1.0.0 Q99814-2 1 1 1 FALSE EPAS1 1 Q99814 IID00629 a.k.a. HIF-2alpha FALSE 2 1 FALSE EGLN1 1 Q9GZT9 IID00345 a.k.a. PHD2 FALSE 2 1 1 FALSE 7q5v 7q5x 7ujv EPAS1 1 Q99814 IID00629 FALSE 7q5vB 7q5xB 7ujvA EGLN1 1 Q9GZT9 IID00345 FALSE 7q5vA 7q5xA 7ujvB 3 1 1 FALSE EGLN1 1 Q9GZT9 IID00345 FALSE 4 1 1 FALSE EPAS1(OH,OH) 1 Q99814 IID00629 hydroxylated on Pro-405 and Pro-531 in normoxia FALSE OH 1 405 405 OH 1 531 531 EGLN1 1 Q9GZT9 IID00345 FALSE 5 1 1 FALSE EPAS1(OH,OH) 1 Q99814 IID00629 The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. FALSE OH 1 405 405 OH 1 531 531 2 1 FALSE EGLN1 1 Q9GZT9 IID00345 FALSE 1 1 FALSE 2 37449559 38418569 2 2 TRUE 3 4 3 4 FALSE 5