<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<sbgn xmlns="http://sbgn.org/libsbgn/0.2">
\t<map language="process description">
\t<extension><selfEntry uniprot="P46527" iid="IID00049"/><renderInformation id="renderInformation" program-name="sbgnviz" program-version="6.0.2" background-color="#00000000"><listOfColorDefinitions><colorDefinition id="color_transparence" value="#ffffffff"/><colorDefinition id="color_stroke" value="#555555"/><colorDefinition id="color_white" value="#ffffff"/><colorDefinition id="color_red" value="#ff0000"/><colorDefinition id="color_association" value="#707070ff"/><colorDefinition id="color_dissociation" value="#ffffff"/><colorDefinition id="color_location" value="#e7effaff"/><colorDefinition id="color_phenotype" value="#e7effaff"/><colorDefinition id="color_complex" value="#e7effaff"/></listOfColorDefinitions><listOfStyles><style id="macromolecule" idList="0 Node1 Node2 Node3 Node4 Node10 Node11 Node5 Node6 Node13 Node14 Node15 Node7 Node18 Node21 Node22"><g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/></style><style id="state_variable" idList="0 Node8 Node16 Node19 Node20"><g stroke="color_stroke" stroke-width="1" fill="color_white" font-size="9" font-family="monospace" font-weight="normal" font-style="normal" font-color="#0f0f0f"/></style><style id="process" idList="0 Node9 Node24"><g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" background-image-opacity="1" background-opacity="1"/></style><style id="edge" idList="0 Node1-Node9.1 Node2-Node9 Node9.2-Node3 Node11-Node12 Node3-Node17.1 Node4-Node17.1 Node17.2-Node5 Node18-Node23 Node5-Node24.1 Node6-Node24 Node24.2-Node7"><g stroke="color_stroke" stroke-width="1.25"/></style><style id="prop_complex" idList="0 Node12"><g stroke="color_stroke" stroke-width="1.25" fill="color_complex" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/></style><style id="association" idList="0 Node17"><g stroke="color_stroke" stroke-width="1.25" fill="color_association" background-image-opacity="1" background-opacity="1"/></style><style id="prop_phenotype" idList="0 Node23"><g stroke="color_stroke" stroke-width="1.25" fill="color_phenotype" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/></style></listOfStyles></renderInformation><mapProperties><compoundPadding>0</compoundPadding><extraCompartmentPadding>14</extraCompartmentPadding><extraComplexPadding>10</extraComplexPadding><arrowScale>1.25</arrowScale><showComplexName>true</showComplexName><dynamicLabelSize>regular</dynamicLabelSize><inferNestingOnLoad>false</inferNestingOnLoad><fitLabelsToNodes>false</fitLabelsToNodes><fitLabelsToInfoboxes>false</fitLabelsToInfoboxes><recalculateLayoutOnComplexityManagement>true</recalculateLayoutOnComplexityManagement><rearrangeOnComplexityManagement>true</rearrangeOnComplexityManagement><animateOnDrawingChanges>true</animateOnDrawingChanges><adjustNodeLabelFontSizeAutomatically>false</adjustNodeLabelFontSizeAutomatically><enablePorts>true</enablePorts><enableSIFTopologyGrouping>false</enableSIFTopologyGrouping><allowCompoundNodeResize>true</allowCompoundNodeResize><mapColorScheme>black_white</mapColorScheme><mapColorSchemeStyle>solid</mapColorSchemeStyle><mapName>Pathway #8</mapName><highlightColor>#0B9BCD</highlightColor><extraHighlightThickness>2</extraHighlightThickness></mapProperties><popperInfo><glyph id="Node1"><entry uniprot="P46527" iid="IID00049"/></glyph><glyph id="Node2"><entry uniprot="P24941" iid="IID00034"/></glyph><glyph id="Node3"><entry uniprot="P46527" iid="IID00049"/></glyph><arc id="Node1-Node9.1"><process process_no="1"/></arc><arc id="Node2-Node9"><process process_no="1"/></arc><arc id="Node9.2-Node3"><process process_no="1"/></arc><glyph id="Node11"><entry uniprot="P63208"/><entry uniprot="Q13309" iid="IID00321"/></glyph><glyph id="Node14"><entry uniprot="P63208"/><entry uniprot="Q13309" iid="IID00321"/><pdb pdb_id="2astA"/><pdb pdb_id="2astB"/><complex gene="CDKN1B" iid1="IID00321" iid2="IID00049" cluster="1803"/></glyph><glyph id="Node15"><entry uniprot="P46527" iid="IID00049"/><pdb pdb_id="2astD"/><complex gene="SKP2" iid1="IID00049" iid2="IID00321" cluster="1803"/></glyph><arc id="Node3-Node17.1"><process process_no="2"/></arc><arc id="Node4-Node17.1"><process process_no="2"/></arc><arc id="Node17.2-Node5"><process process_no="2"/></arc><glyph id="Node18"><entry uniprot="P46527" iid="IID00049"/></glyph><glyph id="Node22"><entry uniprot="P63208"/><entry uniprot="Q13309" iid="IID00321"/></glyph><arc id="Node5-Node24.1"><process process_no="3"/></arc><arc id="Node6-Node24"><process process_no="3"/></arc><arc id="Node24.2-Node7"><process process_no="3"/></arc></popperInfo><isEdited>true</isEdited></extension><glyph id="Node12" class="phenotype" obj_id="4"><label text="Skp1/Cul1/&#10;Rbx1/Skp2"/><bbox x="297.81148007036415" y="-133.85973055976223" w="90" h="30"/></glyph><glyph id="Node23" class="phenotype" obj_id="7"><label text="proteolysis"/><bbox x="862.1836290357556" y="-9.584520618703277" w="120" h="30"/></glyph><glyph id="Node1" class="macromolecule" obj_id="1"><label text="CDKN1B"/><bbox x="25.79478809305435" y="21.571254109520865" w="90" h="30"/></glyph><glyph id="Node2" class="macromolecule" obj_id="2"><label text="CDK2"/><bbox x="110.4991852483843" y="-30.975569968503155" w="90" h="30"/></glyph><glyph id="Node3" class="macromolecule" obj_id="3 4"><label text="CDKN1B"/><bbox x="204.7084679331764" y="7.142304531137789" w="90" h="30"/><glyph id="Node8" class="state variable"><state value="P"/><bbox x="0" y="0" w="12" h="12"/></glyph></glyph><glyph id="Node9" class="process"><bbox x="150.0230984609479" y="29.781410923864954" w="15" h="15"/><port id="Node9.1" x="159.1480984609479" y="38.906410923864954"/><port id="Node9.2" x="159.1480984609479" y="38.906410923864954"/></glyph><glyph id="Node4" class="complex" obj_id="4"><bbox x="274.59323958814724" y="-82.47292291982167" w="0" h="0"/><glyph id="Node10" class="macromolecule" obj_id="4"><label text="E2"/><bbox x="292.62459143209924" y="-34.39352576449174" w="90" h="30"/></glyph><glyph id="Node11" class="macromolecule" obj_id="4"><label text="SCFskp2-Cks1_complex"/><bbox x="281.21823958814724" y="-75.84792291982167" w="120" h="30"/></glyph></glyph><glyph id="Node5" class="complex" obj_id="5 6"><bbox x="430.74551916413657" y="-44.51533644213608" w="0" h="0"/><glyph id="Node6" class="complex" obj_id="5 6"><bbox x="437.37051916413657" y="17.111699542833605" w="0" h="0"/><glyph id="Node13" class="macromolecule" obj_id="5 6"><label text="E2"/><bbox x="463.66571463299886" y="62.09215533882217" w="90" h="30"/></glyph><glyph id="Node14" class="macromolecule" obj_id="5 6"><label text="SCFskp2-Cks1_complex"/><bbox x="443.99551916413657" y="23.736699542833605" w="120" h="30"/></glyph></glyph><glyph id="Node15" class="macromolecule" obj_id="5"><label text="CDKN1B"/><bbox x="456.26994919563356" y="-37.89033644213609" w="90" h="30"/><glyph id="Node16" class="state variable"><state value="P"/><bbox x="0" y="0" w="12" h="12"/></glyph></glyph></glyph><glyph id="Node17" class="association"><bbox x="334.87225989855307" y="26.19210681828038" w="15" h="15"/><port id="Node17.1" x="343.99725989855307" y="35.31710681828038"/><port id="Node17.2" x="343.99725989855307" y="35.31710681828038"/></glyph><glyph id="Node7" class="complex" obj_id="7"><bbox x="686.9959253478517" y="-30.754716087565477" w="0" h="0"/><glyph id="Node18" class="macromolecule" obj_id="7"><label text="CDKN1B"/><bbox x="707.6315117544382" y="-24.129716087565484" w="90" h="30"/><glyph id="Node19" class="state variable"><state value="P"/><bbox x="0" y="0" w="12" h="12"/></glyph><glyph id="Node20" class="state variable"><state value="Ub"/><bbox x="0" y="0" w="12" h="12"/></glyph></glyph><glyph id="Node21" class="macromolecule" obj_id="7"><label text="E2"/><bbox x="707.0932380980312" y="77.05880145788453" w="90" h="30"/></glyph><glyph id="Node22" class="macromolecule" obj_id="7"><label text="SCFskp2-Cks1_complex"/><bbox x="693.6209253478517" y="35.29047938129672" w="120" h="30"/></glyph></glyph><glyph id="Node24" class="process"><bbox x="615.7353061605454" y="24.397454765488106" w="15" h="15"/><port id="Node24.1" x="624.8603061605454" y="33.522454765488106"/><port id="Node24.2" x="624.8603061605454" y="33.522454765488106"/></glyph><arc id="Node1-Node9.1" class="consumption" source="Node1" target="Node9.1"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node2-Node9" class="catalysis" source="Node2" target="Node9"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node9.2-Node3" class="production" source="Node9.2" target="Node3"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node11-Node12" class="modulation" source="Node11" target="Node12"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node3-Node17.1" class="consumption" source="Node3" target="Node17.1"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node4-Node17.1" class="consumption" source="Node4" target="Node17.1"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node17.2-Node5" class="production" source="Node17.2" target="Node5"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node18-Node23" class="modulation" source="Node18" target="Node23"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node5-Node24.1" class="consumption" source="Node5" target="Node24.1"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node6-Node24" class="catalysis" source="Node6" target="Node24"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node24.2-Node7" class="production" source="Node24.2" target="Node7"><start x="0" y="0"/><end x="0" y="0"/></arc></map>
<formatOutput>1</formatOutput></sbgn>

