1.0.0 Q96T88-2 1 1 1 FALSE UHRF1 1 Q96T88 IID00327 2 E7EZF3 chromatin-occluded state (closed conformation, a proline ring from UHRF1 PBR occupies the H3K9me3-binding cage of the TTD domain) FALSE 6b9mA 6b9mB 6b9mD 2 1 FALSE HmDNA-H3K9me3-NCP 1 P84243 IID00239 hemimethylated DNA (HmDNA) and H3K9me3-modified nucleosome (H3K9me3-NCP) FALSE 2 1 1 FALSE 3ask 4gy5 UHRF1 1 Q96T88 IID00327 2 E7EZF3 chromatin-accessible state (open conformation);TTD binds to H3K9me3; enhanced H3 ubiquitylation activity FALSE 3askA 4gy5A HmDNA-H3K9me3-NCP 1 P84243 IID00239 FALSE 3askP 4gy5E 3 1 1 FALSE UHRF1 1 Q96T88 IID00327 2 E7EZF3 FALSE 4 1 1 FALSE UHRF1 1 Q96T88 IID00327 2 E7EZF3 FALSE HmDNA-H3K9me3-NCP(mUb,mUb) 1 P84243 IID00239 dual mono-ubiquitylation of H3 on Lys-15, 19, 24(H3K14ub, H3K18ub, H3K23ub) recruits DNMT1 for DNA methylation maintenance FALSE mUb 1 mUb 1 5 1 1 FALSE UHRF1 1 Q96T88 IID00327 2 E7EZF3 FALSE HmDNA-H3K9me3-NCP(mUb,mUb) 1 P84243 IID00239 FALSE mUb 1 mUb 1 2 1 FALSE DNMT1 1 P26358 FALSE 6 1 1 FALSE UHRF1 1 Q96T88 IID00327 2 E7EZF3 FALSE HmDNA-H3K9me3-NCP(mUb,mUb) 1 P84243 IID00239 FALSE mUb 1 mUb 1 DNMT1 1 P26358 FALSE 1 1 FALSE 2 27045799 29395786 32144273 2 2 TRUE 3 4 3 5 FALSE 6 1 2 result 4 1 3 operand 5 1