1.0.0 Q9GZV5-1 1 1 1 FALSE WWTR1 1 Q9GZV5 cytoplasm FALSE 2 1 1 FALSE WWTR1(Ps) 1 Q9GZV5 phosphorylation sites by LAST1|2: S89, S311 FALSE Phosphorylations 1 3 1 1 activated by STK4|3 (MST1|2)-mediated phosphorylation FALSE LATS1|2 1 O95835 2 Q9NRM7 FALSE MOB1A|B 1 Q9H8S9 IID00737 2 Q7L9L4 FALSE 4 1 1 FALSE WWTR1(Ps) 1 Q9GZV5 FALSE Phosphorylations 1 2 1 FALSE SFN 1 P31947 IID00301 FALSE 5 1 1 FALSE 5n75 WWTR1(Ps) 1 Q9GZV5 S89 phosphorylation-dependent 14–3–3 binding; cytoplasmic retention FALSE 5n75P Phosphorylations 1 89 89 SFN 1 P31947 IID00301 FALSE 5n75A 6 1 1 FALSE CSNK1E 1 P49674 recognises pS311-WWTR1 and phosphorylates S314 FALSE 7 1 1 FALSE WWTR1(Ps) 1 Q9GZV5 degraded by SCF beta-TRCP-mediated ubiquitination FALSE Phosphorylations 1 311 311 2 314 314 9 1 1 FALSE WWTR1 1 Q9GZV5 nucleus forms complexes with TEAD transcription factors and activates Hippo-responsive genes that are involved in cell proliferation, migration, and survival FALSE 1 1 FALSE 3 2 28681606 20858893 18227151 30038061 2 4 FALSE 5 3 2 FALSE 6 7 4 1 FALSE 9 1 1 result 2 1 2 operand 4 1