1.0.0 P04626-1 1 1 1 FALSE ERBB2(Ps) 1 P04626 IID00293 The following tyrosines in the C-terminus can be phosphorylated (PubMed:34827688): Y1005, Y1023, Y1112, Y1127, Y1139, Y1196, Y1221, Y1222, Y1248; pY1196 and pY1248 promotes cell migration and proliferation. FALSE Phosphorylations 1 ErbB_family_RTK(Ps) RTK: Receptor Tyrosine Kinase FALSE Phosphorylations 1 2 1 FALSE PTPN18 1 Q99952 IID00581 FALSE 2 1 1 FALSE ERBB2(Ps) 1 P04626 IID00293 FALSE 4gfuF 4gfvF Phosphorylations 1 ErbB_family_RTK(Ps) FALSE Phosphorylations 1 PTPN18 1 Q99952 IID00581 FALSE 4gfuA 4gfvA 3 1 1 FALSE PTPN18 1 Q99952 IID00581 dephosphorylates ERBB2 at Y1196 and Y1248 FALSE 4 1 1 FALSE ERBB2(Ps) 1 P04626 IID00293 dephosphorylated at Y1196 and Y1248 FALSE Phosphorylations 1 ErbB_family_RTK(Ps) FALSE Phosphorylations 1 PTPN18 1 Q99952 IID00581 FALSE 5 1 1 loss of function to activate the signaling cascades for cell proliferation and invasion FALSE ERBB2(Ps) 1 P04626 IID00293 FALSE Phosphorylations 1 ErbB_family_RTK(Ps) FALSE Phosphorylations 1 2 1 FALSE PTPN18 1 Q99952 IID00581 FALSE 1 1 FALSE 2 25081058 34827688 2 2 TRUE 3 4 3 4 FALSE 5