<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<sbgn xmlns="http://sbgn.org/libsbgn/0.2">
  <map language="process description">
    <extension>
      <selfEntry uniprot="Q9NRM7" iid=""/>
      <renderInformation id="renderInformation" program-name="sbgnviz" program-version="6.0.2" background-color="#00000000">
        <listOfColorDefinitions>
          <colorDefinition id="color_transparence" value="#ffffffff"/>
          <colorDefinition id="color_stroke" value="#555555"/>
          <colorDefinition id="color_white" value="#ffffff"/>
          <colorDefinition id="color_red" value="#ff0000"/>
          <colorDefinition id="color_association" value="#707070ff"/>
          <colorDefinition id="color_dissociation" value="#ffffff"/>
          <colorDefinition id="color_location" value="#e7effaff"/>
          <colorDefinition id="color_phenotype" value="#e7effaff"/>
          <colorDefinition id="color_complex" value="#e7effaff"/>
        </listOfColorDefinitions>
        <listOfStyles>
          <style id="macromolecule" idList="0 Node1 Node2 Node3 Node7 Node8 Node4 Node5 Node11 Node13">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="prop_phenotype" idList="0 Node6 Node10 Node14">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_phenotype" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="edge" idList="0 Node2-Node6 Node1-Node9.1 Node2-Node9.1 Node9.2-Node3 Node4-Node10 Node11-Node14 Node3-Node15.1 Node4-Node15 Node15.2-Node5">
            <g stroke="color_stroke" stroke-width="1.25"/>
          </style>
          <style id="association" idList="0 Node9">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_association" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="state_variable" idList="0 Node12">
            <g stroke="color_stroke" stroke-width="1" fill="color_white" font-size="9" font-family="monospace" font-weight="normal" font-style="normal" font-color="#0f0f0f"/>
          </style>
          <style id="process" idList="0 Node15">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" background-image-opacity="1" background-opacity="1"/>
          </style>
        </listOfStyles>
      </renderInformation>
      <mapProperties>
        <compoundPadding>0</compoundPadding>
        <extraCompartmentPadding>14</extraCompartmentPadding>
        <extraComplexPadding>10</extraComplexPadding>
        <arrowScale>1.25</arrowScale>
        <showComplexName>true</showComplexName>
        <dynamicLabelSize>regular</dynamicLabelSize>
        <inferNestingOnLoad>false</inferNestingOnLoad>
        <fitLabelsToNodes>false</fitLabelsToNodes>
        <fitLabelsToInfoboxes>false</fitLabelsToInfoboxes>
        <recalculateLayoutOnComplexityManagement>true</recalculateLayoutOnComplexityManagement>
        <rearrangeOnComplexityManagement>true</rearrangeOnComplexityManagement>
        <animateOnDrawingChanges>true</animateOnDrawingChanges>
        <adjustNodeLabelFontSizeAutomatically>false</adjustNodeLabelFontSizeAutomatically>
        <enablePorts>true</enablePorts>
        <enableSIFTopologyGrouping>false</enableSIFTopologyGrouping>
        <allowCompoundNodeResize>true</allowCompoundNodeResize>
        <mapColorScheme>black_white</mapColorScheme>
        <mapColorSchemeStyle>solid</mapColorSchemeStyle>
        <mapName>Pathway #8</mapName>
        <highlightColor>#0B9BCD</highlightColor>
        <extraHighlightThickness>2</extraHighlightThickness>
      </mapProperties>
      <popperInfo>
        <glyph id="Node1">
          <entry uniprot="Q9NRM7"/>
        </glyph>
        <glyph id="Node2">
          <entry uniprot="P35240"/>
        </glyph>
        <glyph id="Node3">
          <pdb pdb_id="4zri"/>
        </glyph>
        <glyph id="Node7">
          <entry uniprot="Q9NRM7"/>
          <pdb pdb_id="4zriC"/>
        </glyph>
        <glyph id="Node8">
          <entry uniprot="P35240"/>
          <pdb pdb_id="4zriA"/>
        </glyph>
        <glyph id="Node4">
          <entry uniprot="Q13043" iid="IID00168"/>
          <entry uniprot="Q13188" iid="IID00721"/>
        </glyph>
        <glyph id="Node11">
          <entry uniprot="Q9NRM7"/>
        </glyph>
        <glyph id="Node13">
          <entry uniprot="P35240"/>
        </glyph>
        <arc id="Node1-Node9.1">
          <process process_no="1"/>
        </arc>
        <arc id="Node2-Node9.1">
          <process process_no="1"/>
        </arc>
        <arc id="Node9.2-Node3">
          <process process_no="1"/>
        </arc>
        <arc id="Node3-Node15.1">
          <process process_no="2"/>
        </arc>
        <arc id="Node4-Node15">
          <process process_no="2"/>
        </arc>
        <arc id="Node15.2-Node5">
          <process process_no="2"/>
        </arc>
      </popperInfo>
      <isEdited>true</isEdited>
    </extension>
    <glyph id="Node6" class="phenotype" obj_id="1">
      <label text="a.k.a. Merlin; recruits LATS&#xA;kinase to the cell membrane&#xA;through direct binding"/>
      <bbox x="-119.53074837549684" y="242.82614210609466" w="252" h="30"/>
    </glyph>
    <glyph id="Node10" class="phenotype" obj_id="3">
      <label text="a.k.a. MST1|2"/>
      <bbox x="272.3616525671998" y="20.179711926697692" w="120" h="30"/>
    </glyph>
    <glyph id="Node14" class="phenotype" obj_id="4">
      <label text="undergoes autophosphorylation&#xA;of its activation loop; promotes&#xA;downstream Hippo signaling"/>
      <bbox x="499.2242709498221" y="117.21629643645656" w="288" h="30"/>
    </glyph>
    <glyph id="Node1" class="macromolecule" obj_id="1">
      <label text="LATS2"/>
      <bbox x="-47.06311406232785" y="79.81222854861824" w="90" h="30"/>
    </glyph>
    <glyph id="Node2" class="macromolecule" obj_id="1">
      <label text="NF2"/>
      <bbox x="-41.00409814447745" y="188.6833306959583" w="90" h="30"/>
    </glyph>
    <glyph id="Node3" class="complex" obj_id="2">
      <bbox x="136.71647643659603" y="105.89108823251385" w="0" h="0"/>
      <glyph id="Node7" class="macromolecule" obj_id="2">
        <label text="LATS2"/>
        <bbox x="143.34147643659603" y="112.51608823251385" w="90" h="30"/>
      </glyph>
      <glyph id="Node8" class="macromolecule" obj_id="2">
        <label text="NF2"/>
        <bbox x="143.34147643659603" y="155.76608823251385" w="90" h="30"/>
      </glyph>
    </glyph>
    <glyph id="Node9" class="association">
      <bbox x="79.18109479182758" y="145.75718546937105" w="15" h="15"/>
      <port id="Node9.1" x="88.30609479182758" y="154.88218546937105"/>
      <port id="Node9.2" x="88.30609479182758" y="154.88218546937105"/>
    </glyph>
    <glyph id="Node4" class="macromolecule" obj_id="3">
      <label text="STK4|3"/>
      <bbox x="253.1250759465609" y="75.23985747048306" w="90" h="30"/>
    </glyph>
    <glyph id="Node5" class="complex" obj_id="4">
      <bbox x="365.17386509143773" y="95.63863198320246" w="0" h="0"/>
      <glyph id="Node11" class="macromolecule" obj_id="4">
        <label text="LATS2"/>
        <bbox x="373.4513239781242" y="102.26363198320246" w="90" h="30"/>
        <glyph id="Node12" class="state variable">
          <state value="P"/>
          <bbox x="0" y="0" w="12" h="12"/>
        </glyph>
      </glyph>
      <glyph id="Node13" class="macromolecule" obj_id="4">
        <label text="NF2"/>
        <bbox x="371.79886509143773" y="156.53903520421244" w="90" h="30"/>
      </glyph>
    </glyph>
    <glyph id="Node15" class="process">
      <bbox x="290.09008434282407" y="141.18325557549403" w="15" h="15"/>
      <port id="Node15.1" x="299.21508434282407" y="150.30825557549403"/>
      <port id="Node15.2" x="299.21508434282407" y="150.30825557549403"/>
    </glyph>
    <arc id="Node2-Node6" class="modulation" source="Node2" target="Node6">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node1-Node9.1" class="consumption" source="Node1" target="Node9.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node2-Node9.1" class="consumption" source="Node2" target="Node9.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node9.2-Node3" class="production" source="Node9.2" target="Node3">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node4-Node10" class="modulation" source="Node4" target="Node10">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node11-Node14" class="modulation" source="Node11" target="Node14">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node3-Node15.1" class="consumption" source="Node3" target="Node15.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node4-Node15" class="catalysis" source="Node4" target="Node15">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node15.2-Node5" class="production" source="Node15.2" target="Node5">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
  </map>
  <formatOutput>1</formatOutput>
</sbgn>
