<?xml version="1.0" encoding="utf-8"?>
<IDEAL>
  <Version>1.0.0</Version>
  <BiologicalPhenomenon>
    <IdealID/>
    <UniprotAccession>Q9UJM3-2</UniprotAccession>
    <Object>
      <obj_id>1</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>EGFR</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P00533</uniprot_accession>
              <ideal_id>IID00262</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
          <protein>
            <symbol>EGF</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P01133</uniprot_accession>
              <ideal_id>IID00263</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>ERRFI1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q9UJM3</uniprot_accession>
              <ideal_id>IID00286</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>induced by EGF/EGFR signaling pathway</phenotype>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>2</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>EGFR</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P00533</uniprot_accession>
              <ideal_id>IID00262</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>inactivated; active conformation inhibited </phenotype>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>2rf9A</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>2rfdA</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>2rfeA</pdb_id>
            </pdb>
          </protein>
          <protein>
            <symbol>EGF</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>P01133</uniprot_accession>
              <ideal_id>IID00263</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
          <protein>
            <symbol>ERRFI1</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q9UJM3</uniprot_accession>
              <ideal_id>IID00286</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>The segment 1 binds to the C-lobe of the active EGFR kinase domain, blocking the asymmetric dimerization of the kinase domain</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>2rf9C</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>2rfdC</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>2rfeE</pdb_id>
            </pdb>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Process>
      <process_id>1</process_id>
      <operand_obj_id>1</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>2</result_obj_id>
      <pubmed>
        <pubmed_id>18046415</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>32172728</pubmed_id>
      </pubmed>
    </Process>
  </BiologicalPhenomenon>
</IDEAL>

