<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<sbgn xmlns="http://sbgn.org/libsbgn/0.2">
\t<map language="process description">
\t<extension><selfEntry uniprot="P06400" iid="IID00017"/><renderInformation id="renderInformation" program-name="sbgnviz" program-version="6.0.2" background-color="#00000000"><listOfColorDefinitions><colorDefinition id="color_transparence" value="#ffffffff"/><colorDefinition id="color_stroke" value="#555555"/><colorDefinition id="color_white" value="#ffffff"/><colorDefinition id="color_red" value="#ff0000"/><colorDefinition id="color_association" value="#707070ff"/><colorDefinition id="color_dissociation" value="#ffffff"/><colorDefinition id="color_location" value="#e7effaff"/><colorDefinition id="color_phenotype" value="#e7effaff"/><colorDefinition id="color_complex" value="#e7effaff"/></listOfColorDefinitions><listOfStyles><style id="macromolecule" idList="0 Node1 Node7 Node8 Node9 Node2 Node11 Node12 Node3 Node13 Node14 Node4 Node15 Node17 Node18 Node5 Node6 Node22 Node23"><g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/></style><style id="prop_phenotype" idList="0 Node10 Node19 Node24"><g stroke="color_stroke" stroke-width="1.25" fill="color_phenotype" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/></style><style id="edge" idList="0 Node1-Node10 Node15-Node19 Node1-Node20.1 Node2-Node20 Node3-Node20 Node20.2-Node4 Node6-Node24 Node4-Node25.1 Node25.2-Node5 Node25.2-Node6"><g stroke="color_stroke" stroke-width="1.25"/></style><style id="state_variable" idList="0 Node16 Node21"><g stroke="color_stroke" stroke-width="1" fill="color_white" font-size="9" font-family="monospace" font-weight="normal" font-style="normal" font-color="#0f0f0f"/></style><style id="process" idList="0 Node20"><g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" background-image-opacity="1" background-opacity="1"/></style><style id="dissociation" idList="0 Node25"><g stroke="color_stroke" stroke-width="1.25" fill="color_dissociation" background-image-opacity="1" background-opacity="1"/></style></listOfStyles></renderInformation><mapProperties><compoundPadding>0</compoundPadding><extraCompartmentPadding>14</extraCompartmentPadding><extraComplexPadding>10</extraComplexPadding><arrowScale>1.25</arrowScale><showComplexName>true</showComplexName><dynamicLabelSize>regular</dynamicLabelSize><inferNestingOnLoad>false</inferNestingOnLoad><fitLabelsToNodes>false</fitLabelsToNodes><fitLabelsToInfoboxes>false</fitLabelsToInfoboxes><recalculateLayoutOnComplexityManagement>true</recalculateLayoutOnComplexityManagement><rearrangeOnComplexityManagement>true</rearrangeOnComplexityManagement><animateOnDrawingChanges>true</animateOnDrawingChanges><adjustNodeLabelFontSizeAutomatically>false</adjustNodeLabelFontSizeAutomatically><enablePorts>true</enablePorts><enableSIFTopologyGrouping>false</enableSIFTopologyGrouping><allowCompoundNodeResize>true</allowCompoundNodeResize><mapColorScheme>black_white</mapColorScheme><mapColorSchemeStyle>solid</mapColorSchemeStyle><mapName>Pathway #8</mapName><highlightColor>#0B9BCD</highlightColor><extraHighlightThickness>2</extraHighlightThickness></mapProperties><popperInfo><glyph id="Node1"><pdb pdb_id="2aze"/></glyph><glyph id="Node7"><entry uniprot="P06400" iid="IID00017"/><pdb pdb_id="2azeC"/><pdb pdb_id="1n4mB"/><pdb pdb_id="1o9kA"/><pdb pdb_id="1o9kB"/><complex gene="E2F1" iid1="IID00017" iid2="IID00064" cluster="1817"/><complex gene="E2F2" iid1="IID00017" iid2="IID00171" cluster="2741"/><complex gene="E2F1" iid1="IID00017" iid2="IID00064" cluster="589"/><complex gene="E2F1" iid1="IID00017" iid2="IID00064" cluster="589"/><complex gene="TFDP1" iid1="IID00017" iid2="IID00076" cluster="1817"/></glyph><glyph id="Node8"><entry uniprot="Q01094" iid="IID00064"/><entry uniprot="Q14209" iid="IID00171"/><entry uniprot="O00716"/><pdb pdb_id="2azeB"/><pdb pdb_id="1n4mD"/><pdb pdb_id="1o9kP"/><complex gene="RB1" iid1="IID00064" iid2="IID00017" cluster="1817"/><complex gene="RB1" iid1="IID00171" iid2="IID00017" cluster="2741"/><complex gene="RB1" iid1="IID00064" iid2="IID00017" cluster="589"/><complex gene="TFDP1" iid1="IID00064" iid2="IID00076" cluster="1817"/></glyph><glyph id="Node9"><entry uniprot="Q14186" iid="IID00076"/><entry uniprot="Q14188"/><pdb pdb_id="2azeA"/><complex gene="RB1" iid1="IID00076" iid2="IID00017" cluster="1817"/><complex gene="E2F1" iid1="IID00076" iid2="IID00064" cluster="1817"/></glyph><glyph id="Node11"><entry uniprot="P24385"/><entry uniprot="P30279"/><entry uniprot="P30281"/></glyph><glyph id="Node12"><entry uniprot="P11802"/><entry uniprot="Q00534"/></glyph><glyph id="Node13"><entry uniprot="P24864" iid="IID00603"/><entry uniprot="O96020"/></glyph><glyph id="Node14"><entry uniprot="P24941" iid="IID00034"/></glyph><glyph id="Node15"><entry uniprot="P06400" iid="IID00017"/></glyph><glyph id="Node17"><entry uniprot="Q01094" iid="IID00064"/><entry uniprot="Q14209" iid="IID00171"/><entry uniprot="O00716"/></glyph><glyph id="Node18"><entry uniprot="Q14186" iid="IID00076"/><entry uniprot="Q14188"/></glyph><arc id="Node1-Node20.1"><process process_no="1"/></arc><arc id="Node2-Node20"><process process_no="1"/></arc><arc id="Node3-Node20"><process process_no="1"/></arc><arc id="Node20.2-Node4"><process process_no="1"/></arc><glyph id="Node5"><entry uniprot="P06400" iid="IID00017"/></glyph><glyph id="Node22"><entry uniprot="Q01094" iid="IID00064"/><entry uniprot="Q14209" iid="IID00171"/><entry uniprot="O00716"/></glyph><glyph id="Node23"><entry uniprot="Q14186" iid="IID00076"/><entry uniprot="Q14188"/></glyph><arc id="Node4-Node25.1"><process process_no="2"/></arc><arc id="Node25.2-Node5"><process process_no="2"/></arc><arc id="Node25.2-Node6"><process process_no="2"/></arc></popperInfo><isEdited>true</isEdited></extension><glyph id="Node10" class="phenotype" obj_id="1"><label text="Repression of E2F&#10;target genes; G1 to S&#10;phase transition block"/><bbox x="62.303230135483915" y="120.49181988815997" w="198" h="30"/></glyph><glyph id="Node19" class="phenotype" obj_id="3"><label text="Hyperphosphorylated form; CDK phosphorylation&#10;sites: 230, 249, 252, 356, 373, 608,&#10;612, 780, 788, 795, 807, 811, 821, 826"/><bbox x="519.2531769432853" y="111.22195103204942" w="405" h="30"/></glyph><glyph id="Node24" class="phenotype" obj_id="4"><label text="Activation of E2F&#10;target genes; G1 to&#10;S phase progression"/><bbox x="796.7351612107076" y="225.64754725485622" w="171" h="30"/></glyph><glyph id="Node1" class="complex" obj_id="1"><bbox x="186.2617629815175" y="176.0422585057442" w="0" h="0"/><glyph id="Node7" class="macromolecule" obj_id="1"><label text="RB1"/><bbox x="192.8867629815175" y="182.6672585057442" w="90" h="30"/></glyph><glyph id="Node8" class="macromolecule" obj_id="1"><label text="E2F1|2|3"/><bbox x="192.8867629815175" y="225.91725850574417" w="90" h="30"/></glyph><glyph id="Node9" class="macromolecule" obj_id="1"><label text="TFDP1|2"/><bbox x="192.8867629815175" y="269.16725850574414" w="90" h="30"/></glyph></glyph><glyph id="Node2" class="complex" obj_id="2"><bbox x="274.4712720357433" y="98.39219038001144" w="0" h="0"/><glyph id="Node11" class="macromolecule" obj_id="2"><label text="CCND1|2|3"/><bbox x="281.0962720357433" y="105.01719038001144" w="90" h="30"/></glyph><glyph id="Node12" class="macromolecule" obj_id="2"><label text="CDK4|6"/><bbox x="281.76030670906295" y="140.96280897349513" w="90" h="30"/></glyph></glyph><glyph id="Node3" class="complex" obj_id="2"><bbox x="395.6692217372355" y="98.86432271926546" w="0" h="0"/><glyph id="Node13" class="macromolecule" obj_id="2"><label text="CCNE1|2"/><bbox x="403.282753793255" y="105.48932271926546" w="90" h="30"/></glyph><glyph id="Node14" class="macromolecule" obj_id="2"><label text="CDK2"/><bbox x="402.29422173723543" y="140.80098645526928" w="90" h="30"/></glyph></glyph><glyph id="Node4" class="complex" obj_id="3"><bbox x="516.0168437515582" y="167.65803812922582" w="0" h="0"/><glyph id="Node15" class="macromolecule" obj_id="3"><label text="RB1"/><bbox x="523.6303758075777" y="174.28303812922584" w="90" h="30"/><glyph id="Node16" class="state variable"><state value="Ps"/><bbox x="0" y="0" w="12" h="12"/></glyph></glyph><glyph id="Node17" class="macromolecule" obj_id="3"><label text="E2F1|2|3"/><bbox x="523.6303758075777" y="226.33119877884783" w="90" h="30"/></glyph><glyph id="Node18" class="macromolecule" obj_id="3"><label text="TFDP1|2"/><bbox x="522.6418437515582" y="263.109871585734" w="90" h="30"/></glyph></glyph><glyph id="Node20" class="process"><bbox x="387.48825945101834" y="232.68683485482637" w="15" h="15"/><port id="Node20.1" x="396.61325945101834" y="241.81183485482637"/><port id="Node20.2" x="396.61325945101834" y="241.81183485482637"/></glyph><glyph id="Node5" class="macromolecule" obj_id="4"><label text="RB1"/><bbox x="735.9558234464257" y="148.7622461021307" w="90" h="30"/><glyph id="Node21" class="state variable"><state value="Ps"/><bbox x="0" y="0" w="12" h="12"/></glyph></glyph><glyph id="Node6" class="complex" obj_id="4"><bbox x="740.7123654534689" y="264.80697108889467" w="0" h="0"/><glyph id="Node22" class="macromolecule" obj_id="4"><label text="E2F1|2|3"/><bbox x="747.3373654534689" y="271.4319710888947" w="90" h="30"/></glyph><glyph id="Node23" class="macromolecule" obj_id="4"><label text="TFDP1|2"/><bbox x="747.3373654534689" y="314.68197108889467" w="90" h="30"/></glyph></glyph><glyph id="Node25" class="dissociation"><bbox x="660.2846401434502" y="227.18498691349944" w="15" h="15"/><port id="Node25.1" x="669.4096401434502" y="236.30998691349944"/><port id="Node25.2" x="669.4096401434502" y="236.30998691349944"/></glyph><arc id="Node1-Node10" class="modulation" source="Node1" target="Node10"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node15-Node19" class="modulation" source="Node15" target="Node19"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node1-Node20.1" class="consumption" source="Node1" target="Node20.1"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node2-Node20" class="catalysis" source="Node2" target="Node20"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node3-Node20" class="catalysis" source="Node3" target="Node20"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node20.2-Node4" class="production" source="Node20.2" target="Node4"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node6-Node24" class="modulation" source="Node6" target="Node24"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node4-Node25.1" class="consumption" source="Node4" target="Node25.1"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node25.2-Node5" class="production" source="Node25.2" target="Node5"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node25.2-Node6" class="production" source="Node25.2" target="Node6"><start x="0" y="0"/><end x="0" y="0"/></arc></map>
<formatOutput>1</formatOutput></sbgn>

