IDEAL List

IDEAL

IID00010
UniprotO60814
ProteinHistone H2B type 1-K
GeneH2BC12
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

126

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 1-126 Hetero octamer : IID00016Complex,IID00058Complex

Evidence X-RAY 2cv5 D Reference

Region 2cv5 D 1-30 disorder

Region 2cv5 D 31-126 order

Evidence X-RAY 2cv5 H Reference

Region 2cv5 H 1-31 disorder

Region 2cv5 H 32-125 order

Region 2cv5 H 126-126 disorder

Evidence X-RAY 6ke9 D Reference

Region 6ke9 D 32-126 order

Evidence X-RAY 6ke9 H Reference

Region 6ke9 H 32-125 order

Region 6ke9 H 126-126 disorder

Evidence X-RAY 6l9h D Reference

Region 6l9h D 32-126 order

Evidence X-RAY 6l9h H Reference

Region 6l9h H 32-125 order

Region 6l9h H 126-126 disorder

Evidence X-RAY 6le9 D Reference

Region 6le9 D 32-126 order

Evidence X-RAY 6le9 H Reference

Region 6le9 H 32-125 order

Region 6le9 H 126-126 disorder

Seqphosphorylation

15-15 Phosphoserine; by STK4/MST1

116-116 Phosphothreonine

37-37 Phosphoserine; by AMPK

Seqacetylation

17-17 N6-acetyllysine; alternate

21-21 N6-acetyllysine; alternate

24-24 N6-acetyllysine; alternate

2-2 N-acetylproline

6-6 N6-acetyllysine; alternate

12-12 N6-acetyllysine; alternate

13-13 N6-acetyllysine; alternate

16-16 N6-acetyllysine; alternate

86-86 N6-acetyllysine; alternate

Prediction

NeProc

Disorder 1-35,121-126

Order 36-120

ProS 121-126

AlphaFold

Disorder 1-1,24-24,26-34,126-126

Order 2-23,25-25,35-125

Pfam Hmmer

PF00125 32-102 9.2e-32

SEG 2-18 ,21-35

Function

Function in SwissProt

Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.