1.0.0 P43405-1 1 1 1 FALSE ITAM_containing_protein(Ps) 1 P07766 2 P30273 3 P11912 4 O43914 5 P12318 FALSE Phosphorylations 1 2 1 FALSE SYK 1 P43405 IID00714 inactive conformation (autoinhibited) FALSE 4fl2A 7sa7F 2 1 1 FALSE 1a81 1csy 1csz ITAM_containing_protein(Ps) 1 P07766 2 P30273 3 P11912 4 O43914 5 P12318 FALSE 1a81H 1csyB 1cszB Phosphorylations 1 SYK 1 P43405 IID00714 active conformation by binding to a dually phosphorylated ITAM FALSE 1a81G 1csyA 1cszA 3 1 1 FALSE SYK 1 P43405 IID00714 FALSE 4 1 1 FALSE ITAM_containing_protein(Ps) 1 P07766 2 P30273 3 P11912 4 O43914 5 P12318 FALSE Phosphorylations 1 SYK(Ps) 1 P43405 IID00714 active conformation by phosphorylation of linker tyrosines in interdomain A or B; phosphorylation of target proteins to execute signaling cascades; autophosphorylation sustains the active conformation of Syk and signaling (positive feedback) FALSE Phosphorylations 1 5 1 1 FALSE ITAM_containing_protein(Ps) 1 P07766 2 P30273 3 P11912 4 O43914 5 P12318 FALSE Phosphorylations 1 2 1 FALSE SYK(Ps) 1 P43405 IID00714 autophosphorylation or  phosphorylation by Src family kinases sustains the active conformation of Syk and signaling (positive feedback) FALSE Phosphorylations 1 6 1 1 FALSE SYK(Ps) 1 P43405 IID00714 FALSE Phosphorylations 1 323 323 2 1 FALSE CBL(Ps) 1 P22681 IID00300 FALSE Phosphorylations 1 7 1 1 FALSE 3buw SYK(Ps) 1 P43405 IID00714 FALSE 3buwA Phosphorylations 1 323 323 CBL(Ps) 1 P22681 IID00300 binds to pY323 of SYK FALSE 3buwB Phosphorylations 1 8 1 1 FALSE CBL(Ps) 1 P22681 IID00300 FALSE Phosphorylations 1 9 1 1 FALSE SYK(Ps,Ub) 1 P43405 IID00714 FALSE Phosphorylations 1 323 323 Ubiquitination 1 CBL(Ps) 1 P22681 IID00300 FALSE Phosphorylations 1 10 1 1 FALSE SYK(Ps,Ub) 1 P43405 IID00714 proteasomal degradation; termination of signaling FALSE Phosphorylations 1 323 323 Ubiquitination 1 2 1 FALSE CBL(Ps) 1 P22681 IID00300 FALSE Phosphorylations 1 11 1 1 FALSE ITAM_containing_protein 1 P07766 2 P30273 3 P11912 4 O43914 5 P12318 e.g. Immunoreceptor-associated transmembrane adaptors, such as CD3 and Fc gamma RIIA; ITAMs: Immunoreceptor Tyrosine-based Activation Motifs FALSE 12 1 1 FALSE ITAM_containing_protein(Ps) 1 P07766 2 P30273 3 P11912 4 O43914 5 P12318 dually phosphorylated ITAMs FALSE Phosphorylations 1 13 1 1 FALSE Src_family_kinase 1 P07948 IID00701 e.g. Lyn; activated by immunoreceptor ligation FALSE 1 11 FALSE 13 12 9698567 8590001 18273061 23154170 34601763 21469132 20467426 2 1 FALSE 2 3 2 TRUE 3 4 4 4 FALSE 5 5 6 FALSE 7 6 7 TRUE 8 9 7 9 FALSE 10 1 1 result 12 1 2 operand 1 1 2 4 result 5 2 5 operand 6 1