1.0.0 Q99967-1 1 1 1 FALSE HIF1A/ARNT 1 Q16665 IID00085 2 P27540 Upon hypoxia, HIF-1 alpha becomes stabilized, accumulates in the nucleus, forms a heterodimer with HIF-1 beta (ARNT) and binds to target gene promoters. FALSE 2 1 FALSE HRE_containing_gene HRE: Hypoxia Response Element FALSE 3 1 FALSE EP300|CREBBP 1 Q09472 IID00070 2 Q92793 IID00092 3 P45481 IID50008 FALSE 2 1 1 activation of hypoxia-responsive genes, including the CITED2 gene FALSE HIF1A/ARNT 1 Q16665 IID00085 2 P27540 FALSE HRE_containing_gene FALSE EP300|CREBBP 1 Q09472 IID00070 2 Q92793 IID00092 3 P45481 IID50008 FALSE 3 1 1 FALSE HIF1A/ARNT 1 Q16665 IID00085 2 P27540 FALSE HRE_containing_gene FALSE EP300|CREBBP 1 Q09472 IID00070 2 Q92793 IID00092 3 P45481 IID50008 FALSE 2 1 FALSE CITED2 1 Q99967 IID00179 under the direct transcriptional control of HIF-1 and strongly induced in response to hypoxia; a negative feedback regulator of HIF-1 transcriptional activity by competing for p300/CBP FALSE 4 1 1 transient ternary complex formation of CITED2, HIF-1 alpha and p300/CBP, prior to the displacement of HIF-1 alpha by CITED2 from the surface of p300/CBP FALSE HIF1A/ARNT 1 Q16665 IID00085 2 P27540 FALSE 7lvsF 7qgsB HRE_containing_gene FALSE EP300|CREBBP 1 Q09472 IID00070 2 Q92793 IID00092 3 P45481 IID50008 FALSE 7lvsB 7qgsA CITED2 1 Q99967 IID00179 FALSE 7lvsF 7qgsB 5 1 1 reduced HIF-1 transcriptional activity FALSE HIF1A/ARNT 1 Q16665 IID00085 2 P27540 FALSE HRE_containing_gene FALSE 2 1 FALSE 1p4q 1r8u CITED2 1 Q99967 IID00179 FALSE 1p4qA 1r8uA EP300|CREBBP 1 Q09472 IID00070 2 Q92793 IID00092 3 P45481 IID50008 FALSE 1p4qB 1r8uB 1 1 FALSE 2 12778114 14594809 34520739 35656479 21925214 2 3 FALSE 4 3 4 FALSE 5 1 1 result 2 1 2 operand 3 1