<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<sbgn xmlns="http://sbgn.org/libsbgn/0.2">
  <map language="process description">
    <extension>
      <selfEntry uniprot="Q12968" iid="IID00466"/>
      <renderInformation id="renderInformation" program-name="sbgnviz" program-version="6.0.2" background-color="#00000000">
        <listOfColorDefinitions>
          <colorDefinition id="color_transparence" value="#ffffffff"/>
          <colorDefinition id="color_stroke" value="#555555"/>
          <colorDefinition id="color_white" value="#ffffff"/>
          <colorDefinition id="color_red" value="#ff0000"/>
          <colorDefinition id="color_association" value="#707070ff"/>
          <colorDefinition id="color_dissociation" value="#ffffff"/>
          <colorDefinition id="color_location" value="#e7effaff"/>
          <colorDefinition id="color_phenotype" value="#e7effaff"/>
          <colorDefinition id="color_complex" value="#e7effaff"/>
        </listOfColorDefinitions>
        <listOfStyles>
          <style id="macromolecule" idList="0 Node1 Node2 Node3 Node4 Node9 Node11 Node5 Node13 Node15">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="state_variable" idList="0 Node6 Node10 Node14 Node16">
            <g stroke="color_stroke" stroke-width="1" fill="color_white" font-size="9" font-family="monospace" font-weight="normal" font-style="normal" font-color="#0f0f0f"/>
          </style>
          <style id="prop_phenotype" idList="0 Node7 Node8 Node17">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_phenotype" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="edge" idList="0 Node2-Node7 Node2-Node8 Node1-Node12.1 Node2-Node12.1 Node12.2-Node3 Node13-Node17 Node3-Node18.1 Node4-Node18 Node18.2-Node5">
            <g stroke="color_stroke" stroke-width="1.25"/>
          </style>
          <style id="association" idList="0 Node12">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_association" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="process" idList="0 Node18">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" background-image-opacity="1" background-opacity="1"/>
          </style>
        </listOfStyles>
      </renderInformation>
      <mapProperties>
        <compoundPadding>0</compoundPadding>
        <extraCompartmentPadding>14</extraCompartmentPadding>
        <extraComplexPadding>10</extraComplexPadding>
        <arrowScale>1.25</arrowScale>
        <showComplexName>true</showComplexName>
        <dynamicLabelSize>regular</dynamicLabelSize>
        <inferNestingOnLoad>false</inferNestingOnLoad>
        <fitLabelsToNodes>false</fitLabelsToNodes>
        <fitLabelsToInfoboxes>false</fitLabelsToInfoboxes>
        <recalculateLayoutOnComplexityManagement>true</recalculateLayoutOnComplexityManagement>
        <rearrangeOnComplexityManagement>true</rearrangeOnComplexityManagement>
        <animateOnDrawingChanges>true</animateOnDrawingChanges>
        <adjustNodeLabelFontSizeAutomatically>false</adjustNodeLabelFontSizeAutomatically>
        <enablePorts>true</enablePorts>
        <enableSIFTopologyGrouping>false</enableSIFTopologyGrouping>
        <allowCompoundNodeResize>true</allowCompoundNodeResize>
        <mapColorScheme>black_white</mapColorScheme>
        <mapColorSchemeStyle>solid</mapColorSchemeStyle>
        <mapName>Pathway #8</mapName>
        <highlightColor>#0B9BCD</highlightColor>
        <extraHighlightThickness>2</extraHighlightThickness>
      </mapProperties>
      <popperInfo>
        <glyph id="Node1">
          <entry uniprot="Q12968" iid="IID00466"/>
        </glyph>
        <glyph id="Node2">
          <entry uniprot="P45983" iid="IID00270"/>
        </glyph>
        <glyph id="Node9">
          <entry uniprot="P45983" iid="IID00270"/>
          <pdb pdb_id="2xrwA"/>
          <complex gene="NFATC3" iid1="IID00270" iid2="IID00466" cluster="1637"/>
        </glyph>
        <glyph id="Node11">
          <entry uniprot="Q12968" iid="IID00466"/>
          <pdb pdb_id="2xrwB"/>
          <complex gene="MAPK8" iid1="IID00466" iid2="IID00270" cluster="1637"/>
        </glyph>
        <glyph id="Node13">
          <entry uniprot="Q12968" iid="IID00466"/>
        </glyph>
        <glyph id="Node15">
          <entry uniprot="P45983" iid="IID00270"/>
        </glyph>
        <arc id="Node1-Node12.1">
          <process process_no="1"/>
        </arc>
        <arc id="Node2-Node12.1">
          <process process_no="1"/>
        </arc>
        <arc id="Node12.2-Node3">
          <process process_no="1"/>
        </arc>
        <arc id="Node3-Node18.1">
          <process process_no="2"/>
        </arc>
        <arc id="Node4-Node18">
          <process process_no="2"/>
        </arc>
        <arc id="Node18.2-Node5">
          <process process_no="2"/>
        </arc>
      </popperInfo>
      <isEdited>true</isEdited>
    </extension>
    <glyph id="Node7" class="phenotype" obj_id="1">
      <label text="EC:2.7.11.24 "/>
      <bbox x="10.15260098884437" y="-89.88323974661243" w="120" h="30"/>
    </glyph>
    <glyph id="Node8" class="phenotype" obj_id="1">
      <label text="JNK1"/>
      <bbox x="145.3170159702438" y="-89.59807928211085" w="120" h="30"/>
    </glyph>
    <glyph id="Node17" class="phenotype" obj_id="4">
      <label text="down-regulated&#xA;activity due to the&#xA;cytoplasmic accumulation"/>
      <bbox x="385.0570103108254" y="-74.07584159017809" w="216" h="30"/>
    </glyph>
    <glyph id="Node1" class="macromolecule" obj_id="1">
      <label text="NFATC3"/>
      <bbox x="6.39976161654414" y="16.487615751301632" w="90" h="30"/>
    </glyph>
    <glyph id="Node2" class="macromolecule" obj_id="1">
      <label text="MAPK8"/>
      <bbox x="100.1092291764177" y="-43.74719074012105" w="90" h="30"/>
      <glyph id="Node6" class="state variable">
        <state value="Ps"/>
        <bbox x="0" y="0" w="12" h="12"/>
      </glyph>
    </glyph>
    <glyph id="Node3" class="complex" obj_id="2 3">
      <bbox x="205.601063026588" y="-20.94145060956525" w="0" h="0"/>
      <glyph id="Node4" class="complex" obj_id="2 3">
        <bbox x="212.226063026588" y="29.30957082427028" w="0" h="0"/>
        <glyph id="Node9" class="macromolecule" obj_id="2 3">
          <label text="MAPK8"/>
          <bbox x="218.851063026588" y="35.93457082427028" w="90" h="30"/>
          <glyph id="Node10" class="state variable">
            <state value="Ps"/>
            <bbox x="0" y="0" w="12" h="12"/>
          </glyph>
        </glyph>
      </glyph>
      <glyph id="Node11" class="macromolecule" obj_id="2">
        <label text="NFATC3"/>
        <bbox x="220.21798965815708" y="-14.316450609565253" w="90" h="30"/>
      </glyph>
    </glyph>
    <glyph id="Node12" class="association">
      <bbox x="137.18259124116761" y="23.47411251231175" w="15" h="15"/>
      <port id="Node12.1" x="146.30759124116761" y="32.59911251231175"/>
      <port id="Node12.2" x="146.30759124116761" y="32.59911251231175"/>
    </glyph>
    <glyph id="Node5" class="complex" obj_id="4">
      <bbox x="435.52058369892313" y="-10.058844825195408" w="0" h="0"/>
      <glyph id="Node13" class="macromolecule" obj_id="4">
        <label text="NFATC3"/>
        <bbox x="445.4181882760623" y="-2.433844825195404" w="90" h="30"/>
        <glyph id="Node14" class="state variable">
          <state value="Ps"/>
          <bbox x="0" y="0" w="12" h="12"/>
        </glyph>
      </glyph>
      <glyph id="Node15" class="macromolecule" obj_id="4">
        <label text="MAPK8"/>
        <bbox x="443.14558369892313" y="45.55593840629271" w="90" h="30"/>
        <glyph id="Node16" class="state variable">
          <state value="Ps"/>
          <bbox x="0" y="0" w="12" h="12"/>
        </glyph>
      </glyph>
    </glyph>
    <glyph id="Node18" class="process">
      <bbox x="373.49725001807457" y="28.148787627790618" w="15" h="15"/>
      <port id="Node18.1" x="382.62225001807457" y="37.27378762779062"/>
      <port id="Node18.2" x="382.62225001807457" y="37.27378762779062"/>
    </glyph>
    <arc id="Node2-Node7" class="modulation" source="Node2" target="Node7">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node2-Node8" class="modulation" source="Node2" target="Node8">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node1-Node12.1" class="consumption" source="Node1" target="Node12.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node2-Node12.1" class="consumption" source="Node2" target="Node12.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node12.2-Node3" class="production" source="Node12.2" target="Node3">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node13-Node17" class="modulation" source="Node13" target="Node17">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node3-Node18.1" class="consumption" source="Node3" target="Node18.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node4-Node18" class="catalysis" source="Node4" target="Node18">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node18.2-Node5" class="production" source="Node18.2" target="Node5">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
  </map>
  <formatOutput>1</formatOutput>
</sbgn>
