1.0.0 Q13127-1 1 1 1 FALSE REST 1 Q13127 IID00169 represses neuronal gene transcription by binding RE1/NRSE sites FALSE 2 1 1 FALSE Ser/Thr_Kinase 1 P27361 2 P28482 e.g. ERK1/2, CK1 FALSE 3 1 1 FALSE REST(Ps) 1 Q13127 IID00169 C-terminal degrons (pS1024/1027/1030) are the target of SCF(BTRC) complex; S861/864 regulates REST stability, can be phosphorylated by ERK1/2 FALSE Phosphorylations 1 861 861 2 864 864 3 1024 1024 4 1027 1027 5 1030 1030 4 1 1 FALSE REST(Ps,Ub) 1 Q13127 IID00169 proteasomal degradation of REST, resulting in the derepression of proneural REST targets FALSE Phosphorylations 1 861 861 2 864 864 3 1024 1024 4 1027 1027 5 1030 1030 Ubiquitination 1 5 1 1 FALSE SCF(BTRC)_complex 1 Q9Y297 IID00254 2 P63208 3 Q13616 IID00133 4 P62877 IID00059 FALSE 6 1 1 FALSE REST(Ps) 1 Q13127 IID00169 FALSE Phosphorylations 1 861 861 2 864 864 3 1024 1024 4 1027 1027 5 1030 1030 2 1 FALSE CTDSP1 1 Q9GZU7 IID00394 FALSE 7 1 1 FALSE 6du3 REST(Ps) 1 Q13127 IID00169 FALSE 6du3C Phosphorylations 1 861 861 2 864 864 3 1024 1024 4 1027 1027 5 1030 1030 CTDSP1 1 Q9GZU7 IID00394 FALSE 6du3A 8 1 1 FALSE CTDSP1 1 Q9GZU7 IID00394 dephosphorylates pS861/864 of REST FALSE 9 1 1 FALSE REST(Ps) 1 Q13127 IID00169 FALSE Phosphorylations 1 1024 1024 2 1027 1027 3 1030 1030 CTDSP1 1 Q9GZU7 IID00394 FALSE 10 1 1 FALSE REST(Ps) 1 Q13127 IID00169 Dephosphorylation of pS861/864  stabilizies REST by preventing the binding of the SCF(BTRC) complex FALSE Phosphorylations 1 1024 1024 2 1027 1027 3 1030 1030 2 1 FALSE CTDSP1 1 Q9GZU7 IID00394 FALSE 1 1 FALSE 2 3 30217818 18354483 25197063 2 3 FALSE 5 4 3 6 FALSE 7 4 7 TRUE 8 9 5 9 FALSE 10 1 1 result 3 1 3 operand 6 1