1.0.0 Q16665-3 1 1 1 FALSE HIF1A 1 Q16665 IID00085 FALSE 2 1 FALSE KPNA2 1 P52292 IID00153 2 P52293 IID50009 FALSE 2 1 1 cytoplasm FALSE 8he0 HIF1A 1 Q16665 IID00085 FALSE 8he0B KPNA2 1 P52292 IID00153 2 P52293 IID50009 FALSE 8he0A 3 1 1 nucleus FALSE HIF1A 1 Q16665 IID00085 FALSE KPNA2 1 P52292 IID00153 2 P52293 IID50009 FALSE 4 1 1 FALSE HIF1A 1 Q16665 IID00085 FALSE 2 1 FALSE KPNA2 1 P52292 IID00153 2 P52293 IID50009 FALSE 5 1 1 FALSE HIF1A 1 Q16665 IID00085 FALSE 2 1 FALSE ARNT 1 P27540 a.k.a. HIF-1beta FALSE 6 1 1 HIF-1 complex FALSE HIF1A 1 Q16665 IID00085 FALSE ARNT 1 P27540 FALSE 7 1 1 FALSE HIF1A 1 Q16665 IID00085 FALSE ARNT 1 P27540 FALSE 2 1 FALSE EP300|CREBBP 1 Q09472 IID00070 2 P45481 IID50008 3 Q92793 IID00092 FALSE 3 1 FALSE HRE containing gene HRE:Hypoxia Response Element FALSE 8 1 1 activation of HIF-1 target genes, leading to cell proliferation, angiogenesis, metastasis, apoptosis resistance, survival and metabolic adaptation FALSE HIF1A 1 Q16665 IID00085 FALSE 1l3eA 1l8cB ARNT 1 P27540 FALSE EP300|CREBBP 1 Q09472 IID00070 2 P45481 IID50008 3 Q92793 IID00092 FALSE 1l3eB 1l8cA HRE containing gene FALSE 9 1 1 FALSE HIF1A 1 Q16665 IID00085 cytoplasm in normoxia FALSE 10 1 1 FALSE EGLN1|2|3 1 Q9GZT9 IID00345 2 Q96KS0 3 Q9H6Z9 a.k.a PHD1-3; cellular oxygen sensor; hydroxylates HIF-1alpha at P402 and P564 in normoxia FALSE 11 1 1 FALSE HIF1A(OH,OH) 1 Q16665 IID00085 FALSE OH 1 402 402 OH 1 564 564 12 1 1 FALSE HIF1A(OH,OH,Ub) 1 Q16665 IID00085 proteasomal degradation FALSE OH 1 402 402 OH 1 564 564 Ubiquitination 1 13 1 1 FALSE VHL 1 P40337 IID00371 in VCB complex composed of VHL, Elongin B, Elongin C, Cullin2, Rbx1 FALSE 14 1 1 FALSE HIF1A 1 Q16665 IID00085 in hypoxia FALSE 1 9 FALSE 10 11 12446723 19604478 12004076 33329393 30844107 2 11 FALSE 13 12 3 9 FALSE 14 4 1 FALSE 2 36806083 34067899 34575959 5 2 FALSE 3 6 3 FALSE 4 7 5 FALSE 6 8 7 FALSE 8 11959990 11959977 1 3 result 14 1 4 operand 1 1 2 6 result 4 1 7 operand 5 1 3 7 result 6 1 8 operand 7 1