1.0.0 Q15910-1 1 1 1 FALSE EZH2 1 Q15910 IID00727 Autoinhibitory state (catalytically inactive) FALSE 4mi0A 4mi5A 2 1 FALSE EED 1 O75530 IID00530 FALSE 3 1 FALSE SUZ12 1 Q15022 IID00725 FALSE 4 1 FALSE RBBP4|7 1 Q09028 IID00317 2 Q16576 IID00084 FALSE 2 1 1 FALSE EZH2 1 Q15910 IID00727 Basal state (EZH2-EED-SUZ12 complex), release of autoinhibitory state, SRM is disordered FALSE EED 1 O75530 IID00530 FALSE SUZ12 1 Q15022 IID00725 FALSE RBBP4|7 1 Q09028 IID00317 2 Q16576 IID00084 FALSE 3 1 1 FALSE EZH2 1 Q15910 IID00727 FALSE EED 1 O75530 IID00530 FALSE SUZ12 1 Q15022 IID00725 FALSE RBBP4|7 1 Q09028 IID00317 2 Q16576 IID00084 FALSE 2 1 FALSE H3C1(me3) 1 P68431 IID00062 chromatin-associated; tri-methylated at Lys-28 (H3K27me3) FALSE me3 1 28 28 4 1 1 recruited to H3K27me3-marked chromatin FALSE EZH2 1 Q15910 IID00727 Stimulated state (EZH2-EED-SUZ12 complex + H3K27me3), SRM/SET-I interaction, catalytically active FALSE EED 1 O75530 IID00530 FALSE SUZ12 1 Q15022 IID00725 FALSE RBBP4|7 1 Q09028 IID00317 2 Q16576 IID00084 FALSE H3C1(me3) 1 P68431 IID00062 FALSE me3 1 28 28 5 1 1 FALSE EZH2 1 Q15910 IID00727 FALSE EED 1 O75530 IID00530 FALSE SUZ12 1 Q15022 IID00725 FALSE RBBP4|7 1 Q09028 IID00317 2 Q16576 IID00084 FALSE H3C1(me3) 1 P68431 IID00062 FALSE me3 1 28 28 2 1 FALSE H3C1 1 P68431 IID00062 chromatin-associated FALSE 6 1 1 PDB:5HYN contains EZH2, EED, SUZ12 (Vefs), the Jarid2 K116me3 peptide and the oncogenic H3K27M peptide, which binds to the EZH2-SET domain and inhibits its methyltransferase activity. FALSE EZH2 1 Q15910 IID00727 facilitates gene repression by propagating H3K27 methylation. FALSE 5hynA EED 1 O75530 IID00530 FALSE SUZ12 1 Q15022 IID00725 FALSE RBBP4|7 1 Q09028 IID00317 2 Q16576 IID00084 FALSE H3C1(me3) 1 P68431 IID00062 FALSE me3 1 28 28 H3C1 1 P68431 IID00062 FALSE 7 1 1 FALSE EZH2 1 Q15910 IID00727 FALSE EED 1 O75530 IID00530 FALSE SUZ12 1 Q15022 IID00725 FALSE RBBP4|7 1 Q09028 IID00317 2 Q16576 IID00084 FALSE H3C1(me3) 1 P68431 IID00062 FALSE me3 1 28 28 8 1 1 FALSE EZH2 1 Q15910 IID00727 FALSE EED 1 O75530 IID00530 FALSE SUZ12 1 Q15022 IID00725 FALSE RBBP4|7 1 Q09028 IID00317 2 Q16576 IID00084 FALSE H3C1(me3) 1 P68431 IID00062 FALSE me3 1 28 28 H3C1(Me) 1 P68431 IID00062 mono-, di-, or tri-methylated at Lys28 (H3K27me1|me2|me3) FALSE Methylation 1 28 28 1 1 FALSE 2 31123062 24367637 24367611 2 3 FALSE 4 3 5 FALSE 6 27121947 30951652 4 6 TRUE 7 8 1 1 result 2 1 2 operand 3 1 2 2 result 4 1 3 operand 5 1