1.0.0 P43403-1 1 1 1 FALSE ZAP70(P) 1 P43403 IID00553 FALSE Phosphorylation 1 292 292 2 1 autoinhibited;  closed conformation FALSE CBL 1 P22681 IID00300 FALSE 2 1 1 FALSE ZAP70(P) 1 P43403 IID00553 FALSE 2y1nB Phosphorylation 1 292 292 CBL 1 P22681 IID00300 open conformation FALSE 2y1nA 3 1 1 FALSE INSR 1 P06213 FALSE 4 1 1 FALSE ZAP70(P) 1 P43403 IID00553 FALSE Phosphorylation 1 292 292 CBL(P) 1 P22681 IID00300 FALSE Phosphorylation 1 371 371 5 1 1 FALSE ZAP70(P) 1 P43403 IID00553 FALSE Phosphorylation 1 292 292 CBL(P) 1 P22681 IID00300 FALSE Phosphorylation 1 371 371 2 1 FALSE UBE2D2 1 P62837 FALSE 6 1 1 FALSE ZAP70(P) 1 P43403 IID00553 FALSE 4a4bB Phosphorylation 1 292 292 CBL(P) 1 P22681 IID00300 activated FALSE 4a4bA Phosphorylation 1 371 371 UBE2D2 1 P62837 FALSE 4a4bC 7 1 1 FALSE CBL(P) 1 P22681 IID00300 FALSE Phosphorylation 1 371 371 UBE2D2 1 P62837 FALSE 8 1 1 FALSE ZAP70(P,Ub) 1 P43403 IID00553 degradation FALSE Phosphorylation 1 292 292 Ubiquitination 1 CBL(P) 1 P22681 IID00300 FALSE Phosphorylation 1 371 371 UBE2D2 1 P62837 FALSE 1 1 FALSE 2 15345216 22266821 2 2 FALSE 3 4 11997497 3 5 FALSE 6 22266821 4 6 TRUE 7 8 1 2 result 4 1 3 operand 5 1