<?xml version="1.0" encoding="utf-8"?>
<IDEAL>
  <Version>1.0.0</Version>
  <BiologicalPhenomenon>
    <IdealID/>
    <UniprotAccession>P04631-1</UniprotAccession>
    <Object>
      <obj_id>1</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>S100b</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P04631</uniprot_accession>
              <ideal_id>IID50019</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>dimer; apo-S100b form</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>1b4cA</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>1symA</pdb_id>
            </pdb>
          </protein>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <others>
            <symbol>Ca2+</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </others>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>2</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <pdb>
            <pdb_id>1qlk</pdb_id>
          </pdb>
          <pdb>
            <pdb_id>2k7o</pdb_id>
          </pdb>
          <protein>
            <symbol>S100b</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P04631</uniprot_accession>
              <ideal_id>IID50019</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>dimer; holo-S100b form; Ca2+ binding to the EF-hand motifs induces a conformational rearrangement of S100b</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>1qlkA</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>2k7oA</pdb_id>
            </pdb>
          </protein>
          <others>
            <symbol>Ca2+</symbol>
            <location/>
            <phenotype>2 calcium ions per S100b subunit (1 calcium ion per EF-hand motif)</phenotype>
            <complex/>
            <llps>FALSE</llps>
          </others>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>3</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>S100b</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P04631</uniprot_accession>
              <ideal_id>IID50019</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
          <others>
            <symbol>Ca2+</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </others>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>S100b_target_protein</symbol>
            <location/>
            <phenotype/>
            <complex>e.g. p53, TRTK-12; reviewed in PMID:17010455</complex>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>4</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype>dimer</phenotype>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>S100b</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P04631</uniprot_accession>
              <ideal_id>IID50019</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>Ca2+ dependent binding to target proteins; regulates/alters the function of the target protein</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>1dt7A</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>1mwnA</pdb_id>
            </pdb>
          </protein>
          <others>
            <symbol>Ca2+</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </others>
          <protein>
            <symbol>S100b_target_protein</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Process>
      <process_id>1</process_id>
      <operand_obj_id>1</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>2</result_obj_id>
      <pubmed>
        <pubmed_id>10211826</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>9485423</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>8794737</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>18949447</pubmed_id>
      </pubmed>
    </Process>
    <Process>
      <process_id>2</process_id>
      <operand_obj_id>3</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>4</result_obj_id>
      <pubmed>
        <pubmed_id>10876243</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>12470955</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>20827422</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>36046652</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>17010455</pubmed_id>
      </pubmed>
    </Process>
    <IdenticalComponent>
      <identical_id>1</identical_id>
      <identicals>
        <process_id>1</process_id>
        <process_type>result</process_type>
        <obj_id>2</obj_id>
        <component_id>1</component_id>
      </identicals>
      <identicals>
        <process_id>2</process_id>
        <process_type>operand</process_type>
        <obj_id>3</obj_id>
        <component_id>1</component_id>
      </identicals>
    </IdenticalComponent>
  </BiologicalPhenomenon>
</IDEAL>

