<?xml version="1.0" encoding="utf-8"?>
<IDEAL>
  <Version>1.0.0</Version>
  <BiologicalPhenomenon>
    <IdealID/>
    <UniprotAccession>Q9Y6Q9-1</UniprotAccession>
    <Object>
      <obj_id>1</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>CREBBP</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q92793</uniprot_accession>
              <ideal_id>IID00092</ideal_id>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>2</uniprot_accessions_id>
              <uniprot_accession>P45481</uniprot_accession>
              <ideal_id>IID50008</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>the nuclear coactivator binding domain of CBP is a molten globule</phenotype>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
      <component>
        <component_id>2</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>NCOA3</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q9Y6Q9</uniprot_accession>
              <ideal_id>IID00110</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
      <component>
        <component_id>3</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype/>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>NR-dimer</symbol>
            <location/>
            <phenotype>NR: nuclear receptor, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs); ligand-bound form</phenotype>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Object>
      <obj_id>2</obj_id>
      <component>
        <component_id>1</component_id>
        <sub_component>
          <sub_component_id>1</sub_component_id>
          <location/>
          <phenotype>transcriptional activation of target genes</phenotype>
          <complex/>
          <llps>FALSE</llps>
          <protein>
            <symbol>CREBBP</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q92793</uniprot_accession>
              <ideal_id>IID00092</ideal_id>
            </uniprot_accessions>
            <uniprot_accessions>
              <uniprot_accessions_id>2</uniprot_accessions_id>
              <uniprot_accession>P45481</uniprot_accession>
              <ideal_id>IID50008</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>1kbhB</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6es7B</pdb_id>
            </pdb>
          </protein>
          <protein>
            <symbol>NCOA3</symbol>
            <uniprot_accessions>
              <uniprot_accessions_id>1</uniprot_accessions_id>
              <uniprot_accession>Q9Y6Q9</uniprot_accession>
              <ideal_id>IID00110</ideal_id>
            </uniprot_accessions>
            <location/>
            <phenotype>binds NR using LXXLL motifs; plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin.</phenotype>
            <complex/>
            <llps>FALSE</llps>
            <pdb>
              <pdb_id>1kbhA</pdb_id>
            </pdb>
            <pdb>
              <pdb_id>6es7A</pdb_id>
            </pdb>
          </protein>
          <protein>
            <symbol>NR-dimer</symbol>
            <location/>
            <phenotype/>
            <complex/>
            <llps>FALSE</llps>
          </protein>
        </sub_component>
      </component>
    </Object>
    <Process>
      <process_id>1</process_id>
      <operand_obj_id>1</operand_obj_id>
      <included_operand>FALSE</included_operand>
      <operator_obj_id/>
      <result_obj_id>2</result_obj_id>
      <pubmed>
        <pubmed_id>11823864</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>30397651</pubmed_id>
      </pubmed>
      <pubmed>
        <pubmed_id>20616042</pubmed_id>
      </pubmed>
    </Process>
  </BiologicalPhenomenon>
</IDEAL>

