1.0.0 Q13188-1 1 1 1 FALSE STK3(P) 1 Q13188 IID00721 a.k.a. MST2; activated Hippo signaling pathway (Hippo ON); activated form (phosphorylated at T180 in the activation loop); autophosphorylates its linker region at multiple sites to create a phosphor-docking site for MOB1 in STK3/STK3 homodimer or STK3/SAV1 heterotetramer FALSE Phosphorylation 1 180 180 2 1 1 FALSE STK3(Ps) 1 Q13188 IID00721 phosphorylated residues in the linker region for Mob1 binding can be: T349, T356, T364, and T378 FALSE Phosphorylations 1 180 180 2 378 378 3 1 1 FALSE STK3(Ps) 1 Q13188 IID00721 FALSE Phosphorylations 1 180 180 2 378 378 2 1 FALSE MOB1A 1 Q9H8S9 IID00737 or MOB1B; autoinhibitory state FALSE 4 1 1 FALSE 5brm STK3(Ps) 1 Q13188 IID00721 FALSE 5brmG Phosphorylations 1 180 180 2 378 378 MOB1A 1 Q9H8S9 IID00737 open conformation for LATS binding FALSE 5brmA 5 1 1 FALSE STK3(Ps) 1 Q13188 IID00721 FALSE Phosphorylations 1 177 177 2 378 378 MOB1A 1 Q9H8S9 IID00737 FALSE 2 1 FALSE LATS 1 O95835 2 Q9NRM7 LATS1 or LATS2 FALSE 6 1 1 FALSE STK3(Ps) 1 Q13188 IID00721 FALSE Phosphorylations 1 180 180 2 378 378 MOB1A 1 Q9H8S9 IID00737 FALSE LATS 1 O95835 2 Q9NRM7 FALSE 7 1 1 FALSE STK3(Ps) 1 Q13188 IID00721 FALSE Phosphorylations 1 180 180 2 378 378 MOB1A(Ps) 1 Q9H8S9 IID00737 FALSE Phosphorylations 1 12 12 2 35 35 LATS(P) 1 O95835 2 Q9NRM7 FALSE Phosphorylation 1 8 1 1 FALSE STK3(Ps) 1 Q13188 IID00721 FALSE Phosphorylations 1 180 180 2 378 378 2 1 promotes downstream Hippo signaling FALSE MOB1A(Ps) 1 Q9H8S9 IID00737 the phosphorylated N-terminal tail triggers the dissociation of MOB1/LATS1 from STK3 FALSE Phosphorylations 1 12 12 2 35 35 LATS(P) 1 O95835 2 Q9NRM7 FALSE Phosphorylation 1 9 1 1 FALSE STK3(Ps) 1 Q13188 IID00721 phosphorylates MOB1 at its N-terminal tail and LATS at its hydrophobic motif FALSE Phosphorylations 1 180 180 2 378 378 1 1 FALSE 1 2 26108669 26728553 30038061 2 3 FALSE 4 3 5 FALSE 6 4 6 TRUE 9 7 5 7 FALSE 8 1 1 result 2 1 2 operand 3 1 2 2 result 4 1 3 operand 5 1