<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<sbgn xmlns="http://sbgn.org/libsbgn/0.2">
  <map language="process description">
    <extension>
      <selfEntry uniprot="Q9UJM3" iid="IID00286"/>
      <renderInformation id="renderInformation" program-name="sbgnviz" program-version="6.0.2" background-color="#00000000">
        <listOfColorDefinitions>
          <colorDefinition id="color_transparence" value="#ffffffff"/>
          <colorDefinition id="color_stroke" value="#555555"/>
          <colorDefinition id="color_white" value="#ffffff"/>
          <colorDefinition id="color_red" value="#ff0000"/>
          <colorDefinition id="color_association" value="#707070ff"/>
          <colorDefinition id="color_dissociation" value="#ffffff"/>
          <colorDefinition id="color_location" value="#e7effaff"/>
          <colorDefinition id="color_phenotype" value="#e7effaff"/>
          <colorDefinition id="color_complex" value="#e7effaff"/>
        </listOfColorDefinitions>
        <listOfStyles>
          <style id="macromolecule" idList="0 Node1 Node2 Node3 Node4 Node12 Node13 Node5 Node6 Node16 Node17 Node18 Node7 Node21 Node22 Node23">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="prop_phenotype" idList="0 Node8 Node9 Node14 Node15 Node25 Node26">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_phenotype" font-size="11" font-family="monospace" font-weight="normal" font-style="normal" font-color="#000" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="edge" idList="0 Node1-Node8 Node2-Node9 Node1-Node11.1 Node2-Node11 Node11.2-Node3 Node4-Node14 Node12-Node15 Node4-Node20.1 Node3-Node20.1 Node20.2-Node5 Node21-Node25 Node23-Node26 Node5-Node27.1 Node6-Node27 Node27.2-Node7">
            <g stroke="color_stroke" stroke-width="1.25"/>
          </style>
          <style id="state_variable" idList="0 Node10 Node19 Node24">
            <g stroke="color_stroke" stroke-width="1" fill="color_white" font-size="9" font-family="monospace" font-weight="normal" font-style="normal" font-color="#0f0f0f"/>
          </style>
          <style id="process" idList="0 Node11 Node27">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_transparence" background-image-opacity="1" background-opacity="1"/>
          </style>
          <style id="association" idList="0 Node20">
            <g stroke="color_stroke" stroke-width="1.25" fill="color_association" background-image-opacity="1" background-opacity="1"/>
          </style>
        </listOfStyles>
      </renderInformation>
      <mapProperties>
        <compoundPadding>0</compoundPadding>
        <extraCompartmentPadding>14</extraCompartmentPadding>
        <extraComplexPadding>10</extraComplexPadding>
        <arrowScale>1.25</arrowScale>
        <showComplexName>true</showComplexName>
        <dynamicLabelSize>regular</dynamicLabelSize>
        <inferNestingOnLoad>false</inferNestingOnLoad>
        <fitLabelsToNodes>false</fitLabelsToNodes>
        <fitLabelsToInfoboxes>false</fitLabelsToInfoboxes>
        <recalculateLayoutOnComplexityManagement>true</recalculateLayoutOnComplexityManagement>
        <rearrangeOnComplexityManagement>true</rearrangeOnComplexityManagement>
        <animateOnDrawingChanges>true</animateOnDrawingChanges>
        <adjustNodeLabelFontSizeAutomatically>false</adjustNodeLabelFontSizeAutomatically>
        <enablePorts>true</enablePorts>
        <enableSIFTopologyGrouping>false</enableSIFTopologyGrouping>
        <allowCompoundNodeResize>true</allowCompoundNodeResize>
        <mapColorScheme>black_white</mapColorScheme>
        <mapColorSchemeStyle>solid</mapColorSchemeStyle>
        <mapName>Pathway #8</mapName>
        <highlightColor>#0B9BCD</highlightColor>
        <extraHighlightThickness>2</extraHighlightThickness>
      </mapProperties>
      <popperInfo>
        <glyph id="Node1">
          <entry uniprot="Q9UJM3" iid="IID00286"/>
        </glyph>
        <glyph id="Node2">
          <entry uniprot="P12931" iid="IID00708"/>
        </glyph>
        <glyph id="Node3">
          <entry uniprot="Q9UJM3" iid="IID00286"/>
        </glyph>
        <glyph id="Node12">
          <entry uniprot="P00533" iid="IID00262"/>
        </glyph>
        <glyph id="Node13">
          <entry uniprot="P01133" iid="IID00263"/>
        </glyph>
        <glyph id="Node16">
          <entry uniprot="P00533" iid="IID00262"/>
          <pdb pdb_id="4r3pA"/>
          <complex gene="ERRFI1" iid1="IID00262" iid2="IID00286" cluster="1491"/>
        </glyph>
        <glyph id="Node17">
          <entry uniprot="P01133" iid="IID00263"/>
        </glyph>
        <glyph id="Node18">
          <entry uniprot="Q9UJM3" iid="IID00286"/>
          <pdb pdb_id="4r3pB"/>
          <complex gene="EGFR" iid1="IID00286" iid2="IID00262" cluster="1491"/>
        </glyph>
        <glyph id="Node21">
          <entry uniprot="P00533" iid="IID00262"/>
          <pdb pdb_id="4zjvB"/>
          <pdb pdb_id="4r3rA"/>
          <complex gene="ERRFI1" iid1="IID00262" iid2="IID00286" cluster="1672"/>
          <complex gene="ERRFI1" iid1="IID00262" iid2="IID00286" cluster="1491"/>
        </glyph>
        <glyph id="Node22">
          <entry uniprot="P01133" iid="IID00263"/>
        </glyph>
        <glyph id="Node23">
          <entry uniprot="Q9UJM3" iid="IID00286"/>
          <pdb pdb_id="4zjvD"/>
          <pdb pdb_id="4r3rB"/>
          <complex gene="EGFR" iid1="IID00286" iid2="IID00262" cluster="1672"/>
          <complex gene="EGFR" iid1="IID00286" iid2="IID00262" cluster="1491"/>
        </glyph>
        <arc id="Node1-Node11.1">
          <process process_no="1"/>
        </arc>
        <arc id="Node2-Node11">
          <process process_no="1"/>
        </arc>
        <arc id="Node11.2-Node3">
          <process process_no="1"/>
        </arc>
        <arc id="Node4-Node20.1">
          <process process_no="2"/>
        </arc>
        <arc id="Node3-Node20.1">
          <process process_no="2"/>
        </arc>
        <arc id="Node20.2-Node5">
          <process process_no="2"/>
        </arc>
        <arc id="Node5-Node27.1">
          <process process_no="3"/>
        </arc>
        <arc id="Node6-Node27">
          <process process_no="3"/>
        </arc>
        <arc id="Node27.2-Node7">
          <process process_no="3"/>
        </arc>
      </popperInfo>
      <isEdited>true</isEdited>
    </extension>
    <glyph id="Node8" class="phenotype" obj_id="1">
      <label text="induced by EGF/EGFR&#xA;signaling pathway"/>
      <bbox x="39.08470301868786" y="177.1626090426647" w="171" h="30"/>
    </glyph>
    <glyph id="Node9" class="phenotype" obj_id="2">
      <label text="activated by EGF/EGFR&#xA;signaling pathway"/>
      <bbox x="118.4129737819253" y="11.910475363624592" w="189" h="30"/>
    </glyph>
    <glyph id="Node14" class="phenotype" obj_id="4">
      <label text="dimer"/>
      <bbox x="73.7600043838562" y="362.8937970229955" w="120" h="30"/>
    </glyph>
    <glyph id="Node15" class="phenotype" obj_id="4">
      <label text="ligand-induced extracellular dimerization; asymmetric dimerization of the&#xA;kinase domain; enzymatic activation of the receiver monomer and subsequent&#xA;autophosphorylation on the C-terminal tail of the activator monomer"/>
      <bbox x="182.13514206298692" y="342.86888730247665" w="666" h="30"/>
    </glyph>
    <glyph id="Node25" class="phenotype" obj_id="7">
      <label text="inactivated"/>
      <bbox x="857.5347281480213" y="189.88768118671388" w="120" h="30"/>
    </glyph>
    <glyph id="Node26" class="phenotype" obj_id="7">
      <label text="The segment 2 rearranges to block&#xA;the peptide-substrate binding cleft&#xA;of the active EGFR kinase domain"/>
      <bbox x="698.3524305667023" y="74.37409870099681" w="315" h="30"/>
    </glyph>
    <glyph id="Node1" class="macromolecule" obj_id="1">
      <label text="ERRFI1"/>
      <bbox x="77.46128356119985" y="119.5569819728332" w="90" h="30"/>
    </glyph>
    <glyph id="Node2" class="macromolecule" obj_id="2">
      <label text="SRC"/>
      <bbox x="169.83250869978065" y="70.89465821496435" w="90" h="30"/>
    </glyph>
    <glyph id="Node3" class="macromolecule" obj_id="3 4">
      <label text="ERRFI1"/>
      <bbox x="269.70103353657294" y="111.704402960718" w="90" h="30"/>
      <glyph id="Node10" class="state variable">
        <state value="P"/>
        <bbox x="0" y="0" w="12" h="12"/>
      </glyph>
    </glyph>
    <glyph id="Node11" class="process">
      <bbox x="208.446193199441" y="126.88914172201095" w="15" h="15"/>
      <port id="Node11.1" x="217.571193199441" y="136.01414172201095"/>
      <port id="Node11.2" x="217.571193199441" y="136.01414172201095"/>
    </glyph>
    <glyph id="Node4" class="complex" obj_id="4">
      <bbox x="178.60004319434574" y="242.57305371804267" w="0" h="0"/>
      <glyph id="Node12" class="macromolecule" obj_id="4">
        <label text="EGFR"/>
        <bbox x="186.95072255036004" y="292.44805371804256" w="90" h="30"/>
      </glyph>
      <glyph id="Node13" class="macromolecule" obj_id="4">
        <label text="EGF"/>
        <bbox x="185.22504319434577" y="249.19805371804267" w="90" h="30"/>
      </glyph>
    </glyph>
    <glyph id="Node5" class="complex" obj_id="5 6">
      <bbox x="495.50932352123743" y="121.35738238557394" w="0" h="0"/>
      <glyph id="Node6" class="complex" obj_id="5 6">
        <bbox x="502.13432352123743" y="190.17807979748432" w="0" h="0"/>
        <glyph id="Node16" class="macromolecule" obj_id="5 6">
          <label text="EGFR"/>
          <bbox x="508.75932352123743" y="196.8030797974843" w="90" h="30"/>
        </glyph>
        <glyph id="Node17" class="macromolecule" obj_id="5 6">
          <label text="EGF"/>
          <bbox x="508.75932352123743" y="240.0530797974842" w="90" h="30"/>
        </glyph>
      </glyph>
      <glyph id="Node18" class="macromolecule" obj_id="5">
        <label text="ERRFI1"/>
        <bbox x="506.8566060971808" y="127.98238238557394" w="90" h="30"/>
        <glyph id="Node19" class="state variable">
          <state value="P"/>
          <bbox x="0" y="0" w="12" h="12"/>
        </glyph>
      </glyph>
    </glyph>
    <glyph id="Node20" class="association">
      <bbox x="434.5816541141334" y="195.47120773712257" w="15" h="15"/>
      <port id="Node20.1" x="443.7066541141334" y="204.59620773712257"/>
      <port id="Node20.2" x="443.7066541141334" y="204.59620773712257"/>
    </glyph>
    <glyph id="Node7" class="complex" obj_id="7">
      <bbox x="724.2310158285547" y="121.75063371407214" w="0" h="0"/>
      <glyph id="Node21" class="macromolecule" obj_id="7">
        <label text="EGFR"/>
        <bbox x="732.5816951845688" y="191.28460151477995" w="90" h="30"/>
      </glyph>
      <glyph id="Node22" class="macromolecule" obj_id="7">
        <label text="EGF"/>
        <bbox x="730.8560158285546" y="233.16811641147774" w="90" h="30"/>
      </glyph>
      <glyph id="Node23" class="macromolecule" obj_id="7">
        <label text="ERRFI1"/>
        <bbox x="731.4312422805594" y="128.37563371407214" w="90" h="30"/>
        <glyph id="Node24" class="state variable">
          <state value="Ps"/>
          <bbox x="0" y="0" w="12" h="12"/>
        </glyph>
      </glyph>
    </glyph>
    <glyph id="Node27" class="process">
      <bbox x="662.5706843805855" y="193.61763838536282" w="15" h="15"/>
      <port id="Node27.1" x="671.6956843805855" y="202.74263838536282"/>
      <port id="Node27.2" x="671.6956843805855" y="202.74263838536282"/>
    </glyph>
    <arc id="Node1-Node8" class="modulation" source="Node1" target="Node8">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node2-Node9" class="modulation" source="Node2" target="Node9">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node1-Node11.1" class="consumption" source="Node1" target="Node11.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node2-Node11" class="catalysis" source="Node2" target="Node11">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node11.2-Node3" class="production" source="Node11.2" target="Node3">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node4-Node14" class="modulation" source="Node4" target="Node14">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node12-Node15" class="modulation" source="Node12" target="Node15">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node4-Node20.1" class="consumption" source="Node4" target="Node20.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node3-Node20.1" class="consumption" source="Node3" target="Node20.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node20.2-Node5" class="production" source="Node20.2" target="Node5">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node21-Node25" class="modulation" source="Node21" target="Node25">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node23-Node26" class="modulation" source="Node23" target="Node26">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node5-Node27.1" class="consumption" source="Node5" target="Node27.1">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node6-Node27" class="catalysis" source="Node6" target="Node27">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
    <arc id="Node27.2-Node7" class="production" source="Node27.2" target="Node7">
      <start x="0" y="0"/>
      <end x="0" y="0"/>
    </arc>
  </map>
  <formatOutput>1</formatOutput>
</sbgn>
