<?xml version="1.0" encoding="utf-8"?>
<IDEAL>
  <Version>1.0.0</Version>
  <BiologicalPhenomenon>
    <IdealID/>
    <UniprotAccession>Q96RR4-1</UniprotAccession>
    <Object>
      <obj_id>1</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>CAMKK2</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q96RR4</uniprot_accession>
              <ideal_id>IID00866</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>2</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>AKT</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>3</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype>pS495</phenotype>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>CAMKK2(P)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q96RR4</uniprot_accession>
              <ideal_id>IID00866</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>directly impairs CaM binding and activation</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylation</type>
              <region>
                <region_id>1</region_id>
                <region_start>495</region_start>
                <region_end>495</region_end>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>4</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>AKT</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>5</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype>pS100, 511</phenotype>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>CAMKK2(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q96RR4</uniprot_accession>
              <ideal_id>IID00866</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>100</region_start>
                <region_end>100</region_end>
              </region>
              <region>
                <region_id>2</region_id>
                <region_start>511</region_start>
                <region_end>511</region_end>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>6</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>CAMKK2(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q96RR4</uniprot_accession>
              <ideal_id>IID00866</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>100</region_start>
                <region_end>100</region_end>
              </region>
              <region>
                <region_id>2</region_id>
                <region_start>511</region_start>
                <region_end>511</region_end>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>SFN|YWHAG|YWHAZ</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P31947</uniprot_accession>
              <ideal_id>IID00301</ideal_id>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>2</uniprot_accessions_id>
              <uniprot_accession>P61981</uniprot_accession>
              <ideal_id>IID00816</ideal_id>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>3</uniprot_accessions_id>
              <uniprot_accession>P63104</uniprot_accession>
              <ideal_id>IID00061</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>14-3-3  sigma|gamma|zeta/delta</phenotype>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>7</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>CAMKK2(Ps)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q96RR4</uniprot_accession>
              <ideal_id>IID00866</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>6ef5Q</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6ef5S</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6ef5P</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6ef5R</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6ewwE</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6ewwF</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6ewwG</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6ewwH</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6felE</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6felF</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6felG</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6felH</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6y3oP</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6y4kE</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6y4kF</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6y6bC</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6y6bD</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6y8aP</pdb_id>
            </pdb>
            <modification>
              <type>Phosphorylations</type>
              <region>
                <region_id>1</region_id>
                <region_start>100</region_start>
                <region_end>100</region_end>
              </region>
              <region>
                <region_id>2</region_id>
                <region_start>511</region_start>
                <region_end>511</region_end>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>SFN|YWHAG|YWHAZ</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P31947</uniprot_accession>
              <ideal_id>IID00301</ideal_id>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>2</uniprot_accessions_id>
              <uniprot_accession>P61981</uniprot_accession>
              <ideal_id>IID00816</ideal_id>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>3</uniprot_accessions_id>
              <uniprot_accession>P63104</uniprot_accession>
              <ideal_id>IID00061</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>keep CaMKK2 in the inactivated state</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>6ef5A</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6ef5B</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6ef5C</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6ef5D</pdb_id>
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            <pdb>
              <pdb_id>6ewwA</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6ewwB</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6ewwC</pdb_id>
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            <pdb>
              <pdb_id>6ewwD</pdb_id>
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            <pdb>
              <pdb_id>6felA</pdb_id>
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            <pdb>
              <pdb_id>6felB</pdb_id>
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            <pdb>
              <pdb_id>6felC</pdb_id>
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            <pdb>
              <pdb_id>6felD</pdb_id>
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            <pdb>
              <pdb_id>6y3oA</pdb_id>
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            <pdb>
              <pdb_id>6y4kA</pdb_id>
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            <pdb>
              <pdb_id>6y4kB</pdb_id>
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            <pdb>
              <pdb_id>6y6bA</pdb_id>
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            <pdb>
              <pdb_id>6y6bB</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6y8aA</pdb_id>
            </pdb>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Process>
      <process_id>1</process_id>
      <operand_obj_id>1</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id>2</operator_obj_id>
      <result_obj_id>3</result_obj_id>
      <pubmed>
        <pubmed_id>32913128</pubmed_id>
      </pubmed>
    </Process>
    <Process>
      <process_id>2</process_id>
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      <included_operand>FALSE</included_operand>
      <operator_obj_id>4</operator_obj_id>
      <result_obj_id>5</result_obj_id>
      <pubmed>
        <pubmed_id>32913128</pubmed_id>
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    </Process>
    <Process>
      <process_id>3</process_id>
      <operand_obj_id>6</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>7</result_obj_id>
      <pubmed>
        <pubmed_id>32913128</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>29639512</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>33006579</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>33146997</pubmed_id>
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    </Process>
    <IdenticalComponent>
      <identical_id>1</identical_id>
      <identicals>
        <process_id>2</process_id>
        <process_type>result</process_type>
        <obj_id>5</obj_id>
        <component_id>1</component_id>
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      <identicals>
        <process_id>3</process_id>
        <process_type>operand</process_type>
        <obj_id>6</obj_id>
        <component_id>1</component_id>
      </identicals>
    </IdenticalComponent>
  </BiologicalPhenomenon>
</IDEAL>

