<?xml version="1.0" encoding="utf-8"?>
<IDEAL>
  <Version>1.0.0</Version>
  <BiologicalPhenomenon>
    <IdealID/>
    <UniprotAccession>P04626-4</UniprotAccession>
    <Object>
      <obj_id>1</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>ERBB2(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P04626</uniprot_accession>
              <ideal_id>IID00293</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>The following tyrosines in the C-terminus can be phosphorylated (PubMed:34827688): Y1005, Y1023, Y1112, Y1127, Y1139, Y1196, Y1221, Y1222, Y1248</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>1139</region_start>
                <region_end>1139</region_end>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>ErbB_family_RTK(Ps)</symbol>
            <location/>
            <phenotype>RTK: Receptor Tyrosine Kinase</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start/>
                <region_end/>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>GRB7</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q14451</uniprot_accession>
              <ideal_id>IID00566</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>2</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>ERBB2(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P04626</uniprot_accession>
              <ideal_id>IID00293</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>1mw4B</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>2l4kB</pdb_id>
            </pdb>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>1139</region_start>
                <region_end>1139</region_end>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>ErbB_family_RTK(Ps)</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start/>
                <region_end/>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>GRB7</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q14451</uniprot_accession>
              <ideal_id>IID00566</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>1mw4A</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>2l4kA</pdb_id>
            </pdb>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>3</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>ERBB2(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P04626</uniprot_accession>
              <ideal_id>IID00293</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>1139</region_start>
                <region_end>1139</region_end>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>ErbB_family_RTK(Ps)</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start/>
                <region_end/>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>4</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>ERBB2(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P04626</uniprot_accession>
              <ideal_id>IID00293</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>1139</region_start>
                <region_end>1139</region_end>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>ErbB_family_RTK(Ps)</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start/>
                <region_end/>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>GRB7(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q14451</uniprot_accession>
              <ideal_id>IID00566</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>phosphorylated at least on Y188 and/or Y338; activates multiple downstream pathways of ErbB signaling</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start/>
                <region_end/>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Process>
      <process_id>1</process_id>
      <operand_obj_id>1</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>2</result_obj_id>
      <pubmed>
        <pubmed_id>31083325</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>12975581</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>22702899</pubmed_id>
      </pubmed>
    </Process>
    <Process>
      <process_id>2</process_id>
      <operand_obj_id>2</operand_obj_id>
      <included_operand>TRUE</included_operand>
      <operator_obj_id>3</operator_obj_id>
      <result_obj_id>4</result_obj_id>
      <pubmed>
        <pubmed_id>20622016</pubmed_id>
      </pubmed>
    </Process>
  </BiologicalPhenomenon>
</IDEAL>

