<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<sbgn xmlns="http://sbgn.org/libsbgn/0.2">
  <map language="process description">
    <extension>
      <selfEntry uniprot="P04271" iid="IID00410"/>
      <renderInformation id="renderInformation" program-name="sbgnviz" program-version="6.0.2" background-color="#00000000">
        <listOfColorDefinitions>
          <colorDefinition id="color_transparence" value="#ffffffff"/>
          <colorDefinition id="color_stroke" value="#555555"/>
          <colorDefinition id="color_white" value="#ffffff"/>
          <colorDefinition id="color_red" value="#ff0000"/>
          <colorDefinition id="color_association" value="#707070ff"/>
          <colorDefinition id="color_dissociation" value="#ffffff"/>
          <colorDefinition id="color_location" value="#e7effaff"/>
          <colorDefinition id="color_phenotype" value="#e7effaff"/>
          <colorDefinition id="color_complex" value="#e7effaff"/>
        </listOfColorDefinitions>
        <listOfStyles>
          <style id="macromolecule" idList="0 Node1 Node2 Node3 Node7 Node8 Node4 Node5 Node13 Node14 Node15">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="prop_phenotype" idList="0 Node6 Node9 Node10 Node12 Node16 Node17">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_phenotype" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="edge" idList="0 Node1-Node6 Node3-Node9 Node8-Node10 Node1-Node11.1 Node2-Node11.1 Node11.2-Node3 Node4-Node12 Node5-Node16 Node13-Node17 Node3-Node18.1 Node4-Node18.1 Node18.2-Node5">
            <g stroke="color_stroke" stroke-width="1.25"/>
          </style>
          <style id="association" idList="0 Node11 Node18">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_association" background-image-opacity="1" background-opacity="1"/>
          </style>
        </listOfStyles>
      </renderInformation>
      <mapProperties>
        <compoundPadding>0</compoundPadding>
        <extraCompartmentPadding>14</extraCompartmentPadding>
        <extraComplexPadding>10</extraComplexPadding>
        <arrowScale>1.25</arrowScale>
        <showComplexName>true</showComplexName>
        <dynamicLabelSize>regular</dynamicLabelSize>
        <inferNestingOnLoad>false</inferNestingOnLoad>
        <fitLabelsToNodes>false</fitLabelsToNodes>
        <fitLabelsToInfoboxes>false</fitLabelsToInfoboxes>
        <recalculateLayoutOnComplexityManagement>true</recalculateLayoutOnComplexityManagement>
        <rearrangeOnComplexityManagement>true</rearrangeOnComplexityManagement>
        <animateOnDrawingChanges>true</animateOnDrawingChanges>
        <adjustNodeLabelFontSizeAutomatically>false</adjustNodeLabelFontSizeAutomatically>
        <enablePorts>true</enablePorts>
        <enableSIFTopologyGrouping>false</enableSIFTopologyGrouping>
        <allowCompoundNodeResize>true</allowCompoundNodeResize>
        <mapColorScheme>black_white</mapColorScheme>
        <mapColorSchemeStyle>solid</mapColorSchemeStyle>
        <mapName>Pathway #8</mapName>
        <highlightColor>#0B9BCD</highlightColor>
        <extraHighlightThickness>2</extraHighlightThickness>
      </mapProperties>
      <popperInfo>
        <glyph id="Node1">
          <entry uniprot="P04271" iid="IID00410"/>
          <pdb pdb_id="2pruA"/>
        </glyph>
        <glyph id="Node3">
          <pdb pdb_id="1uwo"/>
        </glyph>
        <glyph id="Node7">
          <entry uniprot="P04271" iid="IID00410"/>
          <pdb pdb_id="1uwoA"/>
        </glyph>
        <glyph id="Node4">
          <entry uniprot="P52907" iid="IID00122"/>
          <entry uniprot="P09038" iid="IID00438"/>
          <entry uniprot="Q15418" iid="IID00726"/>
        </glyph>
        <glyph id="Node13">
          <entry uniprot="P04271" iid="IID00410"/>
          <pdb pdb_id="1mq1A"/>
          <pdb pdb_id="2m49B"/>
          <pdb pdb_id="5csfA"/>
          <complex gene="CAPZA1" iid1="IID00410" iid2="IID00122" cluster="3788"/>
          <complex gene="FGF2" iid1="IID00410" iid2="IID00438" cluster="2642"/>
          <complex gene="RPS6KA1" iid1="IID00410" iid2="IID00726" cluster="1004"/>
        </glyph>
        <glyph id="Node15">
          <entry uniprot="P52907" iid="IID00122"/>
          <entry uniprot="P09038" iid="IID00438"/>
          <entry uniprot="Q15418" iid="IID00726"/>
        </glyph>
        <arc id="Node1-Node11.1">
          <process process_no="1"/>
        </arc>
        <arc id="Node2-Node11.1">
          <process process_no="1"/>
        </arc>
        <arc id="Node11.2-Node3">
          <process process_no="1"/>
        </arc>
        <arc id="Node3-Node18.1">
          <process process_no="2"/>
        </arc>
        <arc id="Node4-Node18.1">
          <process process_no="2"/>
        </arc>
        <arc id="Node18.2-Node5">
          <process process_no="2"/>
        </arc>
      </popperInfo>
      <isEdited>true</isEdited>
    </extension>
    <glyph id="Node6" class="phenotype" obj_id="1">
      <label text="dimer;&#xA;apo-S100B form"/>
      <bbox x="53.005041986892536" y="73.9990093987598" w="126" h="30"/>
    </glyph>
    <glyph id="Node9" class="phenotype" obj_id="2">
      <label text="dimer; holo-S100B form; Ca2+ binding&#xA;to the EF-hand motifs induces a&#xA;conformational rearrangement of S100B"/>
      <bbox x="301.4435313960399" y="-90.00717466943996" w="333" h="30"/>
    </glyph>
    <glyph id="Node10" class="phenotype" obj_id="2">
      <label text="2 calcium ions per S100B&#xA;subunit (1 calcium ion&#xA;per EF-hand motif) "/>
      <bbox x="95.64817876471847" y="-104.11944177515008" w="216" h="30"/>
    </glyph>
    <glyph id="Node12" class="phenotype" obj_id="3">
      <label text="e.g. TRTK-12, FGF2,&#xA;RSK1; reviewed&#xA;in PMID:17010455"/>
      <bbox x="222.42406793875978" y="135.513346370576" w="171" h="30"/>
    </glyph>
    <glyph id="Node16" class="phenotype" obj_id="4">
      <label text="dimer"/>
      <bbox x="494.4433393404787" y="114.06784364595921" w="120" h="30"/>
    </glyph>
    <glyph id="Node17" class="phenotype" obj_id="4">
      <label text="Ca2+ dependent binding to target&#xA;proteins; regulates/alters the&#xA;function of the target protein"/>
      <bbox x="637.1825918465403" y="14.072023898007679" w="288" h="30"/>
    </glyph>
    <glyph id="Node1" class="macromolecule" obj_id="1">
      <label text="S100B"/>
      <bbox x="67.39490284728282" y="16.503542248327726" w="90" h="30"/>
    </glyph>
    <glyph id="Node2" class="simple chemical" obj_id="1">
      <label text="Ca2+"/>
      <bbox x="66.45028829303253" y="-32.961905639255896" w="90" h="30"/>
    </glyph>
    <glyph id="Node3" class="complex" obj_id="2 3">
      <bbox x="251.74081287839195" y="-30.79019579360379" w="0" h="0"/>
      <glyph id="Node7" class="macromolecule" obj_id="2 3">
        <label text="S100B"/>
        <bbox x="261.1996565411429" y="13.821655871920328" w="90" h="30"/>
      </glyph>
      <glyph id="Node8" class="simple chemical" obj_id="2 3">
        <label text="Ca2+"/>
        <bbox x="258.365812878392" y="-24.165195793603793" w="90" h="30"/>
      </glyph>
    </glyph>
    <glyph id="Node11" class="association">
      <bbox x="197.0280778701348" y="2.325487344008364" w="15" h="15"/>
      <port id="Node11.1" x="206.1530778701348" y="11.450487344008364"/>
      <port id="Node11.2" x="206.1530778701348" y="11.450487344008364"/>
    </glyph>
    <glyph id="Node4" class="macromolecule" obj_id="3">
      <label text="S100B_target_protein"/>
      <bbox x="250.07030858944387" y="75.54398995774403" w="120" h="30"/>
    </glyph>
    <glyph id="Node5" class="complex" obj_id="4">
      <bbox x="484.70227846267596" y="-31.354767168868705" w="0" h="0"/>
      <glyph id="Node13" class="macromolecule" obj_id="4">
        <label text="S100B"/>
        <bbox x="505.686146323436" y="14.741774614130186" w="90" h="30"/>
      </glyph>
      <glyph id="Node14" class="simple chemical" obj_id="4">
        <label text="Ca2+"/>
        <bbox x="506.5784374084418" y="-24.729767168868698" w="90" h="30"/>
      </glyph>
      <glyph id="Node15" class="macromolecule" obj_id="4">
        <label text="S100B_target_protein"/>
        <bbox x="491.32727846267596" y="56.72252422295287" w="120" h="30"/>
      </glyph>
    </glyph>
    <glyph id="Node18" class="association">
      <bbox x="419.9484351391782" y="26.592766742916858" w="15" h="15"/>
      <port id="Node18.1" x="429.0734351391782" y="35.71776674291686"/>
      <port id="Node18.2" x="429.0734351391782" y="35.71776674291686"/>
    </glyph>
    <arc id="Node1-Node6" class="modulation" source="Node1" target="Node6">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node3-Node9" class="modulation" source="Node3" target="Node9">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node8-Node10" class="modulation" source="Node8" target="Node10">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node1-Node11.1" class="consumption" source="Node1" target="Node11.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node2-Node11.1" class="consumption" source="Node2" target="Node11.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node11.2-Node3" class="production" source="Node11.2" target="Node3">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node4-Node12" class="modulation" source="Node4" target="Node12">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node5-Node16" class="modulation" source="Node5" target="Node16">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node13-Node17" class="modulation" source="Node13" target="Node17">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node3-Node18.1" class="consumption" source="Node3" target="Node18.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node4-Node18.1" class="consumption" source="Node4" target="Node18.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node18.2-Node5" class="production" source="Node18.2" target="Node5">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
  </map>
  <formatOutput>1</formatOutput>
</sbgn>
