1.0.0 P04637-4 1 1 1 FALSE TP53 1 P04637 IID00015 FALSE 2 1 FALSE MDM2 1 Q00987 IID00163 2 P56273 IID50077 FALSE 2 1 1 FALSE 1ycq 1ycr 4hfz TP53 1 P04637 IID00015 FALSE 1ycqB 1ycrB 4hfzB MDM2 1 Q00987 IID00163 2 P56273 IID50077 FALSE 1ycqA 1ycrA 4hfzA 3 1 1 FALSE TP53 1 P04637 IID00015 FALSE 4 1 1 FALSE ATM 1 Q13315 FALSE 2 FALSE ATR 1 Q13535 FALSE 3 FALSE PRKDC 1 P78527 FALSE 4 FALSE MAPK3|7|8|9|11|14 1 Q16644 2 Q13164 3 P45983 IID00270 4 P45984 5 Q15759 6 Q16539 IID00280 FALSE 5 FALSE CSNK1D 1 P48730 FALSE 6 FALSE CHEK1|2 1 O14757 2 O96017 FALSE 7 FALSE MAPKAPK2 1 P49137 IID00271 FALSE 8 FALSE PLK3 1 Q9H4B4 FALSE 9 FALSE VRK1|2 1 Q99986 2 Q86Y07 FALSE 10 FALSE HIPK2 1 Q9H2X6 FALSE 11 FALSE DYRK2 1 Q92630 FALSE 5 1 1 FALSE TP53(Ps) 1 P04637 IID00015 DNA damage/Stress-induced phosphorylation; phosphorylation on S15, T18, S20, S37 inhibits MDM2 binding; activation of p53 target genes, resulting in cell cycle arrest or apoptosis. FALSE Phosphorylations 1 6 1 1 FALSE MDM2 1 Q00987 IID00163 2 P56273 IID50077 FALSE 7 1 1 FALSE TP53(Ub) 1 P04637 IID00015 FALSE Ubiquitination 1 MDM2 1 Q00987 IID00163 2 P56273 IID50077 FALSE 8 1 1 FALSE TP53(Ub) 1 P04637 IID00015 proteasomal degradation FALSE Ubiquitination 1 2 1 FALSE MDM2 1 Q00987 IID00163 2 P56273 IID50077 FALSE 1 1 FALSE 2 8875929 23897459 2 3 FALSE 4 5 36090037 35563397 3 2 TRUE 6 7 4 7 FALSE 8 1 1 operand 1 1 2 operand 3 1