<?xml version="1.0" encoding="utf-8"?>
<IDEAL>
  <Version>1.0.0</Version>
  <BiologicalPhenomenon>
    <IdealID/>
    <UniprotAccession>Q96T88-2</UniprotAccession>
    <Object>
      <obj_id>1</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>UHRF1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q96T88</uniprot_accession>
              <ideal_id>IID00327</ideal_id>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>2</uniprot_accessions_id>
              <uniprot_accession>E7EZF3</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <location/>
            <phenotype>chromatin-occluded state (closed conformation, a proline ring from UHRF1 PBR occupies the H3K9me3-binding cage of the TTD domain)</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>6b9mA</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6b9mB</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6b9mD</pdb_id>
            </pdb>
          </protein>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <nucleic_acid>
            <symbol>HmDNA-H3K9me3-NCP</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P84243</uniprot_accession>
              <ideal_id>IID00239</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>hemimethylated DNA (HmDNA) and H3K9me3-modified nucleosome (H3K9me3-NCP)</phenotype>
            <complex/>
            <llps>FALSE</llps>
          </nucleic_acid>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>2</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <pdb>
            <pdb_id>3ask</pdb_id>
          </pdb>
          <pdb>
            <pdb_id>4gy5</pdb_id>
          </pdb>
          <protein>
            <symbol>UHRF1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q96T88</uniprot_accession>
              <ideal_id>IID00327</ideal_id>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>2</uniprot_accessions_id>
              <uniprot_accession>E7EZF3</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <location/>
            <phenotype>chromatin-accessible state (open conformation);TTD binds to H3K9me3; enhanced H3 ubiquitylation activity</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>3askA</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>4gy5A</pdb_id>
            </pdb>
          </protein>
          <nucleic_acid>
            <symbol>HmDNA-H3K9me3-NCP</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P84243</uniprot_accession>
              <ideal_id>IID00239</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>3askP</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>4gy5E</pdb_id>
            </pdb>
          </nucleic_acid>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>3</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>UHRF1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q96T88</uniprot_accession>
              <ideal_id>IID00327</ideal_id>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>2</uniprot_accessions_id>
              <uniprot_accession>E7EZF3</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>4</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>UHRF1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q96T88</uniprot_accession>
              <ideal_id>IID00327</ideal_id>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>2</uniprot_accessions_id>
              <uniprot_accession>E7EZF3</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
          <nucleic_acid>
            <symbol>HmDNA-H3K9me3-NCP(mUb,mUb)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P84243</uniprot_accession>
              <ideal_id>IID00239</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>dual mono-ubiquitylation of H3 on Lys-15, 19, 24(H3K14ub, H3K18ub, H3K23ub) recruits DNMT1 for DNA methylation maintenance</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>mUb</type>
              <region>
                <region_id>1</region_id>
                <region_start/>
                <region_end/>
              </region>
            </modification>
            <modification>
              <type>mUb</type>
              <region>
                <region_id>1</region_id>
                <region_start/>
                <region_end/>
              </region>
            </modification>
          </nucleic_acid>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>5</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>UHRF1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q96T88</uniprot_accession>
              <ideal_id>IID00327</ideal_id>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>2</uniprot_accessions_id>
              <uniprot_accession>E7EZF3</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
          <nucleic_acid>
            <symbol>HmDNA-H3K9me3-NCP(mUb,mUb)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P84243</uniprot_accession>
              <ideal_id>IID00239</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>mUb</type>
              <region>
                <region_id>1</region_id>
                <region_start/>
                <region_end/>
              </region>
            </modification>
            <modification>
              <type>mUb</type>
              <region>
                <region_id>1</region_id>
                <region_start/>
                <region_end/>
              </region>
            </modification>
          </nucleic_acid>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>DNMT1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P26358</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>6</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>UHRF1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q96T88</uniprot_accession>
              <ideal_id>IID00327</ideal_id>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>2</uniprot_accessions_id>
              <uniprot_accession>E7EZF3</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
          <nucleic_acid>
            <symbol>HmDNA-H3K9me3-NCP(mUb,mUb)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P84243</uniprot_accession>
              <ideal_id>IID00239</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>mUb</type>
              <region>
                <region_id>1</region_id>
                <region_start/>
                <region_end/>
              </region>
            </modification>
            <modification>
              <type>mUb</type>
              <region>
                <region_id>1</region_id>
                <region_start/>
                <region_end/>
              </region>
            </modification>
          </nucleic_acid>
          <protein>
            <symbol>DNMT1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P26358</uniprot_accession>
              <ideal_id/>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Process>
      <process_id>1</process_id>
      <operand_obj_id>1</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>2</result_obj_id>
      <pubmed>
        <pubmed_id>27045799</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>29395786</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>32144273</pubmed_id>
      </pubmed>
    </Process>
    <Process>
      <process_id>2</process_id>
      <operand_obj_id>2</operand_obj_id>
      <included_operand>TRUE</included_operand>
      <operator_obj_id>3</operator_obj_id>
      <result_obj_id>4</result_obj_id>
    </Process>
    <Process>
      <process_id>3</process_id>
      <operand_obj_id>5</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>6</result_obj_id>
    </Process>
    <IdenticalComponent>
      <identical_id>1</identical_id>
      <identicals>
        <process_id>2</process_id>
        <process_type>result</process_type>
        <obj_id>4</obj_id>
        <component_id>1</component_id>
      </identicals>
      <identicals>
        <process_id>3</process_id>
        <process_type>operand</process_type>
        <obj_id>5</obj_id>
        <component_id>1</component_id>
      </identicals>
    </IdenticalComponent>
  </BiologicalPhenomenon>
</IDEAL>

