<?xml version="1.0" encoding="utf-8"?>
<IDEAL>
  <Version>1.0.0</Version>
  <BiologicalPhenomenon>
    <IdealID/>
    <UniprotAccession>Q99814-2</UniprotAccession>
    <Object>
      <obj_id>1</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>EPAS1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q99814</uniprot_accession>
              <ideal_id>IID00629</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>a.k.a. HIF-2alpha</phenotype>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>EGLN1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q9GZT9</uniprot_accession>
              <ideal_id>IID00345</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>a.k.a. PHD2</phenotype>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>2</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <pdb>
            <pdb_id>7q5v</pdb_id>
          </pdb>
          <pdb>
            <pdb_id>7q5x</pdb_id>
          </pdb>
          <pdb>
            <pdb_id>7ujv</pdb_id>
          </pdb>
          <protein>
            <symbol>EPAS1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q99814</uniprot_accession>
              <ideal_id>IID00629</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>7q5vB</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>7q5xB</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>7ujvA</pdb_id>
            </pdb>
          </protein>
          <protein>
            <symbol>EGLN1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q9GZT9</uniprot_accession>
              <ideal_id>IID00345</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>7q5vA</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>7q5xA</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>7ujvB</pdb_id>
            </pdb>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>3</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>EGLN1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q9GZT9</uniprot_accession>
              <ideal_id>IID00345</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>4</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>EPAS1(OH,OH)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q99814</uniprot_accession>
              <ideal_id>IID00629</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>hydroxylated on Pro-405 and Pro-531 in normoxia</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>OH</type>
              <region>
                <region_id>1</region_id>
                <region_start>405</region_start>
                <region_end>405</region_end>
              </region>
            </modification>
            <modification>
              <type>OH</type>
              <region>
                <region_id>1</region_id>
                <region_start>531</region_start>
                <region_end>531</region_end>
              </region>
            </modification>
          </protein>
          <protein>
            <symbol>EGLN1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q9GZT9</uniprot_accession>
              <ideal_id>IID00345</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>5</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>EPAS1(OH,OH)</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q99814</uniprot_accession>
              <ideal_id>IID00629</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation.</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <modification>
              <type>OH</type>
              <region>
                <region_id>1</region_id>
                <region_start>405</region_start>
                <region_end>405</region_end>
              </region>
            </modification>
            <modification>
              <type>OH</type>
              <region>
                <region_id>1</region_id>
                <region_start>531</region_start>
                <region_end>531</region_end>
              </region>
            </modification>
          </protein>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>EGLN1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q9GZT9</uniprot_accession>
              <ideal_id>IID00345</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Process>
      <process_id>1</process_id>
      <operand_obj_id>1</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>2</result_obj_id>
      <pubmed>
        <pubmed_id>37449559</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>38418569</pubmed_id>
      </pubmed>
    </Process>
    <Process>
      <process_id>2</process_id>
      <operand_obj_id>2</operand_obj_id>
      <included_operand>TRUE</included_operand>
      <operator_obj_id>3</operator_obj_id>
      <result_obj_id>4</result_obj_id>
    </Process>
    <Process>
      <process_id>3</process_id>
      <operand_obj_id>4</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>5</result_obj_id>
    </Process>
  </BiologicalPhenomenon>
</IDEAL>

