<?xml version="1.0" encoding="utf-8"?>
<IDEAL>
  <Version>1.0.0</Version>
  <BiologicalPhenomenon>
    <IdealID/>
    <UniprotAccession>P04637-8</UniprotAccession>
    <Object>
      <obj_id>1</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>TP53(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P04637</uniprot_accession>
              <ideal_id>IID00015</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>phosphorylation triggered by genotoxic stress; phosphorylation on S366, S378, T387 increases 14-3-3 binding (higher affinities, when di-phosphorylated)</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start/>
                <region_end/>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>SFN</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P31947</uniprot_accession>
              <ideal_id>IID00301</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>2</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype>enhanced p53 transcriptional activity</phenotype>
          <complex/>
          <llps>FALSE</llps>
          <pdb>
            <pdb_id>3lw1</pdb_id>
          </pdb>
          <pdb>
            <pdb_id>5mhc</pdb_id>
          </pdb>
          <pdb>
            <pdb_id>5moc</pdb_id>
          </pdb>
          <protein>
            <symbol>TP53(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P04637</uniprot_accession>
              <ideal_id>IID00015</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>3lw1P</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>5mhcP</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>5mocP</pdb_id>
            </pdb>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>387</region_start>
                <region_end>387</region_end>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>SFN</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P31947</uniprot_accession>
              <ideal_id>IID00301</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>antagonizes the biological functions of MDM2 by blocking MDM2-mediated p53 ubiquitination and nuclear export; facilitates the oligomerization of p53</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>3lw1A</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>5mhcA</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>5mocA</pdb_id>
            </pdb>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Process>
      <process_id>1</process_id>
      <operand_obj_id>1</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>2</result_obj_id>
      <pubmed>
        <pubmed_id>20206173</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>28640363</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>33298896</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>34289043</pubmed_id>
      </pubmed>
    </Process>
  </BiologicalPhenomenon>
</IDEAL>

