<?xml version="1.0" encoding="utf-8"?>
<IDEAL>
  <Version>1.0.0</Version>
  <BiologicalPhenomenon>
    <IdealID/>
    <UniprotAccession>Q13188-2</UniprotAccession>
    <Object>
      <obj_id>1</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex>homodimer</complex>
          <llps>FALSE</llps>
          <protein>
            <symbol>STK3(P)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q13188</uniprot_accession>
              <ideal_id>IID00721</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>phosphorylated at T180 in the activation loop; autophosphorylates its linker region at multiple threonine-methionine (TM) motifs</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylation</type>
              <region>
                <region_id>1</region_id>
                <region_start>180</region_start>
                <region_end>180</region_end>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>2</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>STK3(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q13188</uniprot_accession>
              <ideal_id>IID00721</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>phosphorylated residues in the linker region for SLMAP binding can be: T325, T336, and T378</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>180</region_start>
                <region_end>180</region_end>
              </region>
              <region>
                <region_id>2</region_id>
                <region_start>378</region_start>
                <region_end>378</region_end>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>3</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>STK3(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q13188</uniprot_accession>
              <ideal_id>IID00721</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>180</region_start>
                <region_end>180</region_end>
              </region>
              <region>
                <region_id>2</region_id>
                <region_start>378</region_start>
                <region_end>378</region_end>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>SLMAP</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q14BN4</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <location/>
            <phenotype>adaptor component of STRIPAK complex</phenotype>
            <complex/>
            <llps>FALSE</llps>
          </protein>
          <protein>
            <symbol>STRIPAK_complex</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>4</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>STK3(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q13188</uniprot_accession>
              <ideal_id>IID00721</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>6ar2C</pdb_id>
            </pdb>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>180</region_start>
                <region_end>180</region_end>
              </region>
              <region>
                <region_id>2</region_id>
                <region_start>378</region_start>
                <region_end>378</region_end>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>SLMAP</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q14BN4</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <location/>
            <phenotype>binds to phospho-threonine of STK3 via its FHA domain</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>6ar2A</pdb_id>
            </pdb>
          </protein>
          <protein>
            <symbol>STRIPAK_complex</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>5</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>STRIPAK_complex</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>6</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>STK3(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q13188</uniprot_accession>
              <ideal_id>IID00721</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype> T180 dephosphorylated; inactivated; Hippo signaling pathway OFF </phenotype>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>378</region_start>
                <region_end>378</region_end>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>SLMAP</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q14BN4</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
          <protein>
            <symbol>STRIPAK_complex</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Process>
      <process_id>1</process_id>
      <operand_obj_id>1</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id>1</operator_obj_id>
      <result_obj_id>2</result_obj_id>
      <pubmed>
        <pubmed_id>29063833</pubmed_id>
      </pubmed>
    </Process>
    <Process>
      <process_id>2</process_id>
      <operand_obj_id>3</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>4</result_obj_id>
    </Process>
    <Process>
      <process_id>3</process_id>
      <operand_obj_id>4</operand_obj_id>
      <included_operand>TRUE</included_operand>
      <operator_obj_id>5</operator_obj_id>
      <result_obj_id>6</result_obj_id>
    </Process>
    <IdenticalComponent>
      <identical_id>1</identical_id>
      <identicals>
        <process_id>1</process_id>
        <process_type>result</process_type>
        <obj_id>2</obj_id>
        <component_id>1</component_id>
      </identicals>
      <identicals>
        <process_id>2</process_id>
        <process_type>operand</process_type>
        <obj_id>3</obj_id>
        <component_id>1</component_id>
      </identicals>
    </IdenticalComponent>
  </BiologicalPhenomenon>
</IDEAL>

