="Node24.2" x="929.6942614524347" y="106.75663055024485"/>
    </glyph>
    <arc id="Node3-Node10" class="modulation" source="Node3" target="Node10">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node3-Node11" class="modulation" source="Node3" target="Node11">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node1-Node15.1" class="consumption" source="Node1" target="Node15.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node2-Node15.1" class="consumption" source="Node2" target="Node15.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node3-Node15.1" class="consumption" source="Node3" target="Node15.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node15.2-Node4" class="production" source="Node15.2" target="Node4">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node17-Node20" class="modulation" source="Node17" target="Node20">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node4-Node21.1" class="consumption" source="Node4" target="Node21.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node5-Node21" class="catalysis" source="Node5" target="Node21">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node21.2-Node6" class="production" source="Node21.2" target="Node6">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node8-Node23" class="modulation" source="Node8" target="Node23">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node6-Node24.1" class="consumption" source="Node6" target="Node24.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node24.2-Node7" class="production" source="Node24.2" target="Node7">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node24.2-Node8" class="production" source="Node24.2" target="Node8">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node24.2-Node9" class="production" source="Node24.2" target="Node9">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
  </map>
  <formatOutput>1</formatOutput>
</sbgn>
