1.0.0 Q96T88-1 1 1 1 FALSE UHRF1 1 Q96T88 IID00327 chromatin-occluded state (closed conformation) FALSE 5iayA 5iayB 6b9mA 6b9mB 6b9mD 2 1 FALSE USP7 1 Q93009 IID00176 FALSE 2 1 1 FALSE 5c6d UHRF1 1 Q96T88 IID00327 chromatin-accessible state (open conformation, can bind to H3K9me3) FALSE 5c6dC USP7 1 Q93009 IID00176 USP7 ubiquitin-like domains bind to the UHRF1 polybasic region; stabilizes UHRF1 via deubiquitination and protects it from autoubiquitination FALSE 5c6dA 3 1 1 FALSE UHRF1(P) 1 Q96T88 IID00327 M phase-specific phosphorylation at S639; undergoes ubiquitination-mediated protein degradation FALSE Phosphorylation 1 639 639 4 1 1 FALSE UHRF1 1 Q96T88 IID00327 FALSE 5 1 1 FALSE CCNB1|2|3 1 P14635 IID00141 2 O95067 3 Q8WWL7 FALSE CDK1 1 P06493 FALSE 1 1 FALSE 2 26299963 30666134 22411829 2 4 FALSE 5 3 1 1 operand 1 1 2 operand 4 1