1.0.0 Q13043-1 1 1 1 FALSE STK4(P) 1 Q13043 IID00168 a.k.a. MST1; activated form (phosphorylated at T183 in the activation loop); activated Hippo signaling pathway (Hippo ON);autophosphorylates its linker region at multiple sites to create a phosphor-docking site for MOB1 in STK4/STK4 homodimer or STK4/SAV1 heterotetramer FALSE Phosphorylation 1 183 183 2 1 1 FALSE STK4(Ps) 1 Q13043 IID00168 phosphorylated residues in the linker region for Mob1 binding can be: T353, T367 FALSE Phosphorylations 1 183 183 3 1 1 FALSE STK4(Ps) 1 Q13043 IID00168 FALSE Phosphorylations 1 183 183 2 353 353 3 367 367 2 1 FALSE MOB1A 1 Q9H8S9 IID00737 or MOB1B; autoinhibitory state FALSE 4 1 1 FALSE 5twg 5twh STK4(Ps) 1 Q13043 IID00168 FALSE 5twgE 5twhE Phosphorylations 1 183 183 2 353 353 3 367 367 MOB1A 1 Q9H8S9 IID00737 open conformation for LATS binding FALSE 5twgA 5twhA 5 1 1 FALSE STK4(Ps) 1 Q13043 IID00168 FALSE Phosphorylations 1 183 183 2 353 353 3 367 367 MOB1A 1 Q9H8S9 IID00737 FALSE 2 1 FALSE LATS 1 O95835 2 Q9NRM7 LATS1 or LATS2 FALSE 6 1 1 FALSE STK4(Ps) 1 Q13043 IID00168 FALSE Phosphorylations 1 183 183 2 353 353 3 367 367 MOB1A 1 Q9H8S9 IID00737 FALSE LATS 1 O95835 2 Q9NRM7 FALSE 7 1 1 FALSE STK4(Ps) 1 Q13043 IID00168 phosphorylates MOB1 at its N-terminal tail and LATS at its hydrophobic motif. FALSE Phosphorylations 1 183 183 2 353 353 3 367 367 8 1 1 FALSE STK4(Ps) 1 Q13043 IID00168 FALSE Phosphorylations 1 183 183 2 353 353 3 367 367 MOB1A(Ps) 1 Q9H8S9 IID00737 FALSE Phosphorylations 1 LATS(P) 1 O95835 2 Q9NRM7 FALSE Phosphorylation 1 9 1 1 FALSE STK4(Ps) 1 Q13043 IID00168 FALSE Phosphorylations 1 183 183 2 353 353 3 367 367 2 1 promotes downstream Hippo signaling FALSE MOB1A(Ps) 1 Q9H8S9 IID00737 FALSE Phosphorylations 1 LATS(P) 1 O95835 2 Q9NRM7 FALSE Phosphorylation 1 1 1 FALSE 1 2 28373298 26728553 26108669 30038061 2 3 FALSE 4 3 5 FALSE 6 4 6 TRUE 7 8 5 8 FALSE 9 1 1 result 2 1 2 operand 3 1 2 2 result 4 1 3 operand 5 1