<?xml version="1.0" encoding="utf-8"?>
<IDEAL>
  <Version>1.0.0</Version>
  <BiologicalPhenomenon>
    <IdealID/>
    <UniprotAccession>Q13043-1</UniprotAccession>
    <Object>
      <obj_id>1</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>STK4(P)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q13043</uniprot_accession>
              <ideal_id>IID00168</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>a.k.a. MST1; activated form (phosphorylated at T183 in the activation loop); activated Hippo signaling pathway (Hippo ON);autophosphorylates its linker region at multiple sites to create a phosphor-docking site for MOB1</phenotype>
            <complex>in STK4/STK4 homodimer or STK4/SAV1 heterotetramer</complex>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylation</type>
              <region>
                <region_id>1</region_id>
                <region_start>183</region_start>
                <region_end>183</region_end>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>2</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>STK4(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q13043</uniprot_accession>
              <ideal_id>IID00168</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>phosphorylated residues in the linker region for Mob1 binding can be: T353, T367</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>183</region_start>
                <region_end>183</region_end>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>3</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>STK4(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q13043</uniprot_accession>
              <ideal_id>IID00168</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>183</region_start>
                <region_end>183</region_end>
              </region>
              <region>
                <region_id>2</region_id>
                <region_start>353</region_start>
                <region_end>353</region_end>
              </region>
              <region>
                <region_id>3</region_id>
                <region_start>367</region_start>
                <region_end>367</region_end>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>MOB1A</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q9H8S9</uniprot_accession>
              <ideal_id>IID00737</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>or MOB1B; autoinhibitory state</phenotype>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>4</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <pdb>
            <pdb_id>5twg</pdb_id>
          </pdb>
          <pdb>
            <pdb_id>5twh</pdb_id>
          </pdb>
          <protein>
            <symbol>STK4(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q13043</uniprot_accession>
              <ideal_id>IID00168</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>5twgE</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>5twhE</pdb_id>
            </pdb>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>183</region_start>
                <region_end>183</region_end>
              </region>
              <region>
                <region_id>2</region_id>
                <region_start>353</region_start>
                <region_end>353</region_end>
              </region>
              <region>
                <region_id>3</region_id>
                <region_start>367</region_start>
                <region_end>367</region_end>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>MOB1A</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q9H8S9</uniprot_accession>
              <ideal_id>IID00737</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>open conformation for LATS binding</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>5twgA</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>5twhA</pdb_id>
            </pdb>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>5</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>STK4(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q13043</uniprot_accession>
              <ideal_id>IID00168</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>183</region_start>
                <region_end>183</region_end>
              </region>
              <region>
                <region_id>2</region_id>
                <region_start>353</region_start>
                <region_end>353</region_end>
              </region>
              <region>
                <region_id>3</region_id>
                <region_start>367</region_start>
                <region_end>367</region_end>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>MOB1A</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q9H8S9</uniprot_accession>
              <ideal_id>IID00737</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>LATS</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>O95835</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>2</uniprot_accessions_id>
              <uniprot_accession>Q9NRM7</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <location/>
            <phenotype>LATS1 or LATS2</phenotype>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>6</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>STK4(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q13043</uniprot_accession>
              <ideal_id>IID00168</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>183</region_start>
                <region_end>183</region_end>
              </region>
              <region>
                <region_id>2</region_id>
                <region_start>353</region_start>
                <region_end>353</region_end>
              </region>
              <region>
                <region_id>3</region_id>
                <region_start>367</region_start>
                <region_end>367</region_end>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>MOB1A</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q9H8S9</uniprot_accession>
              <ideal_id>IID00737</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
          <protein>
            <symbol>LATS</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>O95835</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>2</uniprot_accessions_id>
              <uniprot_accession>Q9NRM7</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>7</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>STK4(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q13043</uniprot_accession>
              <ideal_id>IID00168</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>phosphorylates MOB1 at its N-terminal tail and LATS at its hydrophobic motif.</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>183</region_start>
                <region_end>183</region_end>
              </region>
              <region>
                <region_id>2</region_id>
                <region_start>353</region_start>
                <region_end>353</region_end>
              </region>
              <region>
                <region_id>3</region_id>
                <region_start>367</region_start>
                <region_end>367</region_end>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>8</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>STK4(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q13043</uniprot_accession>
              <ideal_id>IID00168</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>183</region_start>
                <region_end>183</region_end>
              </region>
              <region>
                <region_id>2</region_id>
                <region_start>353</region_start>
                <region_end>353</region_end>
              </region>
              <region>
                <region_id>3</region_id>
                <region_start>367</region_start>
                <region_end>367</region_end>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>MOB1A(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q9H8S9</uniprot_accession>
              <ideal_id>IID00737</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start/>
                <region_end/>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>LATS(P)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>O95835</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>2</uniprot_accessions_id>
              <uniprot_accession>Q9NRM7</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylation</type>
              <region>
                <region_id>1</region_id>
                <region_start/>
                <region_end/>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>9</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>STK4(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q13043</uniprot_accession>
              <ideal_id>IID00168</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>183</region_start>
                <region_end>183</region_end>
              </region>
              <region>
                <region_id>2</region_id>
                <region_start>353</region_start>
                <region_end>353</region_end>
              </region>
              <region>
                <region_id>3</region_id>
                <region_start>367</region_start>
                <region_end>367</region_end>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype>promotes downstream Hippo signaling</phenotype>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>MOB1A(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q9H8S9</uniprot_accession>
              <ideal_id>IID00737</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start/>
                <region_end/>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>LATS(P)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>O95835</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>2</uniprot_accessions_id>
              <uniprot_accession>Q9NRM7</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylation</type>
              <region>
                <region_id>1</region_id>
                <region_start/>
                <region_end/>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Process>
      <process_id>1</process_id>
      <operand_obj_id>1</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id>1</operator_obj_id>
      <result_obj_id>2</result_obj_id>
      <pubmed>
        <pubmed_id>28373298</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>26728553</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>26108669</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>30038061</pubmed_id>
      </pubmed>
    </Process>
    <Process>
      <process_id>2</process_id>
      <operand_obj_id>3</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>4</result_obj_id>
    </Process>
    <Process>
      <process_id>3</process_id>
      <operand_obj_id>5</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>6</result_obj_id>
    </Process>
    <Process>
      <process_id>4</process_id>
      <operand_obj_id>6</operand_obj_id>
      <included_operand>TRUE</included_operand>
      <operator_obj_id>7</operator_obj_id>
      <result_obj_id>8</result_obj_id>
    </Process>
    <Process>
      <process_id>5</process_id>
      <operand_obj_id>8</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>9</result_obj_id>
    </Process>
    <IdenticalComponent>
      <identical_id>1</identical_id>
      <identicals>
        <process_id>1</process_id>
        <process_type>result</process_type>
        <obj_id>2</obj_id>
        <component_id>1</component_id>
      </identicals>
      <identicals>
        <process_id>2</process_id>
        <process_type>operand</process_type>
        <obj_id>3</obj_id>
        <component_id>1</component_id>
      </identicals>
    </IdenticalComponent>
    <IdenticalComponent>
      <identical_id>2</identical_id>
      <identicals>
        <process_id>2</process_id>
        <process_type>result</process_type>
        <obj_id>4</obj_id>
        <component_id>1</component_id>
      </identicals>
      <identicals>
        <process_id>3</process_id>
        <process_type>operand</process_type>
        <obj_id>5</obj_id>
        <component_id>1</component_id>
      </identicals>
    </IdenticalComponent>
  </BiologicalPhenomenon>
</IDEAL>

