<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<sbgn xmlns="http://sbgn.org/libsbgn/0.2">
\t<map language="process description">
\t<extension><selfEntry uniprot="P84022" iid="IID00113"/><renderInformation id="renderInformation" program-name="sbgnviz" program-version="6.0.2" background-color="#00000000"><listOfColorDefinitions><colorDefinition id="color_transparence" value="#ffffffff"/><colorDefinition id="color_stroke" value="#555555"/><colorDefinition id="color_white" value="#ffffff"/><colorDefinition id="color_red" value="#ff0000"/><colorDefinition id="color_association" value="#707070ff"/><colorDefinition id="color_dissociation" value="#ffffff"/><colorDefinition id="color_location" value="#e7effaff"/><colorDefinition id="color_phenotype" value="#e7effaff"/><colorDefinition id="color_complex" value="#e7effaff"/></listOfColorDefinitions><listOfStyles><style id="macromolecule" idList="0 Node1 Node2 Node3 Node4 Node5 Node6 Node7 Node16 Node18 Node20 Node8 Node23 Node25 Node27"><g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/></style><style id="prop_phenotype" idList="0 Node9 Node12 Node29"><g stroke="color_stroke" stroke-width="1.25" fill="color_phenotype" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/></style><style id="edge" idList="0 Node2-Node9 Node2-Node10 Node3-Node12 Node1-Node13.1 Node2-Node13 Node13.2-Node3 Node4-Node15.1 Node2-Node15 Node15.2-Node5 Node7-Node21 Node3-Node22.1 Node5-Node22.1 Node6-Node22.1 Node22.2-Node7 Node8-Node28 Node8-Node29 Node7-Node30.1 Node30.2-Node8"><g stroke="color_stroke" stroke-width="1.25"/></style><style id="prop_complex" idList="0 Node10"><g stroke="color_stroke" stroke-width="1.25" fill="color_complex" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/></style><style id="state_variable" idList="0 Node11 Node14 Node17 Node19 Node24 Node26"><g stroke="color_stroke" stroke-width="1" fill="color_white" font-size="9" font-family="monospace" font-weight="normal" font-style="normal" font-color="#0f0f0f"/></style><style id="process" idList="0 Node13 Node15 Node30"><g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" background-image-opacity="1" background-opacity="1"/></style><style id="prop_location" idList="0 Node21 Node28"><g stroke="color_stroke" stroke-width="1.25" fill="color_location" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/></style><style id="association" idList="0 Node22"><g stroke="color_stroke" stroke-width="1.25" fill="color_association" background-image-opacity="1" background-opacity="1"/></style></listOfStyles></renderInformation><mapProperties><compoundPadding>0</compoundPadding><extraCompartmentPadding>14</extraCompartmentPadding><extraComplexPadding>10</extraComplexPadding><arrowScale>1.25</arrowScale><showComplexName>true</showComplexName><dynamicLabelSize>regular</dynamicLabelSize><inferNestingOnLoad>false</inferNestingOnLoad><fitLabelsToNodes>false</fitLabelsToNodes><fitLabelsToInfoboxes>false</fitLabelsToInfoboxes><recalculateLayoutOnComplexityManagement>true</recalculateLayoutOnComplexityManagement><rearrangeOnComplexityManagement>true</rearrangeOnComplexityManagement><animateOnDrawingChanges>true</animateOnDrawingChanges><adjustNodeLabelFontSizeAutomatically>false</adjustNodeLabelFontSizeAutomatically><enablePorts>true</enablePorts><enableSIFTopologyGrouping>false</enableSIFTopologyGrouping><allowCompoundNodeResize>true</allowCompoundNodeResize><mapColorScheme>black_white</mapColorScheme><mapColorSchemeStyle>solid</mapColorSchemeStyle><mapName>Pathway #8</mapName><highlightColor>#0B9BCD</highlightColor><extraHighlightThickness>2</extraHighlightThickness></mapProperties><popperInfo><glyph id="Node1"><entry uniprot="P84022" iid="IID00113"/></glyph><glyph id="Node3"><entry uniprot="P84022" iid="IID00113"/></glyph><arc id="Node1-Node13.1"><process process_no="1"/></arc><arc id="Node2-Node13"><process process_no="1"/></arc><arc id="Node13.2-Node3"><process process_no="1"/></arc><glyph id="Node4"><entry uniprot="P84022" iid="IID00113"/></glyph><glyph id="Node5"><entry uniprot="P84022" iid="IID00113"/></glyph><arc id="Node4-Node15.1"><process process_no="2"/></arc><arc id="Node2-Node15"><process process_no="2"/></arc><arc id="Node15.2-Node5"><process process_no="2"/></arc><glyph id="Node6"><entry uniprot="Q13485" iid="IID00132"/></glyph><glyph id="Node7"><pdb pdb_id="1u7f"/></glyph><glyph id="Node16"><entry uniprot="P84022" iid="IID00113"/><pdb pdb_id="1u7fA"/><complex gene="SMAD3" iid1="IID00113" iid2="IID00113" cluster="3124"/><complex gene="SMAD4" iid1="IID00113" iid2="IID00132" cluster="3124"/></glyph><glyph id="Node18"><entry uniprot="P84022" iid="IID00113"/><pdb pdb_id="1u7fC"/><complex gene="SMAD3" iid1="IID00113" iid2="IID00113" cluster="3124"/><complex gene="SMAD4" iid1="IID00113" iid2="IID00132" cluster="3124"/></glyph><glyph id="Node20"><entry uniprot="Q13485" iid="IID00132"/><pdb pdb_id="1u7fB"/><complex gene="SMAD3" iid1="IID00132" iid2="IID00113" cluster="3124"/></glyph><arc id="Node3-Node22.1"><process process_no="3"/></arc><arc id="Node5-Node22.1"><process process_no="3"/></arc><arc id="Node6-Node22.1"><process process_no="3"/></arc><arc id="Node22.2-Node7"><process process_no="3"/></arc><glyph id="Node8"><pdb pdb_id="1u7f"/></glyph><glyph id="Node23"><entry uniprot="P84022" iid="IID00113"/><pdb pdb_id="1u7fA"/><complex gene="SMAD3" iid1="IID00113" iid2="IID00113" cluster="3124"/><complex gene="SMAD4" iid1="IID00113" iid2="IID00132" cluster="3124"/></glyph><glyph id="Node25"><entry uniprot="P84022" iid="IID00113"/><pdb pdb_id="1u7fC"/><complex gene="SMAD3" iid1="IID00113" iid2="IID00113" cluster="3124"/><complex gene="SMAD4" iid1="IID00113" iid2="IID00132" cluster="3124"/></glyph><glyph id="Node27"><entry uniprot="Q13485" iid="IID00132"/><pdb pdb_id="1u7fB"/><complex gene="SMAD3" iid1="IID00132" iid2="IID00113" cluster="3124"/></glyph><arc id="Node7-Node30.1"><process process_no="4"/></arc><arc id="Node30.2-Node8"><process process_no="4"/></arc></popperInfo><isEdited>true</isEdited></extension><glyph id="Node9" class="phenotype" obj_id="5"><label text="ligand-bound&#10;heterotetrameric receptor&#10;complex; activated"/><bbox x="219.1358365965694" y="-107.25958642407033" w="225" h="30"/></glyph><glyph id="Node10" class="phenotype" obj_id="5"><label text="e.g.&#10;ACVR1B(ALK4)/ACVR2A"/><bbox x="470.32425759026796" y="-105.18705150454552" w="171" h="30"/></glyph><glyph id="Node12" class="phenotype" obj_id="2"><label text="phosphorylated at the&#10;C-terminal SXS sequence"/><bbox x="567.8359911777461" y="-15.251506438068185" w="207" h="30"/></glyph><glyph id="Node21" class="phenotype" obj_id="7"><label text="cytoplasm"/><bbox x="740.5858647673618" y="246.7904940517821" w="120" h="30"/></glyph><glyph id="Node28" class="phenotype" obj_id="8"><label text="nucleus"/><bbox x="972.3515356192947" y="250.07267818878728" w="120" h="30"/></glyph><glyph id="Node29" class="phenotype" obj_id="8"><label text="activates&#10;target genes"/><bbox x="1121.5999019472777" y="114.83478868726962" w="108" h="30"/></glyph><glyph id="Node1" class="macromolecule" obj_id="1"><label text="SMAD3"/><bbox x="265.3833350594784" y="12.372848192209066" w="90" h="30"/></glyph><glyph id="Node2" class="macromolecule" obj_id="5"><label text="TGF-beta_receptor_complex"/><bbox x="388.1335713086004" y="-49.03239524142569" w="150" h="30"/></glyph><glyph id="Node3" class="macromolecule" obj_id="2 6"><label text="SMAD3"/><bbox x="488.2499988079071" y="-0.004166666666691299" w="90" h="30"/><glyph id="Node11" class="state variable"><state value="Ps"/><bbox x="0" y="0" w="12" h="12"/></glyph></glyph><glyph id="Node13" class="process"><bbox x="421.58747998355284" y="21.26396706321451" w="15" h="15"/><port id="Node13.1" x="430.71247998355284" y="30.38896706321451"/><port id="Node13.2" x="430.71247998355284" y="30.38896706321451"/></glyph><glyph id="Node4" class="macromolecule" obj_id="3"><label text="SMAD3"/><bbox x="265.3833350594784" y="130.90805943550274" w="90" h="30"/></glyph><glyph id="Node5" class="macromolecule" obj_id="4 6"><label text="SMAD3"/><bbox x="488.2499988079071" y="115.87916666666666" w="90" h="30"/><glyph id="Node14" class="state variable"><state value="Ps"/><bbox x="0" y="0" w="12" h="12"/></glyph></glyph><glyph id="Node15" class="process"><bbox x="419.29984303463755" y="138.2911188710055" w="15" h="15"/><port id="Node15.1" x="428.42484303463755" y="147.4161188710055"/><port id="Node15.2" x="428.42484303463755" y="147.4161188710055"/></glyph><glyph id="Node6" class="macromolecule" obj_id="6"><label text="SMAD4"/><bbox x="492.8252727057378" y="231.20313100069734" w="90" h="30"/></glyph><glyph id="Node7" class="complex" obj_id="7"><bbox x="742.5924525166123" y="54.65328677396697" w="0" h="0"/><glyph id="Node16" class="macromolecule" obj_id="7"><label text="SMAD3"/><bbox x="749.2174525166123" y="61.27828677396698" w="90" h="30"/><glyph id="Node17" class="state variable"><state value="Ps"/><bbox x="0" y="0" w="12" h="12"/></glyph></glyph><glyph id="Node18" class="macromolecule" obj_id="7"><label text="SMAD3"/><bbox x="749.2174525166123" y="111.15328677396701" w="90" h="30"/><glyph id="Node19" class="state variable"><state value="Ps"/><bbox x="0" y="0" w="12" h="12"/></glyph></glyph><glyph id="Node20" class="macromolecule" obj_id="7"><label text="SMAD4"/><bbox x="749.2174525166123" y="174.27828677396707" w="90" h="30"/></glyph></glyph><glyph id="Node22" class="association"><bbox x="653.501248980406" y="130.67746508047517" w="15" h="15"/><port id="Node22.1" x="662.626248980406" y="139.80246508047517"/><port id="Node22.2" x="662.626248980406" y="139.80246508047517"/></glyph><glyph id="Node8" class="complex" obj_id="8"><bbox x="977.8243837826674" y="55.096784860664314" w="0" h="0"/><glyph id="Node23" class="macromolecule" obj_id="8"><label text="SMAD3"/><bbox x="984.4493837826674" y="61.7217848606643" w="90" h="30"/><glyph id="Node24" class="state variable"><state value="Ps"/><bbox x="0" y="0" w="12" h="12"/></glyph></glyph><glyph id="Node25" class="macromolecule" obj_id="8"><label text="SMAD3"/><bbox x="984.4493837826674" y="111.59678486066431" w="90" h="30"/><glyph id="Node26" class="state variable"><state value="Ps"/><bbox x="0" y="0" w="12" h="12"/></glyph></glyph><glyph id="Node27" class="macromolecule" obj_id="8"><label text="SMAD4"/><bbox x="984.4493837826674" y="174.72178486066431" w="90" h="30"/></glyph></glyph><glyph id="Node30" class="process"><bbox x="899.6511950783989" y="128.8333262182572" w="15" h="15"/><port id="Node30.1" x="908.7761950783989" y="137.9583262182572"/><port id="Node30.2" x="908.7761950783989" y="137.9583262182572"/></glyph><arc id="Node2-Node9" class="modulation" source="Node2" target="Node9"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node2-Node10" class="modulation" source="Node2" target="Node10"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node3-Node12" class="modulation" source="Node3" target="Node12"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node1-Node13.1" class="consumption" source="Node1" target="Node13.1"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node2-Node13" class="catalysis" source="Node2" target="Node13"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node13.2-Node3" class="production" source="Node13.2" target="Node3"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node4-Node15.1" class="consumption" source="Node4" target="Node15.1"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node2-Node15" class="catalysis" source="Node2" target="Node15"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node15.2-Node5" class="production" source="Node15.2" target="Node5"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node7-Node21" class="modulation" source="Node7" target="Node21"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node3-Node22.1" class="consumption" source="Node3" target="Node22.1"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node5-Node22.1" class="consumption" source="Node5" target="Node22.1"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node6-Node22.1" class="consumption" source="Node6" target="Node22.1"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node22.2-Node7" class="production" source="Node22.2" target="Node7"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node8-Node28" class="modulation" source="Node8" target="Node28"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node8-Node29" class="modulation" source="Node8" target="Node29"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node7-Node30.1" class="consumption" source="Node7" target="Node30.1"><start x="0" y="0"/><end x="0" y="0"/></arc><arc id="Node30.2-Node8" class="production" source="Node30.2" target="Node8"><start x="0" y="0"/><end x="0" y="0"/></arc></map>
<formatOutput>1</formatOutput></sbgn>

