<?xml version="1.0" encoding="utf-8"?>
<IDEAL>
  <Version>1.0.0</Version>
  <BiologicalPhenomenon>
    <IdealID/>
    <UniprotAccession>P04271-1</UniprotAccession>
    <Object>
      <obj_id>1</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>S100B</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P04271</uniprot_accession>
              <ideal_id>IID00410</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>dimer; apo-S100B form</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>2pruA</pdb_id>
            </pdb>
          </protein>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <others>
            <symbol>Ca2+</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </others>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>2</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype>dimer; holo-S100B form; Ca2+ binding to the EF-hand motifs induces a conformational rearrangement of S100B</phenotype>
          <complex/>
          <llps>FALSE</llps>
          <pdb>
            <pdb_id>1uwo</pdb_id>
          </pdb>
          <protein>
            <symbol>S100B</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P04271</uniprot_accession>
              <ideal_id>IID00410</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>1uwoA</pdb_id>
            </pdb>
          </protein>
          <others>
            <symbol>Ca2+</symbol>
            <location/>
            <phenotype>2 calcium ions per S100B subunit (1 calcium ion per EF-hand motif) </phenotype>
            <complex/>
            <llps>FALSE</llps>
          </others>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>3</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>S100B</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P04271</uniprot_accession>
              <ideal_id>IID00410</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
          <others>
            <symbol>Ca2+</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </others>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>S100B_target_protein</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P52907</uniprot_accession>
              <ideal_id>IID00122</ideal_id>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>2</uniprot_accessions_id>
              <uniprot_accession>P09038</uniprot_accession>
              <ideal_id>IID00438</ideal_id>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>3</uniprot_accessions_id>
              <uniprot_accession>Q15418</uniprot_accession>
              <ideal_id>IID00726</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>e.g. TRTK-12, FGF2, RSK1; reviewed in PMID:17010455</phenotype>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>4</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype>dimer</phenotype>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>S100B</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P04271</uniprot_accession>
              <ideal_id>IID00410</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>Ca2+ dependent binding to target proteins; regulates/alters the function of the target protein</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>1mq1A</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>2m49B</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>5csfA</pdb_id>
            </pdb>
          </protein>
          <others>
            <symbol>Ca2+</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </others>
          <protein>
            <symbol>S100B_target_protein</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P52907</uniprot_accession>
              <ideal_id>IID00122</ideal_id>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>2</uniprot_accessions_id>
              <uniprot_accession>P09038</uniprot_accession>
              <ideal_id>IID00438</ideal_id>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>3</uniprot_accessions_id>
              <uniprot_accession>Q15418</uniprot_accession>
              <ideal_id>IID00726</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Process>
      <process_id>1</process_id>
      <operand_obj_id>1</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>2</result_obj_id>
      <pubmed>
        <pubmed_id>9519411</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>17660747</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>18384084</pubmed_id>
      </pubmed>
    </Process>
    <Process>
      <process_id>2</process_id>
      <operand_obj_id>3</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>4</result_obj_id>
      <pubmed>
        <pubmed_id>12480931</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>24063890</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>26527685</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>20827422</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>36046652</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>17010455</pubmed_id>
      </pubmed>
    </Process>
    <IdenticalComponent>
      <identical_id>1</identical_id>
      <identicals>
        <process_id>1</process_id>
        <process_type>result</process_type>
        <obj_id>2</obj_id>
        <component_id>1</component_id>
      </identicals>
      <identicals>
        <process_id>2</process_id>
        <process_type>operand</process_type>
        <obj_id>3</obj_id>
        <component_id>1</component_id>
      </identicals>
    </IdenticalComponent>
  </BiologicalPhenomenon>
</IDEAL>

