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IID00007  Axin-1 (Homo sapiens) O15169
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
862
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 74-220 Homo dimer :
 Evidence X-RAY 1dk8 A Reference
       Region 1dk8 A 74-220 order
Seq 80-211 Hetero dimer : IID00035Complex
 Evidence X-RAY 1emu A Reference
       Region 1emu A 80-211 order
Seq 375-394 Hetero dimer : IID00120Complex
 Evidence X-RAY 5wzz G Reference
       Region 5wzz G 375-377 disorder
       Region 5wzz G 378-387 order
       Region 5wzz G 388-394 disorder
 Evidence X-RAY 5wzz F Reference
       Region 5wzz F 375-378 disorder
       Region 5wzz F 379-387 order
       Region 5wzz F 388-394 disorder
 Evidence X-RAY 5wzz E Reference
       Region 5wzz E 375-376 disorder
       Region 5wzz E 377-387 order
       Region 5wzz E 388-394 disorder
 Evidence X-RAY 5wzz H Reference
       Region 5wzz H 375-376 disorder
       Region 5wzz H 377-387 order
       Region 5wzz H 388-394 disorder
Seq 383-400 Hetero tetramer : IID00052Complex
 Evidence X-RAY 1o9u B Reference
       Region 1o9u B 383-400 order
Seq 383-402 Hetero trimer : IID00052Complex
 Evidence X-RAY 4nm5 B Reference
       Region 4nm5 B 383-401 order
       Region 4nm5 B 402-402 disorder
Seq 383-402 Hetero dimer : IID00052Complex
 Evidence X-RAY 4b7t B Reference
       Region 4b7t B 383-400 order
 Evidence X-RAY 4nm0 B Reference
       Region 4nm0 B 383-401 order
       Region 4nm0 B 402-402 disorder
 Evidence X-RAY 4nm3 B Reference
       Region 4nm3 B 383-401 order
       Region 4nm3 B 402-402 disorder
 Evidence X-RAY 3zdi B Reference
       Region 3zdi B 383-383 disorder
       Region 3zdi B 384-400 order
Seq 383-402 Hetero trimer : IID00052Complex
 Evidence X-RAY 4nm7 B Reference
       Region 4nm7 B 383-401 order
       Region 4nm7 B 402-402 disorder
Seq 383-402 Hetero dimer : IID50236Complex
 Evidence X-RAY 4nu1 B Reference
       Region 4nu1 B 383-401 order
       Region 4nu1 B 402-402 disorder
SeqProS possible 383-400 This region binds to GSK3 beta. The binding site of this fragment in GSK3 beta is also the binding site for a fragment of FRAT. The axin fragment and the FRAT fragment share no sequence similarity. The binding sites to GSK3 beta are close, but the modes of binding are different. Hetero tetramer : IID00052Complex
       Region 1o9u B 383-400 order
SeqProS possible 383-401 This region binds to GSK3 beta. The binding site of this fragment in GSK3 beta is also the binding site for a fragment of FRAT. The axin fragment and the FRAT fragment share no sequence similarity. The binding sites to GSK3 beta are close, but the modes of binding are different. Hetero trimer : IID00052Complex
       Region 4nm5 B 383-401 order
SeqProS possible 383-401 This region binds to GSK3 beta. The binding site of this fragment in GSK3 beta is also the binding site for a fragment of FRAT. The axin fragment and the FRAT fragment share no sequence similarity. The binding sites to GSK3 beta are close, but the modes of binding are different. Hetero dimer : IID50236Complex
       Region 4nu1 B 383-401 order
SeqProS possible 383-401 This region binds to GSK3 beta. The binding site of this fragment in GSK3 beta is also the binding site for a fragment of FRAT. The axin fragment and the FRAT fragment share no sequence similarity. The binding sites to GSK3 beta are close, but the modes of binding are different. Hetero dimer : IID00052Complex
       Region 4nm3 B 383-401 order
       Region 4nm0 B 383-401 order
       Region 3zdi B 384-400 order
       Region 4b7t B 383-400 order
SeqProS possible 383-401 This region binds to GSK3 beta. The binding site of this fragment in GSK3 beta is also the binding site for a fragment of FRAT. The axin fragment and the FRAT fragment share no sequence similarity. The binding sites to GSK3 beta are close, but the modes of binding are different. Hetero trimer : IID00052Complex
       Region 4nm7 B 383-401 order
Seqphosphorylation
    75-75 Phosphoserine; by CK1
    77-77 Phosphoserine; by CK1
    217-217 Phosphoserine; by CK1
    469-469 Phosphoserine; by CK1
    481-481 Phosphothreonine; by GSK3-beta
    486-486 Phosphoserine
    493-493 Phosphoserine
    511-511 Phosphoserine
    581-581 Phosphoserine
 
Prediction
DICHOT
Disorder 1-17,221-364,403-779
Known Domain 18-220,780-862
Cryptic Domain 365-402
SCOPe RPS-Blast
     1dk8A 74-220 5e-57 a.91.1.1 Axin RGS-homologous domain
     1wspA1 780-862 2e-28 d.15.1.8 Axin 1
SCOP Hmmer
     1dk8A_ 76-218 1.3e-43 a.91.1.1 Axin RGS-homolog...
     1wspA1 781-862 4.6e-31 d.15.1.8 Axin 1
Pfam RPS-Blast
     PF16646 8-80 1e-20 Axin-1 tankyrase binding domai...
     PF00615 87-204 8e-08 Regulator of G protein signa...
     PF08833 464-521 8e-10 Axin beta-catenin binding d...
     PF00778 782-860 3e-18 DIX domain
Pfam Hmmer
    PF16646 10-80 9.8e-27 Axin-1 tankyrase binding dom...
    PF00615 88-210 3.2e-30 Regulator of G protein sign...
    PF08833 464-518 1.3e-12 Axin beta-catenin binding ...
    PF00778 782-859 4.4e-34 DIX domain